3G3K
Crystal structure of the GluR6 ligand binding domain dimer I442H K494E K665R I749L Q753K E757Q mutant with glutamate and NaCl at 1.24 Angstrom resolution
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE GLU A 260 |
| Chain | Residue |
| A | TYR61 |
| A | HOH273 |
| A | HOH275 |
| A | HOH287 |
| A | HOH312 |
| A | PRO89 |
| A | LEU90 |
| A | ALA91 |
| A | ARG96 |
| A | GLY141 |
| A | ALA142 |
| A | THR143 |
| A | GLU191 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 261 |
| Chain | Residue |
| A | LYS104 |
| A | ARG228 |
| B | LYS104 |
| B | ARG228 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 262 |
| Chain | Residue |
| A | GLY242 |
| A | LEU244 |
| A | HIS245 |
| B | HOH549 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 263 |
| Chain | Residue |
| A | TYR94 |
| A | ARG149 |
| A | IPA266 |
| A | HOH290 |
| B | LYS237 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 264 |
| Chain | Residue |
| A | GLU97 |
| A | ILE100 |
| A | ASP101 |
| A | MET223 |
| A | HOH421 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE IPA A 265 |
| Chain | Residue |
| A | PRO105 |
| A | THR108 |
| A | SER214 |
| A | LYS215 |
| A | HOH450 |
| B | THR108 |
| B | GLN239 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE IPA A 266 |
| Chain | Residue |
| A | TYR94 |
| A | VAL95 |
| A | GLU98 |
| A | CL263 |
| A | HOH290 |
| A | HOH321 |
| A | HOH583 |
| site_id | AC8 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE GLU B 260 |
| Chain | Residue |
| B | TYR61 |
| B | PRO89 |
| B | LEU90 |
| B | ALA91 |
| B | ARG96 |
| B | GLY141 |
| B | ALA142 |
| B | THR143 |
| B | GLU191 |
| B | HOH277 |
| B | HOH279 |
| B | HOH290 |
| B | HOH339 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 261 |
| Chain | Residue |
| B | SER5 |
| B | GLY118 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 262 |
| Chain | Residue |
| A | HOH334 |
| B | GLY242 |
| B | LEU244 |
| B | HIS245 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA B 263 |
| Chain | Residue |
| B | GLU97 |
| B | ILE100 |
| B | ASP101 |
| B | MET223 |
| B | HOH517 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15721240","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17115050","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1S50","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1S7Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2I0B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2I0C","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"15677325","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8163463","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
