3FW0
Structure of Peptidyl-alpha-hydroxyglycine alpha-Amidating Lyase (PAL) bound to alpha-hydroxyhippuric acid (non-peptidic substrate)
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE HG A 821 |
| Chain | Residue |
| A | HH31 |
| A | HIS585 |
| A | TYR654 |
| A | HIS690 |
| A | HIS786 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE HG A 822 |
| Chain | Residue |
| A | HIS492 |
| A | HIS495 |
| A | ASP498 |
| A | ILE572 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 823 |
| Chain | Residue |
| A | HOH107 |
| A | HOH108 |
| A | HOH109 |
| A | VAL520 |
| A | LEU587 |
| A | ASP787 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE HH3 A 1 |
| Chain | Residue |
| A | HOH106 |
| A | ARG533 |
| A | TRP538 |
| A | LYS613 |
| A | TYR654 |
| A | ARG706 |
| A | MET784 |
| A | HIS786 |
| A | HG821 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 43 |
| Details | Repeat: {"description":"NHL 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"NHL 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 45 |
| Details | Repeat: {"description":"NHL 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 44 |
| Details | Repeat: {"description":"NHL 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 43 |
| Details | Repeat: {"description":"NHL 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 322 |
| Details | Region: {"description":"Peptidyl-alpha-hydroxyglycine alpha-amidating lyase","evidences":[{"source":"PubMed","id":"19604476","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19604476","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3FVZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FW0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19604476","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3FW0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19604476","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3FVZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"2211657","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Sulfotyrosine","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
