3FW0

Structure of Peptidyl-alpha-hydroxyglycine alpha-Amidating Lyase (PAL) bound to alpha-hydroxyhippuric acid (non-peptidic substrate)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0006518	biological_process	peptide metabolic process
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE HG A 821

Chain	Residue
A	HH31
A	HIS585
A	TYR654
A	HIS690
A	HIS786

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE HG A 822

Chain	Residue
A	HIS492
A	HIS495
A	ASP498
A	ILE572

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 823

Chain	Residue
A	HOH107
A	HOH108
A	HOH109
A	VAL520
A	LEU587
A	ASP787

---

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE HH3 A 1

Chain	Residue
A	HOH106
A	ARG533
A	TRP538
A	LYS613
A	TYR654
A	ARG706
A	MET784
A	HIS786
A	HG821

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:19604476, ECO:0007744|PDB:3FVZ, ECO:0007744|PDB:3FW0

Chain	Residue	Details
A	VAL520
A	LEU587
A	ASP787

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000305|PubMed:19604476, ECO:0007744|PDB:3FW0

Chain	Residue	Details
A	ARG533
A	TYR654
A	ARG706

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:19604476, ECO:0007744|PDB:3FVZ

Chain	Residue	Details
A	HIS585
A	HIS690
A	HIS786

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2211657

Chain	Residue	Details
A	ASN765

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues
Details	M-CSA 135

Chain

Residue

Details

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