3FMP
Crystal structure of the nucleoporin Nup214 in complex with the DEAD-box helicase Ddx19
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003724 | molecular_function | RNA helicase activity |
| B | 0003729 | molecular_function | mRNA binding |
| B | 0004386 | molecular_function | helicase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005643 | cellular_component | nuclear pore |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006406 | biological_process | mRNA export from nucleus |
| B | 0010494 | cellular_component | cytoplasmic stress granule |
| B | 0016020 | cellular_component | membrane |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016887 | molecular_function | ATP hydrolysis activity |
| B | 0016973 | biological_process | poly(A)+ mRNA export from nucleus |
| B | 0070062 | cellular_component | extracellular exosome |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0003676 | molecular_function | nucleic acid binding |
| D | 0003723 | molecular_function | RNA binding |
| D | 0003724 | molecular_function | RNA helicase activity |
| D | 0003729 | molecular_function | mRNA binding |
| D | 0004386 | molecular_function | helicase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005643 | cellular_component | nuclear pore |
| D | 0005654 | cellular_component | nucleoplasm |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006406 | biological_process | mRNA export from nucleus |
| D | 0010494 | cellular_component | cytoplasmic stress granule |
| D | 0016020 | cellular_component | membrane |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0016887 | molecular_function | ATP hydrolysis activity |
| D | 0016973 | biological_process | poly(A)+ mRNA export from nucleus |
| D | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE ADP B 480 |
| Chain | Residue |
| B | LEU70 |
| B | LYS144 |
| B | THR145 |
| B | ALA146 |
| B | PHE94 |
| B | PHE112 |
| B | ARG114 |
| B | GLN119 |
| B | GLN139 |
| B | GLY141 |
| B | THR142 |
| B | GLY143 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE ADP D 480 |
| Chain | Residue |
| D | LEU70 |
| D | PHE94 |
| D | PHE112 |
| D | ARG114 |
| D | SER116 |
| D | GLN119 |
| D | GLN139 |
| D | SER140 |
| D | GLY141 |
| D | THR142 |
| D | GLY143 |
| D | LYS144 |
| D | THR145 |
| D | ALA146 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | BINDING: |
| Chain | Residue | Details |
| B | GLN119 | |
| B | SER138 | |
| B | ARG429 | |
| B | ARG432 | |
| D | GLN119 | |
| D | SER138 | |
| D | ARG429 | |
| D | ARG432 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylalanine => ECO:0007744|PubMed:22223895 |
| Chain | Residue | Details |
| B | ALA2 | |
| D | ALA2 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER30 | |
| A | SER421 | |
| C | SER30 | |
| C | SER421 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | THR416 | |
| C | THR416 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER430 | |
| C | SER430 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER433 | |
| C | SER433 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | THR434 | |
| A | THR437 | |
| C | THR434 | |
| C | THR437 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| A | THR439 | |
| C | THR439 |
