Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004146 | molecular_function | dihydrofolate reductase activity |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE 11F A 219 |
| Chain | Residue |
| A | LEU5 |
| A | ILE50 |
| A | LEU54 |
| A | PHE92 |
| A | THR111 |
| A | HOH158 |
| A | NDP207 |
| A | HOH289 |
| A | VAL6 |
| A | ALA7 |
| A | GLN19 |
| A | LEU20 |
| A | ASP27 |
| A | VAL31 |
| A | THR46 |
| A | SER49 |
| site_id | AC2 |
| Number of Residues | 36 |
| Details | BINDING SITE FOR RESIDUE NDP A 207 |
| Chain | Residue |
| A | VAL6 |
| A | ALA7 |
| A | ILE14 |
| A | GLY15 |
| A | ASN18 |
| A | GLN19 |
| A | LEU20 |
| A | TRP22 |
| A | GLY43 |
| A | ARG44 |
| A | LYS45 |
| A | THR46 |
| A | LEU62 |
| A | THR63 |
| A | SER64 |
| A | SER67 |
| A | HIS77 |
| A | ILE79 |
| A | PHE92 |
| A | GLY94 |
| A | GLN95 |
| A | THR96 |
| A | LEU97 |
| A | GLU100 |
| A | THR121 |
| A | HOH164 |
| A | HOH165 |
| A | HOH190 |
| A | HOH202 |
| A | HOH205 |
| A | HOH208 |
| A | 11F219 |
| A | HOH238 |
| A | HOH252 |
| A | HOH289 |
| A | HOH290 |
Functional Information from PROSITE/UniProt
| site_id | PS00075 |
| Number of Residues | 23 |
| Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGfenqLPWhlpn.DlkhVkklS |
| Chain | Residue | Details |
| A | VAL13-SER35 | |
