3FWC

Sac3:Sus1:Cdc31 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000226	biological_process	microtubule cytoskeleton organization
A	0003674	molecular_function	molecular_function
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005635	cellular_component	nuclear envelope
A	0005816	cellular_component	spindle pole body
A	0005825	cellular_component	half bridge of spindle pole body
A	0006406	biological_process	mRNA export from nucleus
A	0008017	molecular_function	microtubule binding
A	0030474	biological_process	spindle pole body duplication
A	0042802	molecular_function	identical protein binding
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0044732	cellular_component	mitotic spindle pole body
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046872	molecular_function	metal ion binding
A	0048193	biological_process	Golgi vesicle transport
A	0051301	biological_process	cell division
A	0070390	cellular_component	transcription export complex 2
C	0000124	cellular_component	SAGA complex
C	0000932	cellular_component	P-body
C	0000973	biological_process	post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery
C	0003682	molecular_function	chromatin binding
C	0003713	molecular_function	transcription coactivator activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005643	cellular_component	nuclear pore
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0006325	biological_process	chromatin organization
C	0006351	biological_process	DNA-templated transcription
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0006368	biological_process	transcription elongation by RNA polymerase II
C	0006406	biological_process	mRNA export from nucleus
C	0008047	molecular_function	enzyme activator activity
C	0015031	biological_process	protein transport
C	0016973	biological_process	poly(A)+ mRNA export from nucleus
C	0032880	biological_process	regulation of protein localization
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0051028	biological_process	mRNA transport
C	0070390	cellular_component	transcription export complex 2
C	0071028	biological_process	nuclear mRNA surveillance
C	0071819	cellular_component	DUBm complex
D	0000124	cellular_component	SAGA complex
D	0000932	cellular_component	P-body
D	0000973	biological_process	post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery
D	0003682	molecular_function	chromatin binding
D	0003713	molecular_function	transcription coactivator activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005643	cellular_component	nuclear pore
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0006325	biological_process	chromatin organization
D	0006351	biological_process	DNA-templated transcription
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0006368	biological_process	transcription elongation by RNA polymerase II
D	0006406	biological_process	mRNA export from nucleus
D	0008047	molecular_function	enzyme activator activity
D	0015031	biological_process	protein transport
D	0016973	biological_process	poly(A)+ mRNA export from nucleus
D	0032880	biological_process	regulation of protein localization
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0051028	biological_process	mRNA transport
D	0070390	cellular_component	transcription export complex 2
D	0071028	biological_process	nuclear mRNA surveillance
D	0071819	cellular_component	DUBm complex
E	0000226	biological_process	microtubule cytoskeleton organization
E	0003674	molecular_function	molecular_function
E	0005509	molecular_function	calcium ion binding
E	0005515	molecular_function	protein binding
E	0005635	cellular_component	nuclear envelope
E	0005816	cellular_component	spindle pole body
E	0005825	cellular_component	half bridge of spindle pole body
E	0006406	biological_process	mRNA export from nucleus
E	0008017	molecular_function	microtubule binding
E	0030474	biological_process	spindle pole body duplication
E	0042802	molecular_function	identical protein binding
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0044732	cellular_component	mitotic spindle pole body
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0046872	molecular_function	metal ion binding
E	0048193	biological_process	Golgi vesicle transport
E	0051301	biological_process	cell division
E	0070390	cellular_component	transcription export complex 2
G	0000124	cellular_component	SAGA complex
G	0000932	cellular_component	P-body
G	0000973	biological_process	post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery
G	0003682	molecular_function	chromatin binding
G	0003713	molecular_function	transcription coactivator activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005643	cellular_component	nuclear pore
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0006325	biological_process	chromatin organization
G	0006351	biological_process	DNA-templated transcription
G	0006357	biological_process	regulation of transcription by RNA polymerase II
G	0006368	biological_process	transcription elongation by RNA polymerase II
G	0006406	biological_process	mRNA export from nucleus
G	0008047	molecular_function	enzyme activator activity
G	0015031	biological_process	protein transport
G	0016973	biological_process	poly(A)+ mRNA export from nucleus
G	0032880	biological_process	regulation of protein localization
G	0045893	biological_process	positive regulation of DNA-templated transcription
G	0045944	biological_process	positive regulation of transcription by RNA polymerase II
G	0051028	biological_process	mRNA transport
G	0070390	cellular_component	transcription export complex 2
G	0071028	biological_process	nuclear mRNA surveillance
G	0071819	cellular_component	DUBm complex
H	0000124	cellular_component	SAGA complex
H	0000932	cellular_component	P-body
H	0000973	biological_process	post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery
H	0003682	molecular_function	chromatin binding
H	0003713	molecular_function	transcription coactivator activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005643	cellular_component	nuclear pore
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0006325	biological_process	chromatin organization
H	0006351	biological_process	DNA-templated transcription
H	0006357	biological_process	regulation of transcription by RNA polymerase II
H	0006368	biological_process	transcription elongation by RNA polymerase II
H	0006406	biological_process	mRNA export from nucleus
H	0008047	molecular_function	enzyme activator activity
H	0015031	biological_process	protein transport
H	0016973	biological_process	poly(A)+ mRNA export from nucleus
H	0032880	biological_process	regulation of protein localization
H	0045893	biological_process	positive regulation of DNA-templated transcription
H	0045944	biological_process	positive regulation of transcription by RNA polymerase II
H	0051028	biological_process	mRNA transport
H	0070390	cellular_component	transcription export complex 2
H	0071028	biological_process	nuclear mRNA surveillance
H	0071819	cellular_component	DUBm complex
I	0000226	biological_process	microtubule cytoskeleton organization
I	0003674	molecular_function	molecular_function
I	0005509	molecular_function	calcium ion binding
I	0005515	molecular_function	protein binding
I	0005635	cellular_component	nuclear envelope
I	0005816	cellular_component	spindle pole body
I	0005825	cellular_component	half bridge of spindle pole body
I	0006406	biological_process	mRNA export from nucleus
I	0008017	molecular_function	microtubule binding
I	0030474	biological_process	spindle pole body duplication
I	0042802	molecular_function	identical protein binding
I	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
I	0044732	cellular_component	mitotic spindle pole body
I	0045944	biological_process	positive regulation of transcription by RNA polymerase II
I	0046872	molecular_function	metal ion binding
I	0048193	biological_process	Golgi vesicle transport
I	0051301	biological_process	cell division
I	0070390	cellular_component	transcription export complex 2
K	0000124	cellular_component	SAGA complex
K	0000932	cellular_component	P-body
K	0000973	biological_process	post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery
K	0003682	molecular_function	chromatin binding
K	0003713	molecular_function	transcription coactivator activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005643	cellular_component	nuclear pore
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0006325	biological_process	chromatin organization
K	0006351	biological_process	DNA-templated transcription
K	0006357	biological_process	regulation of transcription by RNA polymerase II
K	0006368	biological_process	transcription elongation by RNA polymerase II
K	0006406	biological_process	mRNA export from nucleus
K	0008047	molecular_function	enzyme activator activity
K	0015031	biological_process	protein transport
K	0016973	biological_process	poly(A)+ mRNA export from nucleus
K	0032880	biological_process	regulation of protein localization
K	0045893	biological_process	positive regulation of DNA-templated transcription
K	0045944	biological_process	positive regulation of transcription by RNA polymerase II
K	0051028	biological_process	mRNA transport
K	0070390	cellular_component	transcription export complex 2
K	0071028	biological_process	nuclear mRNA surveillance
K	0071819	cellular_component	DUBm complex
L	0000124	cellular_component	SAGA complex
L	0000932	cellular_component	P-body
L	0000973	biological_process	post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery
L	0003682	molecular_function	chromatin binding
L	0003713	molecular_function	transcription coactivator activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005643	cellular_component	nuclear pore
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0006325	biological_process	chromatin organization
L	0006351	biological_process	DNA-templated transcription
L	0006357	biological_process	regulation of transcription by RNA polymerase II
L	0006368	biological_process	transcription elongation by RNA polymerase II
L	0006406	biological_process	mRNA export from nucleus
L	0008047	molecular_function	enzyme activator activity
L	0015031	biological_process	protein transport
L	0016973	biological_process	poly(A)+ mRNA export from nucleus
L	0032880	biological_process	regulation of protein localization
L	0045893	biological_process	positive regulation of DNA-templated transcription
L	0045944	biological_process	positive regulation of transcription by RNA polymerase II
L	0051028	biological_process	mRNA transport
L	0070390	cellular_component	transcription export complex 2
L	0071028	biological_process	nuclear mRNA surveillance
L	0071819	cellular_component	DUBm complex
M	0000226	biological_process	microtubule cytoskeleton organization
M	0003674	molecular_function	molecular_function
M	0005509	molecular_function	calcium ion binding
M	0005515	molecular_function	protein binding
M	0005635	cellular_component	nuclear envelope
M	0005816	cellular_component	spindle pole body
M	0005825	cellular_component	half bridge of spindle pole body
M	0006406	biological_process	mRNA export from nucleus
M	0008017	molecular_function	microtubule binding
M	0030474	biological_process	spindle pole body duplication
M	0042802	molecular_function	identical protein binding
M	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
M	0044732	cellular_component	mitotic spindle pole body
M	0045944	biological_process	positive regulation of transcription by RNA polymerase II
M	0046872	molecular_function	metal ion binding
M	0048193	biological_process	Golgi vesicle transport
M	0051301	biological_process	cell division
M	0070390	cellular_component	transcription export complex 2
O	0000124	cellular_component	SAGA complex
O	0000932	cellular_component	P-body
O	0000973	biological_process	post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery
O	0003682	molecular_function	chromatin binding
O	0003713	molecular_function	transcription coactivator activity
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005643	cellular_component	nuclear pore
O	0005654	cellular_component	nucleoplasm
O	0005737	cellular_component	cytoplasm
O	0006325	biological_process	chromatin organization
O	0006351	biological_process	DNA-templated transcription
O	0006357	biological_process	regulation of transcription by RNA polymerase II
O	0006368	biological_process	transcription elongation by RNA polymerase II
O	0006406	biological_process	mRNA export from nucleus
O	0008047	molecular_function	enzyme activator activity
O	0015031	biological_process	protein transport
O	0016973	biological_process	poly(A)+ mRNA export from nucleus
O	0032880	biological_process	regulation of protein localization
O	0045893	biological_process	positive regulation of DNA-templated transcription
O	0045944	biological_process	positive regulation of transcription by RNA polymerase II
O	0051028	biological_process	mRNA transport
O	0070390	cellular_component	transcription export complex 2
O	0071028	biological_process	nuclear mRNA surveillance
O	0071819	cellular_component	DUBm complex
P	0000124	cellular_component	SAGA complex
P	0000932	cellular_component	P-body
P	0000973	biological_process	post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery
P	0003682	molecular_function	chromatin binding
P	0003713	molecular_function	transcription coactivator activity
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005643	cellular_component	nuclear pore
P	0005654	cellular_component	nucleoplasm
P	0005737	cellular_component	cytoplasm
P	0006325	biological_process	chromatin organization
P	0006351	biological_process	DNA-templated transcription
P	0006357	biological_process	regulation of transcription by RNA polymerase II
P	0006368	biological_process	transcription elongation by RNA polymerase II
P	0006406	biological_process	mRNA export from nucleus
P	0008047	molecular_function	enzyme activator activity
P	0015031	biological_process	protein transport
P	0016973	biological_process	poly(A)+ mRNA export from nucleus
P	0032880	biological_process	regulation of protein localization
P	0045893	biological_process	positive regulation of DNA-templated transcription
P	0045944	biological_process	positive regulation of transcription by RNA polymerase II
P	0051028	biological_process	mRNA transport
P	0070390	cellular_component	transcription export complex 2
P	0071028	biological_process	nuclear mRNA surveillance
P	0071819	cellular_component	DUBm complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 162

Chain	Residue
A	HIS43
A	LYS46
A	LYS58
B	ARG776
B	LEU779
C	LYS30

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 G 97

Chain	Residue
F	LEU779
G	LYS30
E	HIS43
E	LYS58
F	ARG776

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 I 162

Chain	Residue
I	HIS43
I	LYS58
I	HOH163
J	ARG776
K	LYS30

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 M 162

Chain	Residue
M	HIS43
M	LYS58
N	ARG776
N	LEU779
O	LYS30

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DMNNDGFLDyhEL

Chain	Residue	Details
A	ASP33-LEU45
A	ASP142-PHE154

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	140
Details	Domain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	140
Details	Domain: {"description":"EF-hand 2","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	140
Details	Domain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	32
Details	Domain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"14718168","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	16
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---