3FZZ
Structure of GrC
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001778 | biological_process | plasma membrane repair |
| A | 0002839 | biological_process | positive regulation of immune response to tumor cell |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0017148 | biological_process | negative regulation of translation |
| A | 0031640 | biological_process | killing of cells of another organism |
| A | 0042267 | biological_process | natural killer cell mediated cytotoxicity |
| A | 0044194 | cellular_component | cytolytic granule |
| A | 0046513 | biological_process | ceramide biosynthetic process |
| A | 0051603 | biological_process | proteolysis involved in protein catabolic process |
| A | 0051604 | biological_process | protein maturation |
| A | 0070269 | biological_process | pyroptotic inflammatory response |
| A | 0140507 | biological_process | granzyme-mediated programmed cell death signaling pathway |
| A | 0141201 | biological_process | pyroptotic cell death |
| B | 0001778 | biological_process | plasma membrane repair |
| B | 0002839 | biological_process | positive regulation of immune response to tumor cell |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006508 | biological_process | proteolysis |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0008236 | molecular_function | serine-type peptidase activity |
| B | 0016020 | cellular_component | membrane |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0017148 | biological_process | negative regulation of translation |
| B | 0031640 | biological_process | killing of cells of another organism |
| B | 0042267 | biological_process | natural killer cell mediated cytotoxicity |
| B | 0044194 | cellular_component | cytolytic granule |
| B | 0046513 | biological_process | ceramide biosynthetic process |
| B | 0051603 | biological_process | proteolysis involved in protein catabolic process |
| B | 0051604 | biological_process | protein maturation |
| B | 0070269 | biological_process | pyroptotic inflammatory response |
| B | 0140507 | biological_process | granzyme-mediated programmed cell death signaling pathway |
| B | 0141201 | biological_process | pyroptotic cell death |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2 |
| Chain | Residue |
| A | THR122 |
| A | ARG123 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 4 |
| Chain | Residue |
| A | PRO158 |
| A | LYS159 |
| A | THR160 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 6 |
| Chain | Residue |
| A | ARG132 |
| A | ARG133 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1 |
| Chain | Residue |
| B | ARG132 |
| B | ARG212 |
| A | ARG132 |
| A | ARG212 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 3 |
| Chain | Residue |
| B | THR122 |
| B | ARG123 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 5 |
| Chain | Residue |
| B | PRO158 |
| B | LYS159 |
| B | THR160 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 7 |
| Chain | Residue |
| B | ARG132 |
| B | ARG133 |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC |
| Chain | Residue | Details |
| A | LEU61-CYS66 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 450 |
| Details | Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | SER204 | |
| A | ASP109 | |
| A | HIS65 |
| site_id | CSA10 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | SER204 | |
| B | GLY205 |
| site_id | CSA11 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | SER204 | |
| A | ASP100 | |
| A | GLY197 | |
| A | HIS65 | |
| A | SER219 |
| site_id | CSA12 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | SER204 | |
| B | ASP100 | |
| B | GLY197 | |
| B | HIS65 | |
| B | SER219 |
| site_id | CSA13 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | SER204 | |
| A | ASP100 | |
| A | GLY197 | |
| A | HIS65 |
| site_id | CSA14 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | SER204 | |
| B | ASP100 | |
| B | GLY197 | |
| B | HIS65 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | SER204 | |
| B | ASP109 | |
| B | HIS65 |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | SER204 | |
| A | ASP109 | |
| A | HIS65 | |
| A | GLY205 |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | SER204 | |
| B | ASP109 | |
| B | HIS65 | |
| B | GLY205 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ASP109 | |
| A | HIS65 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | ASP109 | |
| B | HIS65 |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | SER204 | |
| A | GLU202 |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | SER204 | |
| B | GLU202 |
| site_id | CSA9 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | SER204 | |
| A | GLY205 |
