3FRU

NEONATAL FC RECEPTOR, PH 6.5

Replaces:  1FRU

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
B	0005576	cellular_component	extracellular region
B	0005765	cellular_component	lysosomal membrane
B	0006955	biological_process	immune response
B	0009410	biological_process	response to xenobiotic stimulus
B	0010038	biological_process	response to metal ion
B	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
B	0023026	molecular_function	MHC class II protein complex binding
B	0031902	cellular_component	late endosome membrane
B	0042605	molecular_function	peptide antigen binding
B	0042612	cellular_component	MHC class I protein complex
B	0042613	cellular_component	MHC class II protein complex
B	0046686	biological_process	response to cadmium ion
B	0050778	biological_process	positive regulation of immune response
B	0050870	biological_process	positive regulation of T cell activation
D	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
D	0005576	cellular_component	extracellular region
D	0005765	cellular_component	lysosomal membrane
D	0006955	biological_process	immune response
D	0009410	biological_process	response to xenobiotic stimulus
D	0010038	biological_process	response to metal ion
D	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
D	0023026	molecular_function	MHC class II protein complex binding
D	0031902	cellular_component	late endosome membrane
D	0042605	molecular_function	peptide antigen binding
D	0042612	cellular_component	MHC class I protein complex
D	0042613	cellular_component	MHC class II protein complex
D	0046686	biological_process	response to cadmium ion
D	0050778	biological_process	positive regulation of immune response
D	0050870	biological_process	positive regulation of T cell activation
F	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
F	0005576	cellular_component	extracellular region
F	0005765	cellular_component	lysosomal membrane
F	0006955	biological_process	immune response
F	0009410	biological_process	response to xenobiotic stimulus
F	0010038	biological_process	response to metal ion
F	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
F	0023026	molecular_function	MHC class II protein complex binding
F	0031902	cellular_component	late endosome membrane
F	0042605	molecular_function	peptide antigen binding
F	0042612	cellular_component	MHC class I protein complex
F	0042613	cellular_component	MHC class II protein complex
F	0046686	biological_process	response to cadmium ion
F	0050778	biological_process	positive regulation of immune response
F	0050870	biological_process	positive regulation of T cell activation

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVKH

Chain	Residue	Details
B	TYR78-HIS84
A	TYR252-HIS258

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	261
Details	Domain: {"description":"Ig-like C1-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	264
Details	Region: {"description":"Alpha-1","evidences":[{"source":"PubMed","id":"7969498","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9493268","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FRT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FRU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	267
Details	Region: {"description":"Alpha-2","evidences":[{"source":"PubMed","id":"7969498","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9493268","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FRT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FRU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	267
Details	Region: {"description":"Alpha-3","evidences":[{"source":"PubMed","id":"7969498","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9493268","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FRT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FRU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	267
Details	Domain: {"description":"Ig-like C1-type"}

Chain

Residue

Details

---