Functional Information from GO Data
| Chain | GOid | namespace | contents |
| X | 0004146 | molecular_function | dihydrofolate reductase activity |
| X | 0005829 | cellular_component | cytosol |
| X | 0006730 | biological_process | one-carbon metabolic process |
| X | 0016491 | molecular_function | oxidoreductase activity |
| X | 0044281 | biological_process | small molecule metabolic process |
| X | 0046452 | biological_process | dihydrofolate metabolic process |
| X | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| X | 0046655 | biological_process | folic acid metabolic process |
| X | 0050661 | molecular_function | NADP binding |
| X | 0070401 | molecular_function | NADP+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 32 |
| Details | BINDING SITE FOR RESIDUE NAP X 301 |
| Chain | Residue |
| X | VAL6 |
| X | ARG44 |
| X | LYS45 |
| X | THR46 |
| X | LEU62 |
| X | THR63 |
| X | SER64 |
| X | ILE79 |
| X | PHE92 |
| X | GLY93 |
| X | GLY94 |
| X | ALA7 |
| X | GLN95 |
| X | THR96 |
| X | TYR98 |
| X | GLU100 |
| X | THR121 |
| X | HOH167 |
| X | HOH171 |
| X | HOH172 |
| X | HOH203 |
| X | HOH210 |
| X | ILE14 |
| X | HOH248 |
| X | HOH249 |
| X | TOP300 |
| X | GLY15 |
| X | PHE16 |
| X | ASN18 |
| X | GLN19 |
| X | LEU20 |
| X | GLY43 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE TOP X 300 |
| Chain | Residue |
| X | LEU5 |
| X | VAL6 |
| X | ALA7 |
| X | ASP27 |
| X | LEU28 |
| X | VAL31 |
| X | SER49 |
| X | ILE50 |
| X | PHE92 |
| X | TYR98 |
| X | THR111 |
| X | HOH169 |
| X | HOH170 |
| X | HOH184 |
| X | NAP301 |
Functional Information from PROSITE/UniProt
| site_id | PS00075 |
| Number of Residues | 23 |
| Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGfenqLPWhlpn.DlkhVkklS |
| Chain | Residue | Details |
| X | VAL13-SER35 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 155 |
| Details | Domain: {"description":"DHFR","evidences":[{"source":"PROSITE-ProRule","id":"PRU00660","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19280600","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 19 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19280600","evidenceCode":"ECO:0000269"}]} |
