3FJU

Ascaris suum carboxypeptidase inhibitor in complex with human carboxypeptidase A1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004181	molecular_function	metallocarboxypeptidase activity
A	0006508	biological_process	proteolysis
A	0008270	molecular_function	zinc ion binding
B	0008191	molecular_function	metalloendopeptidase inhibitor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 999

Chain	Residue
A	HIS69
A	GLU72
A	HIS196
B	LEU67

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 501

Chain	Residue
A	HIS120
A	ASP217
A	ACT519
A	HOH647

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 502

Chain	Residue
A	CAC513
A	ACT518
A	HOH716
A	HIS303

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 503

Chain	Residue
A	HIS307
A	CAC513
A	HOH688
B	HIS54

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 505

Chain	Residue
A	GLU16
A	ASP20
A	HIS132
A	CAC514

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 506

Chain	Residue
A	HIS166
A	CAC511
A	CAC512
A	HOH525

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 507

Chain	Residue
A	HIS31
A	CAC511
A	CAC512
A	ACT517

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 508

Chain	Residue
A	ASP5
A	HOH521
A	HOH522
A	HOH524

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 509

Chain	Residue
A	GLU17
A	CAC514
A	HOH765
A	HOH773

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 510

Chain	Residue
A	SER172
A	HOH573
A	HOH602
A	HOH836
A	HOH970

---

site_id	BC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CAC A 511

Chain	Residue
A	HIS31
A	SER158
A	HIS166
A	ZN506
A	ZN507
A	CAC512
A	ACT517
A	HOH525
A	HOH1014

---

site_id	BC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE CAC A 512

Chain	Residue
A	HIS31
A	GLY152
A	LEU153
A	SER154
A	ALA156
A	SER158
A	HIS166
A	ZN506
A	ZN507
A	CAC511
A	ACT517
A	HOH937

---

site_id	BC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CAC A 513

Chain	Residue
A	THR122
A	ASN123
A	HIS303
A	HIS307
A	ZN502
A	ZN503
A	ACT518
A	HOH719
B	HIS54

---

site_id	BC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CAC A 514

Chain	Residue
A	GLU16
A	GLU17
A	ASP20
A	HIS132
A	ALA134
A	ZN505
A	ZN509
A	HOH726
A	HOH920

---

site_id	BC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ACT A 515

Chain	Residue
A	HIS69
A	ARG127
A	ASN144
A	ARG145
A	TYR248
A	GLU270
B	LEU67

---

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT A 516

Chain	Residue
A	CYS161
A	HOH571
A	HOH578
A	HOH707
A	HOH710
A	HOH977

---

site_id	BC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ACT A 517

Chain	Residue
A	HOH1033
A	PRO30
A	HIS31
A	SER158
A	ZN507
A	CAC511
A	CAC512

---

site_id	BC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ACT A 518

Chain	Residue
A	HIS303
A	ASN306
A	HIS307
A	ZN502
A	CAC513
A	HOH716
A	HOH717

---

site_id	CC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ACT A 519

Chain	Residue
A	TYR12
A	HIS13
A	HIS120
A	GLN216
A	ASP217
A	ZN501
A	HOH647

---

site_id	CC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT A 520

Chain	Residue
A	LYS51
A	HIS186
A	SER232
A	HOH553
A	HOH943
A	HOH993

---

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 504

Chain	Residue
B	GLU37
B	HIS38
B	HOH740
B	HOH873
B	HOH1078

---

Functional Information from PROSITE/UniProt

site_id	PS00132
Number of Residues	23
Details	CARBOXYPEPT_ZN_1 Zinc carboxypeptidases, zinc-binding region 1 signature. PaIwIdtGiHSrEwVTQasgvwF

Chain	Residue	Details
A	PRO60-PHE82

---

site_id	PS00133
Number of Residues	11
Details	CARBOXYPEPT_ZN_2 Zinc carboxypeptidases, zinc-binding region 2 signature. HSYSQLLmYPY

Chain	Residue	Details
A	HIS196-TYR206

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	293
Details	Domain: {"description":"Peptidase M14","evidences":[{"source":"PROSITE-ProRule","id":"PRU01379","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01379","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18566513","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2V77","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01379","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18566513","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2V77","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1cbx

Chain	Residue	Details
A	ARG127
A	GLU270

---

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1cbx

Chain	Residue	Details
A	ARG71
A	GLU270
A	ARG127

---