3FY7

Crystal structure of homo sapiens CLIC3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005254	molecular_function	chloride channel activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006821	biological_process	chloride transport
A	0007165	biological_process	signal transduction
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0016604	cellular_component	nuclear body
A	0019153	molecular_function	protein-disulfide reductase (glutathione) activity
A	0031012	cellular_component	extracellular matrix
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034702	cellular_component	monoatomic ion channel complex
A	0034707	cellular_component	chloride channel complex
A	0070062	cellular_component	extracellular exosome
A	1902476	biological_process	chloride transmembrane transport
A	1903672	biological_process	positive regulation of sprouting angiogenesis
B	0005254	molecular_function	chloride channel activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006821	biological_process	chloride transport
B	0007165	biological_process	signal transduction
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0016604	cellular_component	nuclear body
B	0019153	molecular_function	protein-disulfide reductase (glutathione) activity
B	0031012	cellular_component	extracellular matrix
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0034702	cellular_component	monoatomic ion channel complex
B	0034707	cellular_component	chloride channel complex
B	0070062	cellular_component	extracellular exosome
B	1902476	biological_process	chloride transmembrane transport
B	1903672	biological_process	positive regulation of sprouting angiogenesis

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A1000

Chain	Residue
A	ARG27
A	LEU76
A	HOH246
A	HOH365
B	LYS111
B	GLN130

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A1003

Chain	Residue
A	TYR128
A	ARG191
A	PHE115
A	ASP124
A	GLU125

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B1001

Chain	Residue
A	HIS221
A	SER222
A	HOH303
B	ALA197

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B1002

Chain	Residue
A	HIS110
A	LYS111
B	PHE109
B	HIS110
B	LYS179
B	HOH255
B	HOH353

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Motif: {"description":"G-site","evidences":[{"source":"PubMed","id":"28198360","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"37759794","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1oe8

Chain	Residue	Details
A	VAL10

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1oe8

Chain	Residue	Details
B	VAL10

---