Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3FLO

Crystal structure of the carboxyl-terminal domain of yeast DNA polymerase alpha in complex with its B subunit

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0006260	biological_process	DNA replication
B	0003887	molecular_function	DNA-directed DNA polymerase activity
B	0006260	biological_process	DNA replication
C	0003677	molecular_function	DNA binding
C	0006260	biological_process	DNA replication
D	0003887	molecular_function	DNA-directed DNA polymerase activity
D	0006260	biological_process	DNA replication
E	0003677	molecular_function	DNA binding
E	0006260	biological_process	DNA replication
F	0003887	molecular_function	DNA-directed DNA polymerase activity
F	0006260	biological_process	DNA replication
G	0003677	molecular_function	DNA binding
G	0006260	biological_process	DNA replication
H	0003887	molecular_function	DNA-directed DNA polymerase activity
H	0006260	biological_process	DNA replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 3

Chain	Residue
A	ARG559
A	GLU562
A	HIS563
A	GLN566

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 5

Chain	Residue
A	ARG554
A	TYR555
A	ARG556

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 12

Chain	Residue
A	LYS512
A	HOH133
A	ARG505

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 13

Chain	Residue
A	ARG505
A	LYS506

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 30

Chain	Residue
A	LYS455
A	THR456
A	GLN457
A	HOH717

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 31

Chain	Residue
A	LYS455
A	THR456
A	LYS467
A	HOH760

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 32

Chain	Residue
A	ALA501
A	SER502

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 34

Chain	Residue
A	GLU293
A	LYS353

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 35

Chain	Residue
A	ILE271
A	PRO369
A	TYR370
A	ARG568

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 47

Chain	Residue
A	SER290
A	GLN291
A	SER292

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 48

Chain	Residue
A	ASP537
A	PRO634
A	SER635
A	GLU636
A	ARG654
A	HOH1027

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 49

Chain	Residue
A	SO450
A	ARG657
A	ALA658

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 50

Chain	Residue
A	SO449
A	ARG657
A	THR659
A	ASN661

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1

Chain	Residue
B	CYS1287
B	CYS1290
B	CYS1314
B	CYS1317

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 2

Chain	Residue
B	CYS1348
B	CYS1353
B	CYS1367
B	CYS1372

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 37

Chain	Residue
B	SO438
B	ASP1397
B	CYS1398
B	GLU1399
B	ARG1435

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 38

Chain	Residue
B	SO437
B	ASP1397
B	ARG1442

site_id	BC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 57

Chain	Residue
B	THR1423
B	GLU1424

site_id	CC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 59

Chain	Residue
B	ARG1306
B	LYS1315

site_id	CC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 62

Chain	Residue
B	ALA1336
B	HIS1337

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 68

Chain	Residue
B	TRP1345
B	VAL1356
B	LYS1379

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 6

Chain	Residue
C	ARG559
C	GLU562
C	HIS563
C	GLN566

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 8

Chain	Residue
C	HOH147
C	ARG554
C	TYR555
C	ARG556

site_id	CC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 C 9

Chain	Residue
C	ARG554

site_id	CC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 10

Chain	Residue
C	GLN645
C	HOH724

site_id	CC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 11

Chain	Residue
C	ARG505
C	LYS506

site_id	CC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 15

Chain	Residue
C	HOH123
C	LYS455
C	THR456
C	GLN457

site_id	DC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 43

Chain	Residue
C	SER392
C	THR669
C	GLN671

site_id	DC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 46

Chain	Residue
C	LYS455
C	THR456

site_id	DC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 52

Chain	Residue
C	PRO634
C	SER635
C	ARG654
C	HOH706

site_id	DC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 53

Chain	Residue
C	ARG657
C	ALA658
C	THR659

site_id	DC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 69

Chain	Residue
C	GLN291
C	SER292
C	SER290

site_id	DC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 1

Chain	Residue
D	CYS1287
D	CYS1290
D	CYS1314
D	CYS1317

site_id	DC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 2

Chain	Residue
D	CYS1348
D	CYS1353
D	CYS1367
D	CYS1372

site_id	DC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D 39

Chain	Residue
D	ARG1306
D	LYS1315

site_id	DC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 40

Chain	Residue
D	ASP1397
D	CYS1398
D	GLU1399
D	ARG1435

site_id	EC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 D 63

Chain	Residue
D	HIS1337

site_id	EC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 67

Chain	Residue
D	HOH1194
D	TRP1345
D	VAL1356
D	LYS1379

site_id	EC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 4

Chain	Residue
E	SER341
E	GLU562
E	HIS563
E	GLN566

site_id	EC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 E 20

Chain	Residue
E	PRO449
E	ASN450

site_id	EC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 E 22

Chain	Residue
E	GLY400
E	PRO634
E	SER635
E	GLU636
E	ARG654

site_id	EC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 23

Chain	Residue
E	THR456
E	GLN457
E	HOH710
E	HOH717

site_id	EC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 24

Chain	Residue
E	LYS455
E	THR456
E	LYS467

site_id	EC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 25

Chain	Residue
E	ARG505
E	LYS512
E	HOH1092
E	HOH1093

site_id	EC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 26

Chain	Residue
E	ARG505
E	LYS506
E	LYS512

site_id	FC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 E 33

Chain	Residue
E	ALA501
E	SER502

site_id	FC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 E 44

Chain	Residue
E	ARG662

site_id	FC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 45

Chain	Residue
E	ARG554
E	TYR555
E	ARG556

site_id	FC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 E 54

Chain	Residue
E	ARG657
E	ALA658

site_id	FC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 E 58

Chain	Residue
E	HOH240
E	ARG554

site_id	FC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 1

Chain	Residue
F	CYS1287
F	CYS1290
F	CYS1314
F	CYS1317

site_id	FC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 2

Chain	Residue
F	CYS1348
F	CYS1353
F	CYS1367
F	CYS1372

site_id	FC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 F 28

Chain	Residue
F	ASP1397
F	CYS1398
F	ARG1435
F	ARG1442

site_id	FC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 F 41

Chain	Residue
F	ARG1306
F	LYS1315
F	GLU1420

site_id	GC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 F 64

Chain	Residue
F	ALA1336
F	HIS1337
F	LEU1340

site_id	GC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 F 66

Chain	Residue
F	TRP1345
F	VAL1356
F	LYS1379

site_id	GC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 G 1

Chain	Residue
G	ARG559
G	GLU562
G	HIS563
G	GLN566

site_id	GC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 G 2

Chain	Residue
G	HOH20
G	ARG554
G	ASP558

site_id	GC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 G 7

Chain	Residue
G	HOH23
G	ARG554
G	TYR555
G	ARG556

site_id	GC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 G 16

Chain	Residue
G	ARG505
G	HOH889

site_id	GC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 G 17

Chain	Residue
G	LYS455
G	THR456

site_id	GC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 G 18

Chain	Residue
G	ARG505
G	LYS506
G	HOH822

site_id	GC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 G 27

Chain	Residue
G	HOH77
G	THR456
G	GLN457

site_id	HC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 G 42

Chain	Residue
G	SER290
G	GLN291
G	SER292

site_id	HC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 G 51

Chain	Residue
G	PRO634
G	SER635
G	GLU636
G	ARG654
G	HOH840

site_id	HC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 G 55

Chain	Residue
G	SO456
G	ARG657
G	ALA658
G	THR659

site_id	HC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 G 56

Chain	Residue
G	SO455
G	ARG657
G	THR659
G	ASN661

site_id	HC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 1

Chain	Residue
H	CYS1287
H	CYS1290
H	CYS1314
H	CYS1317

site_id	HC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 2

Chain	Residue
H	CYS1348
H	CYS1353
H	CYS1367
H	CYS1372

site_id	HC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 H 19

Chain	Residue
H	ASP1397
H	CYS1398
H	GLU1399
H	ARG1435
H	ARG1442

site_id	HC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 H 60

Chain	Residue
G	LYS277
H	ARG1306
H	LYS1315

site_id	HC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 H 61

Chain	Residue
H	ALA1336
H	HIS1337

site_id	IC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 H 65

Chain	Residue
H	TRP1345
H	LYS1379

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	120
Details	ZN_FING: CysA-type => ECO:0000250\|UniProtKB:P15436

Chain	Residue	Details
B	CYS1287-CYS1317
D	CYS1287-CYS1317
F	CYS1287-CYS1317
H	CYS1287-CYS1317

site_id	SWS_FT_FI2
Number of Residues	32
Details	BINDING: BINDING => ECO:0000269\|PubMed:19494830, ECO:0007744\|PDB:3FLO

Chain	Residue	Details
B	CYS1287
D	CYS1290
D	CYS1314
D	CYS1317
D	CYS1348
D	CYS1353
D	CYS1367
D	CYS1372
F	CYS1287
F	CYS1290
F	CYS1314
B	CYS1290
F	CYS1317
F	CYS1348
F	CYS1353
F	CYS1367
F	CYS1372
H	CYS1287
H	CYS1290
H	CYS1314
H	CYS1317
H	CYS1348
B	CYS1314
H	CYS1353
H	CYS1367
H	CYS1372
B	CYS1317
B	CYS1348
B	CYS1353
B	CYS1367
B	CYS1372
D	CYS1287

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)