Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3FKY

Crystal structure of the glutamine synthetase Gln1deltaN18 from the yeast Saccharomyces cerevisiae

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003824	molecular_function	catalytic activity
A	0004356	molecular_function	glutamine synthetase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006542	biological_process	glutamine biosynthetic process
A	0016874	molecular_function	ligase activity
A	0034399	cellular_component	nuclear periphery
B	0000166	molecular_function	nucleotide binding
B	0003824	molecular_function	catalytic activity
B	0004356	molecular_function	glutamine synthetase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0006542	biological_process	glutamine biosynthetic process
B	0016874	molecular_function	ligase activity
B	0034399	cellular_component	nuclear periphery
C	0000166	molecular_function	nucleotide binding
C	0003824	molecular_function	catalytic activity
C	0004356	molecular_function	glutamine synthetase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0006542	biological_process	glutamine biosynthetic process
C	0016874	molecular_function	ligase activity
C	0034399	cellular_component	nuclear periphery
D	0000166	molecular_function	nucleotide binding
D	0003824	molecular_function	catalytic activity
D	0004356	molecular_function	glutamine synthetase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0006542	biological_process	glutamine biosynthetic process
D	0016874	molecular_function	ligase activity
D	0034399	cellular_component	nuclear periphery
E	0000166	molecular_function	nucleotide binding
E	0003824	molecular_function	catalytic activity
E	0004356	molecular_function	glutamine synthetase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0006542	biological_process	glutamine biosynthetic process
E	0016874	molecular_function	ligase activity
E	0034399	cellular_component	nuclear periphery
F	0000166	molecular_function	nucleotide binding
F	0003824	molecular_function	catalytic activity
F	0004356	molecular_function	glutamine synthetase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0006542	biological_process	glutamine biosynthetic process
F	0016874	molecular_function	ligase activity
F	0034399	cellular_component	nuclear periphery
G	0000166	molecular_function	nucleotide binding
G	0003824	molecular_function	catalytic activity
G	0004356	molecular_function	glutamine synthetase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0006542	biological_process	glutamine biosynthetic process
G	0016874	molecular_function	ligase activity
G	0034399	cellular_component	nuclear periphery
H	0000166	molecular_function	nucleotide binding
H	0003824	molecular_function	catalytic activity
H	0004356	molecular_function	glutamine synthetase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0006542	biological_process	glutamine biosynthetic process
H	0016874	molecular_function	ligase activity
H	0034399	cellular_component	nuclear periphery
I	0000166	molecular_function	nucleotide binding
I	0003824	molecular_function	catalytic activity
I	0004356	molecular_function	glutamine synthetase activity
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0006542	biological_process	glutamine biosynthetic process
I	0016874	molecular_function	ligase activity
I	0034399	cellular_component	nuclear periphery
J	0000166	molecular_function	nucleotide binding
J	0003824	molecular_function	catalytic activity
J	0004356	molecular_function	glutamine synthetase activity
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0006542	biological_process	glutamine biosynthetic process
J	0016874	molecular_function	ligase activity
J	0034399	cellular_component	nuclear periphery
K	0000166	molecular_function	nucleotide binding
K	0003824	molecular_function	catalytic activity
K	0004356	molecular_function	glutamine synthetase activity
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0006542	biological_process	glutamine biosynthetic process
K	0016874	molecular_function	ligase activity
K	0034399	cellular_component	nuclear periphery
L	0000166	molecular_function	nucleotide binding
L	0003824	molecular_function	catalytic activity
L	0004356	molecular_function	glutamine synthetase activity
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0006542	biological_process	glutamine biosynthetic process
L	0016874	molecular_function	ligase activity
L	0034399	cellular_component	nuclear periphery
M	0000166	molecular_function	nucleotide binding
M	0003824	molecular_function	catalytic activity
M	0004356	molecular_function	glutamine synthetase activity
M	0005515	molecular_function	protein binding
M	0005524	molecular_function	ATP binding
M	0005634	cellular_component	nucleus
M	0005737	cellular_component	cytoplasm
M	0006542	biological_process	glutamine biosynthetic process
M	0016874	molecular_function	ligase activity
M	0034399	cellular_component	nuclear periphery
N	0000166	molecular_function	nucleotide binding
N	0003824	molecular_function	catalytic activity
N	0004356	molecular_function	glutamine synthetase activity
N	0005515	molecular_function	protein binding
N	0005524	molecular_function	ATP binding
N	0005634	cellular_component	nucleus
N	0005737	cellular_component	cytoplasm
N	0006542	biological_process	glutamine biosynthetic process
N	0016874	molecular_function	ligase activity
N	0034399	cellular_component	nuclear periphery
O	0000166	molecular_function	nucleotide binding
O	0003824	molecular_function	catalytic activity
O	0004356	molecular_function	glutamine synthetase activity
O	0005515	molecular_function	protein binding
O	0005524	molecular_function	ATP binding
O	0005634	cellular_component	nucleus
O	0005737	cellular_component	cytoplasm
O	0006542	biological_process	glutamine biosynthetic process
O	0016874	molecular_function	ligase activity
O	0034399	cellular_component	nuclear periphery
P	0000166	molecular_function	nucleotide binding
P	0003824	molecular_function	catalytic activity
P	0004356	molecular_function	glutamine synthetase activity
P	0005515	molecular_function	protein binding
P	0005524	molecular_function	ATP binding
P	0005634	cellular_component	nucleus
P	0005737	cellular_component	cytoplasm
P	0006542	biological_process	glutamine biosynthetic process
P	0016874	molecular_function	ligase activity
P	0034399	cellular_component	nuclear periphery
Q	0000166	molecular_function	nucleotide binding
Q	0003824	molecular_function	catalytic activity
Q	0004356	molecular_function	glutamine synthetase activity
Q	0005515	molecular_function	protein binding
Q	0005524	molecular_function	ATP binding
Q	0005634	cellular_component	nucleus
Q	0005737	cellular_component	cytoplasm
Q	0006542	biological_process	glutamine biosynthetic process
Q	0016874	molecular_function	ligase activity
Q	0034399	cellular_component	nuclear periphery
R	0000166	molecular_function	nucleotide binding
R	0003824	molecular_function	catalytic activity
R	0004356	molecular_function	glutamine synthetase activity
R	0005515	molecular_function	protein binding
R	0005524	molecular_function	ATP binding
R	0005634	cellular_component	nucleus
R	0005737	cellular_component	cytoplasm
R	0006542	biological_process	glutamine biosynthetic process
R	0016874	molecular_function	ligase activity
R	0034399	cellular_component	nuclear periphery
S	0000166	molecular_function	nucleotide binding
S	0003824	molecular_function	catalytic activity
S	0004356	molecular_function	glutamine synthetase activity
S	0005515	molecular_function	protein binding
S	0005524	molecular_function	ATP binding
S	0005634	cellular_component	nucleus
S	0005737	cellular_component	cytoplasm
S	0006542	biological_process	glutamine biosynthetic process
S	0016874	molecular_function	ligase activity
S	0034399	cellular_component	nuclear periphery
T	0000166	molecular_function	nucleotide binding
T	0003824	molecular_function	catalytic activity
T	0004356	molecular_function	glutamine synthetase activity
T	0005515	molecular_function	protein binding
T	0005524	molecular_function	ATP binding
T	0005634	cellular_component	nucleus
T	0005737	cellular_component	cytoplasm
T	0006542	biological_process	glutamine biosynthetic process
T	0016874	molecular_function	ligase activity
T	0034399	cellular_component	nuclear periphery

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE FLC A 371

Chain	Residue
A	GLU133
A	GLU193
A	GLN198
A	ASN245
A	GLY246
A	ALA247
A	HIS250
A	ARG292
A	ARG333

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FLC B 371

Chain	Residue
B	GLU133
B	GLU193
B	GLN198
B	ASN245
B	GLY246
B	ALA247
B	HIS250
B	ARG292

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE FLC C 371

Chain	Residue
C	GLU133
C	GLU193
C	GLN198
C	ASN245
C	GLY246
C	ALA247
C	GLY248
C	HIS250
C	ARG292

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FLC D 371

Chain	Residue
D	GLU133
D	GLU193
D	GLN198
D	ASN245
D	GLY246
D	ALA247
D	HIS250
D	ARG292

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FLC E 371

Chain	Residue
E	GLU133
E	GLN198
E	ASN245
E	GLY246
E	ALA247
E	GLY248
E	HIS250
E	ARG292

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FLC F 371

Chain	Residue
F	GLU133
F	GLU193
F	GLN198
F	ASN245
F	GLY246
F	ALA247
F	HIS250
F	ARG292

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FLC G 371

Chain	Residue
G	GLU133
G	GLU193
G	GLN198
G	ASN245
G	GLY246
G	HIS250
G	ARG292

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FLC H 371

Chain	Residue
H	GLU133
H	GLU193
H	GLN198
H	GLY246
H	ALA247
H	HIS250
H	ARG292

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FLC I 371

Chain	Residue
I	GLU133
I	GLU193
I	GLN198
I	ASN245
I	GLY246
I	ALA247
I	HIS250
I	ARG292

site_id	BC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FLC J 371

Chain	Residue
J	GLU133
J	GLU193
J	GLN198
J	ASN245
J	GLY246
J	ALA247
J	HIS250
J	ARG292

site_id	BC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE FLC K 371

Chain	Residue
K	GLU133
K	GLU193
K	GLN198
K	ASN245
K	GLY246
K	ALA247
K	GLY248
K	HIS250
K	ARG292
K	ARG333

site_id	BC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE FLC L 371

Chain	Residue
L	GLU133
L	GLU193
L	GLN198
L	ASN245
L	GLY246
L	ALA247
L	HIS250
L	ARG292
L	ARG333

site_id	BC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FLC M 371

Chain	Residue
M	GLU133
M	GLU193
M	GLN198
M	ASN245
M	GLY246
M	ALA247
M	HIS250
M	ARG292

site_id	BC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FLC N 371

Chain	Residue
N	GLU133
N	GLU193
N	GLN198
N	ASN245
N	GLY246
N	ALA247
N	HIS250
N	ARG292

site_id	BC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FLC O 371

Chain	Residue
O	GLU133
O	GLU193
O	GLN198
O	ASN245
O	GLY246
O	ALA247
O	HIS250
O	ARG292

site_id	BC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FLC P 371

Chain	Residue
P	GLU133
P	GLU193
P	GLN198
P	ASN245
P	GLY246
P	ALA247
P	HIS250
P	ARG292

site_id	BC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FLC Q 371

Chain	Residue
Q	GLU133
Q	GLU193
Q	GLN198
Q	ASN245
Q	GLY246
Q	HIS250
Q	ARG292
Q	ARG333

site_id	BC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FLC R 371

Chain	Residue
R	GLU133
R	GLU193
R	GLN198
R	ASN245
R	GLY246
R	HIS250
R	ARG292
R	ARG333

site_id	CC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE FLC S 371

Chain	Residue
S	GLU133
S	GLU193
S	GLN198
S	ASN245
S	GLY246
S	ALA247
S	GLY248
S	HIS250
S	ARG292

site_id	CC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FLC T 371

Chain	Residue
T	GLU133
T	GLU193
T	GLN198
T	ASN245
T	GLY246
T	ALA247
T	HIS250
T	ARG292

Functional Information from PROSITE/UniProt

site_id	PS00180
Number of Residues	18
Details	GLNA_1 Glutamine synthetase signature 1. FDGSStnqapgh.DSDiyL

Chain	Residue	Details
A	PHE59-LEU76

site_id	PS00181
Number of Residues	17
Details	GLNA_ATP Glutamine synthetase putative ATP-binding region signature. KPLkgdw.NGAGcHanvS

Chain	Residue	Details
A	LYS238-SER254

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	79
Details	Domain: {"description":"GS beta-grasp","evidences":[{"source":"PROSITE-ProRule","id":"PRU01330","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
A	ASP60
A	ARG312

site_id	CSA10
Number of Residues	2
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
J	ASP60
J	ARG312

site_id	CSA11
Number of Residues	2
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
K	ASP60
K	ARG312

site_id	CSA12
Number of Residues	2
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
L	ASP60
L	ARG312

site_id	CSA13
Number of Residues	2
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
M	ASP60
M	ARG312

site_id	CSA14
Number of Residues	2
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
N	ASP60
N	ARG312

site_id	CSA15
Number of Residues	2
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
O	ASP60
O	ARG312

site_id	CSA16
Number of Residues	2
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
P	ASP60
P	ARG312

site_id	CSA17
Number of Residues	2
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
Q	ASP60
Q	ARG312

site_id	CSA18
Number of Residues	2
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
R	ASP60
R	ARG312

site_id	CSA19
Number of Residues	2
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
S	ASP60
S	ARG312

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
B	ASP60
B	ARG312

site_id	CSA20
Number of Residues	2
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
T	ASP60
T	ARG312

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
C	ASP60
C	ARG312

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
D	ASP60
D	ARG312

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
E	ASP60
E	ARG312

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
F	ASP60
F	ARG312

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
G	ASP60
G	ARG312

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
H	ASP60
H	ARG312

site_id	CSA9
Number of Residues	2
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
I	ASP60
I	ARG312

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)