3FH6

Crystal structure of the resting state maltose transporter from E. coli

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005886	cellular_component	plasma membrane
A	0008643	biological_process	carbohydrate transport
A	0015423	molecular_function	ABC-type maltose transporter activity
A	0015768	biological_process	maltose transport
A	0016020	cellular_component	membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0022857	molecular_function	transmembrane transporter activity
A	0032991	cellular_component	protein-containing complex
A	0034763	biological_process	negative regulation of transmembrane transport
A	0042956	biological_process	maltodextrin transmembrane transport
A	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
A	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
A	0055085	biological_process	transmembrane transport
A	0071702	biological_process	organic substance transport
A	0140297	molecular_function	DNA-binding transcription factor binding
A	0140359	molecular_function	ABC-type transporter activity
A	1902344	biological_process	negative regulation of maltose transport
A	1904981	biological_process	maltose transmembrane transport
A	1990060	cellular_component	maltose transport complex
A	1990154	cellular_component	enzyme IIA-maltose transporter complex
B	0000166	molecular_function	nucleotide binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005886	cellular_component	plasma membrane
B	0008643	biological_process	carbohydrate transport
B	0015423	molecular_function	ABC-type maltose transporter activity
B	0015768	biological_process	maltose transport
B	0016020	cellular_component	membrane
B	0016887	molecular_function	ATP hydrolysis activity
B	0022857	molecular_function	transmembrane transporter activity
B	0032991	cellular_component	protein-containing complex
B	0034763	biological_process	negative regulation of transmembrane transport
B	0042956	biological_process	maltodextrin transmembrane transport
B	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
B	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
B	0055085	biological_process	transmembrane transport
B	0071702	biological_process	organic substance transport
B	0140297	molecular_function	DNA-binding transcription factor binding
B	0140359	molecular_function	ABC-type transporter activity
B	1902344	biological_process	negative regulation of maltose transport
B	1904981	biological_process	maltose transmembrane transport
B	1990060	cellular_component	maltose transport complex
B	1990154	cellular_component	enzyme IIA-maltose transporter complex
C	0000166	molecular_function	nucleotide binding
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005886	cellular_component	plasma membrane
C	0008643	biological_process	carbohydrate transport
C	0015423	molecular_function	ABC-type maltose transporter activity
C	0015768	biological_process	maltose transport
C	0016020	cellular_component	membrane
C	0016887	molecular_function	ATP hydrolysis activity
C	0022857	molecular_function	transmembrane transporter activity
C	0032991	cellular_component	protein-containing complex
C	0034763	biological_process	negative regulation of transmembrane transport
C	0042956	biological_process	maltodextrin transmembrane transport
C	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
C	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
C	0055085	biological_process	transmembrane transport
C	0071702	biological_process	organic substance transport
C	0140297	molecular_function	DNA-binding transcription factor binding
C	0140359	molecular_function	ABC-type transporter activity
C	1902344	biological_process	negative regulation of maltose transport
C	1904981	biological_process	maltose transmembrane transport
C	1990060	cellular_component	maltose transport complex
C	1990154	cellular_component	enzyme IIA-maltose transporter complex
D	0000166	molecular_function	nucleotide binding
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005886	cellular_component	plasma membrane
D	0008643	biological_process	carbohydrate transport
D	0015423	molecular_function	ABC-type maltose transporter activity
D	0015768	biological_process	maltose transport
D	0016020	cellular_component	membrane
D	0016887	molecular_function	ATP hydrolysis activity
D	0022857	molecular_function	transmembrane transporter activity
D	0032991	cellular_component	protein-containing complex
D	0034763	biological_process	negative regulation of transmembrane transport
D	0042956	biological_process	maltodextrin transmembrane transport
D	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
D	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
D	0055085	biological_process	transmembrane transport
D	0071702	biological_process	organic substance transport
D	0140297	molecular_function	DNA-binding transcription factor binding
D	0140359	molecular_function	ABC-type transporter activity
D	1902344	biological_process	negative regulation of maltose transport
D	1904981	biological_process	maltose transmembrane transport
D	1990060	cellular_component	maltose transport complex
D	1990154	cellular_component	enzyme IIA-maltose transporter complex
F	0005515	molecular_function	protein binding
F	0005886	cellular_component	plasma membrane
F	0006974	biological_process	DNA damage response
F	0015423	molecular_function	ABC-type maltose transporter activity
F	0015768	biological_process	maltose transport
F	0016020	cellular_component	membrane
F	0034763	biological_process	negative regulation of transmembrane transport
F	0042956	biological_process	maltodextrin transmembrane transport
F	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
F	0055085	biological_process	transmembrane transport
F	0071702	biological_process	organic substance transport
F	1902344	biological_process	negative regulation of maltose transport
F	1904981	biological_process	maltose transmembrane transport
F	1990060	cellular_component	maltose transport complex
F	1990154	cellular_component	enzyme IIA-maltose transporter complex
G	0005515	molecular_function	protein binding
G	0005886	cellular_component	plasma membrane
G	0015423	molecular_function	ABC-type maltose transporter activity
G	0015768	biological_process	maltose transport
G	0016020	cellular_component	membrane
G	0034763	biological_process	negative regulation of transmembrane transport
G	0042956	biological_process	maltodextrin transmembrane transport
G	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
G	0055085	biological_process	transmembrane transport
G	0071702	biological_process	organic substance transport
G	1902344	biological_process	negative regulation of maltose transport
G	1904981	biological_process	maltose transmembrane transport
G	1990060	cellular_component	maltose transport complex
G	1990154	cellular_component	enzyme IIA-maltose transporter complex
H	0005515	molecular_function	protein binding
H	0005886	cellular_component	plasma membrane
H	0006974	biological_process	DNA damage response
H	0015423	molecular_function	ABC-type maltose transporter activity
H	0015768	biological_process	maltose transport
H	0016020	cellular_component	membrane
H	0034763	biological_process	negative regulation of transmembrane transport
H	0042956	biological_process	maltodextrin transmembrane transport
H	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
H	0055085	biological_process	transmembrane transport
H	0071702	biological_process	organic substance transport
H	1902344	biological_process	negative regulation of maltose transport
H	1904981	biological_process	maltose transmembrane transport
H	1990060	cellular_component	maltose transport complex
H	1990154	cellular_component	enzyme IIA-maltose transporter complex
I	0005515	molecular_function	protein binding
I	0005886	cellular_component	plasma membrane
I	0015423	molecular_function	ABC-type maltose transporter activity
I	0015768	biological_process	maltose transport
I	0016020	cellular_component	membrane
I	0034763	biological_process	negative regulation of transmembrane transport
I	0042956	biological_process	maltodextrin transmembrane transport
I	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
I	0055085	biological_process	transmembrane transport
I	0071702	biological_process	organic substance transport
I	1902344	biological_process	negative regulation of maltose transport
I	1904981	biological_process	maltose transmembrane transport
I	1990060	cellular_component	maltose transport complex
I	1990154	cellular_component	enzyme IIA-maltose transporter complex

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQRQRVAIGRTL

Chain	Residue	Details
A	LEU134-LEU148

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01709

Chain	Residue	Details
A	GLY36
B	GLY36
C	GLY36
D	GLY36
I	MET1-LEU18
I	SER103-LYS123
I	LEU172-ARG204
I	ALA281-GLY296

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site_id	SWS_FT_FI2
Number of Residues	240
Details	TRANSMEM: Helical => ECO:0000305

Chain	Residue	Details
G	LEU19-LEU39
I	ILE151-ALA171
I	LEU205-ALA225
I	TRP260-LEU280
H	LEU426-PRO452
H	PHE484-ASN505
G	LEU82-LEU102
G	GLY124-PHE144
G	ILE151-ALA171
G	LEU205-ALA225
G	TRP260-LEU280
I	LEU19-LEU39
I	LEU82-LEU102
I	GLY124-PHE144

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site_id	SWS_FT_FI3
Number of Residues	158
Details	TOPO_DOM: Periplasmic => ECO:0000305

Chain	Residue	Details
G	ARG40-VAL81
G	ASP145-TYR150
G	ALA226-LEU259
I	ARG40-VAL81
I	ASP145-TYR150
I	ALA226-LEU259
H	LYS393-PRO425
H	LEU506-ASP514

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