3G2D

Complex of Mth0212 and a 4 bp dsDNA with 3'-overhang

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003824	molecular_function	catalytic activity
A	0003906	molecular_function	DNA-(apurinic or apyrimidinic site) endonuclease activity
A	0004518	molecular_function	nuclease activity
A	0004519	molecular_function	endonuclease activity
A	0006281	biological_process	DNA repair
A	0006284	biological_process	base-excision repair
A	0008081	molecular_function	phosphoric diester hydrolase activity
A	0008311	molecular_function	double-stranded DNA 3'-5' DNA exonuclease activity
A	0016787	molecular_function	hydrolase activity
A	0016829	molecular_function	lyase activity
A	0046872	molecular_function	metal ion binding
A	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B	0003677	molecular_function	DNA binding
B	0003824	molecular_function	catalytic activity
B	0003906	molecular_function	DNA-(apurinic or apyrimidinic site) endonuclease activity
B	0004518	molecular_function	nuclease activity
B	0004519	molecular_function	endonuclease activity
B	0006281	biological_process	DNA repair
B	0006284	biological_process	base-excision repair
B	0008081	molecular_function	phosphoric diester hydrolase activity
B	0008311	molecular_function	double-stranded DNA 3'-5' DNA exonuclease activity
B	0016787	molecular_function	hydrolase activity
B	0016829	molecular_function	lyase activity
B	0046872	molecular_function	metal ion binding
B	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 A 266

Chain	Residue
A	ARG209
A	THR210
A	HOH315
A	HOH407
K	DC1

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 A 267

Chain	Residue
A	HOH325
A	GLU228
A	GLU229
A	LYS231
A	GLY232

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 A 268

Chain	Residue
A	LYS116
A	ASN169
A	VAL170
A	SER171
A	HOH390
B	ASN169

---

site_id	AC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PG4 A 269

Chain	Residue
A	ASN12
A	ASN114
A	GLY115
A	LYS116
A	LYS125
A	ASN153
A	SER171
A	GLY172
A	GLU177
A	TRP205
A	LEU221
A	ASP247
A	HOH277
G	DG7

---

site_id	AC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PG4 A 270

Chain	Residue
A	TRP206
A	SER207
A	TYR208
A	ARG211
A	ARG213
A	MET244
A	SER246
A	ASP247
A	GOL274
K	DC1
K	DC2

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 271

Chain	Residue
A	HIS156
A	ARG157
A	ILE185
A	ASP191
A	HOH355

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PG4 A 272

Chain	Residue
A	ARG51
A	HIS52
A	VAL53
A	TYR56

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 273

Chain	Residue
A	GLU89
A	ARG90
A	THR93

---

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 274

Chain	Residue
A	LYS20
A	TYR208
A	MET244
A	GLY245
A	SER246
A	PG4270
A	HOH312

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 275

Chain	Residue
A	ARG213
A	SER241
A	ASP242
A	HOH297

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PG4 B 266

Chain	Residue
B	LYS183
B	GLU186
B	ASN187
B	HOH281

---

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL B 267

Chain	Residue
B	ARG48
B	ARG51

---

site_id	BC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GOL K 11

Chain	Residue
K	HOH83

---

Functional Information from PROSITE/UniProt

site_id	PS00726
Number of Residues	10
Details	AP_NUCLEASE_F1_1 AP endonucleases family 1 signature 1. PDILCLQEIK

Chain	Residue	Details
A	PRO31-LYS40

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton donor/acceptor => ECO:0000305|PubMed:20434457

Chain	Residue	Details
A	ASN151
B	ASN151

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:20434457, ECO:0000269|Ref.7

Chain	Residue	Details
A	ASN12
A	GLU38
B	ASN12
B	GLU38

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:20434457

Chain	Residue	Details
A	ASN151
A	ASN153
A	HIS248
B	ASN151
B	ASN153
B	HIS248

---