3FZY
Crystal Structure of Pre-cleavage Form of Cysteine Protease Domain from Vibrio cholerae RtxA Toxin
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE IHP A8000 |
| Chain | Residue |
| A | HOH8 |
| A | HOH195 |
| A | HOH254 |
| A | HOH257 |
| A | HOH259 |
| A | HOH312 |
| A | GLU3455 |
| A | THR3456 |
| A | ARG3457 |
| A | LYS3482 |
| A | HIS3483 |
| A | HOH21 |
| A | ARG3513 |
| A | SER3564 |
| A | SER3597 |
| A | ARG3599 |
| A | ARG3610 |
| A | LYS3611 |
| A | LYS3623 |
| A | LYS3628 |
| A | HOH29 |
| A | HOH41 |
| A | HOH49 |
| A | HOH65 |
| A | HOH97 |
| A | HOH151 |
| A | HOH166 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 1 |
| Chain | Residue |
| A | ARG3457 |
| B | GLU3525 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE UNX A 323 |
| Chain | Residue |
| A | UNX324 |
| A | UNX325 |
| A | UNX327 |
| A | UNX329 |
| A | UNX330 |
| A | UNX331 |
| A | SER3632 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE UNX A 324 |
| Chain | Residue |
| A | UNX323 |
| A | UNX325 |
| A | UNX327 |
| A | UNX329 |
| A | UNX331 |
| A | ASN3585 |
| A | TRP3633 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE UNX A 325 |
| Chain | Residue |
| A | UNX323 |
| A | UNX324 |
| A | UNX327 |
| A | UNX328 |
| A | UNX330 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX A 326 |
| Chain | Residue |
| A | UNX328 |
| A | HIS3581 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE UNX A 327 |
| Chain | Residue |
| A | UNX323 |
| A | UNX324 |
| A | UNX325 |
| A | UNX328 |
| A | ILE3584 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE UNX A 328 |
| Chain | Residue |
| A | UNX325 |
| A | UNX326 |
| A | UNX327 |
| A | HIS3581 |
| A | ASN3585 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE UNX A 329 |
| Chain | Residue |
| A | UNX323 |
| A | UNX324 |
| A | UNX330 |
| A | UNX331 |
| A | UNX333 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE UNX A 330 |
| Chain | Residue |
| A | UNX323 |
| A | UNX325 |
| A | UNX329 |
| A | UNX331 |
| A | UNX332 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE UNX A 331 |
| Chain | Residue |
| A | UNX323 |
| A | UNX324 |
| A | UNX329 |
| A | UNX330 |
| A | UNX332 |
| A | UNX333 |
| A | SER3632 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE UNX A 332 |
| Chain | Residue |
| A | UNX330 |
| A | UNX331 |
| A | SER3632 |
| A | ASP3634 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE UNX A 333 |
| Chain | Residue |
| A | UNX329 |
| A | UNX331 |
| A | UNX334 |
| site_id | BC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE UNX A 334 |
| Chain | Residue |
| A | UNX333 |
| site_id | BC6 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE IHP B8001 |
| Chain | Residue |
| B | ARG3610 |
| B | LYS3611 |
| B | LYS3623 |
| B | LYS3628 |
| B | HOH50 |
| B | HOH57 |
| B | HOH95 |
| B | HOH156 |
| B | HOH212 |
| B | GLU3455 |
| B | THR3456 |
| B | ARG3457 |
| B | LYS3482 |
| B | HIS3483 |
| B | ARG3513 |
| B | SER3564 |
| B | SER3597 |
| B | ARG3599 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 368 |
| Details | Domain: {"description":"Peptidase C80","evidences":[{"source":"PROSITE-ProRule","id":"PRU01107","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For cysteine protease activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01107","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17698571","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile; for cysteine protease activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01107","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17698571","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18845756","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19465933","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19620709","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3EEB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FZY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GCD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Site: {"description":"Cleavage; by autolysis","evidences":[{"source":"PubMed","id":"17464284","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18591243","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19465933","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19620709","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
