3FUC
Recombinant calf purine nucleoside phosphorylase in a binary complex with multisubstrate analogue inhibitor 9-(5',5'-difluoro-5'-phosphonopentyl)-9-deazaguanine structure in a new space group with one full trimer in the asymmetric unit
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
A | 0006166 | biological_process | purine ribonucleoside salvage |
A | 0009116 | biological_process | nucleoside metabolic process |
A | 0016757 | molecular_function | glycosyltransferase activity |
A | 0016763 | molecular_function | pentosyltransferase activity |
A | 0047975 | molecular_function | guanosine phosphorylase activity |
B | 0003824 | molecular_function | catalytic activity |
B | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0006139 | biological_process | nucleobase-containing compound metabolic process |
B | 0006166 | biological_process | purine ribonucleoside salvage |
B | 0009116 | biological_process | nucleoside metabolic process |
B | 0016757 | molecular_function | glycosyltransferase activity |
B | 0016763 | molecular_function | pentosyltransferase activity |
B | 0047975 | molecular_function | guanosine phosphorylase activity |
C | 0003824 | molecular_function | catalytic activity |
C | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0006139 | biological_process | nucleobase-containing compound metabolic process |
C | 0006166 | biological_process | purine ribonucleoside salvage |
C | 0009116 | biological_process | nucleoside metabolic process |
C | 0016757 | molecular_function | glycosyltransferase activity |
C | 0016763 | molecular_function | pentosyltransferase activity |
C | 0047975 | molecular_function | guanosine phosphorylase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE 9D9 A 301 |
Chain | Residue |
A | SER33 |
A | PHE200 |
A | GLU201 |
A | VAL217 |
A | GLY218 |
A | MET219 |
A | SER220 |
A | THR242 |
A | ASN243 |
A | VAL245 |
A | HOH428 |
A | ARG84 |
A | HOH440 |
A | HOH556 |
A | HIS86 |
A | TYR88 |
A | ASN115 |
A | ALA116 |
A | ALA117 |
A | GLY118 |
A | LEU195 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG A 302 |
Chain | Residue |
A | GLU186 |
A | HOH425 |
A | HOH503 |
A | HOH549 |
B | GLU186 |
B | HOH626 |
site_id | AC3 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE 9D9 B 301 |
Chain | Residue |
B | SER33 |
B | ARG84 |
B | HIS86 |
B | TYR88 |
B | ASN115 |
B | ALA116 |
B | ALA117 |
B | GLY118 |
B | LEU195 |
B | PHE200 |
B | GLU201 |
B | VAL217 |
B | GLY218 |
B | MET219 |
B | SER220 |
B | THR242 |
B | ASN243 |
B | HOH510 |
B | HOH533 |
B | HOH619 |
site_id | AC4 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE 9D9 C 301 |
Chain | Residue |
C | SER33 |
C | ARG84 |
C | HIS86 |
C | TYR88 |
C | ASN115 |
C | ALA116 |
C | ALA117 |
C | GLY118 |
C | LEU195 |
C | PHE200 |
C | GLU201 |
C | VAL217 |
C | GLY218 |
C | MET219 |
C | SER220 |
C | THR242 |
C | ASN243 |
C | VAL245 |
C | HOH401 |
C | HOH486 |
C | HOH493 |
site_id | AC5 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE MG C 302 |
Chain | Residue |
C | ASP9 |
C | ASP9 |
C | HOH407 |
C | HOH407 |
C | HOH511 |
C | HOH511 |
C | HOH530 |
C | HOH530 |
site_id | AC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG C 303 |
Chain | Residue |
C | GLU186 |
C | GLU186 |
C | HOH504 |
C | HOH504 |
C | HOH505 |
C | HOH505 |
site_id | AC7 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE AZI C 304 |
Chain | Residue |
C | PRO92 |
C | LYS95 |
Functional Information from PROSITE/UniProt
site_id | PS01240 |
Number of Residues | 42 |
Details | PNP_MTAP_2 Purine and other phosphorylases family 2 signature. VmmqGrfHmYegypFwkvTfpVrVfrllGvet.LVvtNAaGGL |
Chain | Residue | Details |
A | VAL79-LEU120 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:9585525, ECO:0007744|PDB:1A9O, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9S, ECO:0007744|PDB:1A9T, ECO:0007744|PDB:3PNP, ECO:0007744|PDB:4PNP |
Chain | Residue | Details |
A | SER33 | |
B | SER33 | |
C | SER33 |
site_id | SWS_FT_FI2 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:9585525, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9T, ECO:0007744|PDB:3PNP, ECO:0007744|PDB:4PNP |
Chain | Residue | Details |
A | HIS64 | |
B | HIS64 | |
C | HIS64 |
site_id | SWS_FT_FI3 |
Number of Residues | 9 |
Details | BINDING: BINDING => ECO:0000269|PubMed:9585525, ECO:0007744|PDB:1A9O, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9Q, ECO:0007744|PDB:1A9R, ECO:0007744|PDB:1A9S, ECO:0007744|PDB:1A9T, ECO:0007744|PDB:3PNP, ECO:0007744|PDB:4PNP |
Chain | Residue | Details |
A | ARG84 | |
A | ALA116 | |
A | SER220 | |
B | ARG84 | |
B | ALA116 | |
B | SER220 | |
C | ARG84 | |
C | ALA116 | |
C | SER220 |
site_id | SWS_FT_FI4 |
Number of Residues | 9 |
Details | BINDING: BINDING => ECO:0000269|PubMed:9585525, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9S, ECO:0007744|PDB:1A9T |
Chain | Residue | Details |
A | TYR88 | |
A | MET219 | |
A | HIS257 | |
B | TYR88 | |
B | MET219 | |
B | HIS257 | |
C | TYR88 | |
C | MET219 | |
C | HIS257 |
site_id | SWS_FT_FI5 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:9585525, ECO:0000305|PubMed:9020983, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9Q, ECO:0007744|PDB:1A9R, ECO:0007744|PDB:1VFN |
Chain | Residue | Details |
A | GLU201 | |
A | ASN243 | |
B | GLU201 | |
B | ASN243 | |
C | GLU201 | |
C | ASN243 |
site_id | SWS_FT_FI6 |
Number of Residues | 3 |
Details | SITE: Important for substrate specificity => ECO:0000250|UniProtKB:P00491 |
Chain | Residue | Details |
A | ASN243 | |
B | ASN243 | |
C | ASN243 |
site_id | SWS_FT_FI7 |
Number of Residues | 3 |
Details | MOD_RES: N-acetylmethionine => ECO:0000250|UniProtKB:P00491 |
Chain | Residue | Details |
A | MET1 | |
B | MET1 | |
C | MET1 |
site_id | SWS_FT_FI8 |
Number of Residues | 3 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P00491 |
Chain | Residue | Details |
A | SER251 | |
B | SER251 | |
C | SER251 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1cg6 |
Chain | Residue | Details |
A | ASN243 | |
A | HIS86 | |
A | GLU89 |
site_id | CSA2 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1cg6 |
Chain | Residue | Details |
B | ASN243 | |
B | HIS86 | |
B | GLU89 |
site_id | CSA3 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1cg6 |
Chain | Residue | Details |
C | ASN243 | |
C | HIS86 | |
C | GLU89 |
site_id | CSA4 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1cg6 |
Chain | Residue | Details |
A | ASN243 | |
A | ASP248 |
site_id | CSA5 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1cg6 |
Chain | Residue | Details |
B | ASN243 | |
B | ASP248 |
site_id | CSA6 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1cg6 |
Chain | Residue | Details |
C | ASN243 | |
C | ASP248 |