3FEY
Crystal structure of the CBC-importin alpha complex.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000184 | biological_process | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| A | 0000245 | biological_process | spliceosomal complex assembly |
| A | 0000339 | molecular_function | RNA cap binding |
| A | 0000340 | molecular_function | RNA 7-methylguanosine cap binding |
| A | 0000380 | biological_process | alternative mRNA splicing, via spliceosome |
| A | 0000398 | biological_process | mRNA splicing, via spliceosome |
| A | 0002191 | biological_process | cap-dependent translational initiation |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003729 | molecular_function | mRNA binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005846 | cellular_component | nuclear cap binding complex |
| A | 0006370 | biological_process | 7-methylguanosine mRNA capping |
| A | 0006401 | biological_process | RNA catabolic process |
| A | 0006406 | biological_process | mRNA export from nucleus |
| A | 0006408 | biological_process | snRNA export from nucleus |
| A | 0006446 | biological_process | regulation of translational initiation |
| A | 0008334 | biological_process | histone mRNA metabolic process |
| A | 0008380 | biological_process | RNA splicing |
| A | 0016070 | biological_process | RNA metabolic process |
| A | 0016071 | biological_process | mRNA metabolic process |
| A | 0030307 | biological_process | positive regulation of cell growth |
| A | 0031053 | biological_process | primary miRNA processing |
| A | 0031124 | biological_process | mRNA 3'-end processing |
| A | 0031442 | biological_process | positive regulation of mRNA 3'-end processing |
| A | 0032968 | biological_process | positive regulation of transcription elongation by RNA polymerase II |
| A | 0034518 | cellular_component | RNA cap binding complex |
| A | 0035194 | biological_process | regulatory ncRNA-mediated post-transcriptional gene silencing |
| A | 0035195 | biological_process | miRNA-mediated post-transcriptional gene silencing |
| A | 0042789 | biological_process | mRNA transcription by RNA polymerase II |
| A | 0048026 | biological_process | positive regulation of mRNA splicing, via spliceosome |
| A | 0050684 | biological_process | regulation of mRNA processing |
| A | 0051607 | biological_process | defense response to virus |
| A | 0060090 | molecular_function | molecular adaptor activity |
| A | 1990904 | cellular_component | ribonucleoprotein complex |
| B | 0000184 | biological_process | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| B | 0000339 | molecular_function | RNA cap binding |
| B | 0000340 | molecular_function | RNA 7-methylguanosine cap binding |
| B | 0000380 | biological_process | alternative mRNA splicing, via spliceosome |
| B | 0000398 | biological_process | mRNA splicing, via spliceosome |
| B | 0002191 | biological_process | cap-dependent translational initiation |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003729 | molecular_function | mRNA binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005846 | cellular_component | nuclear cap binding complex |
| B | 0006406 | biological_process | mRNA export from nucleus |
| B | 0006408 | biological_process | snRNA export from nucleus |
| B | 0006446 | biological_process | regulation of translational initiation |
| B | 0008334 | biological_process | histone mRNA metabolic process |
| B | 0008380 | biological_process | RNA splicing |
| B | 0016071 | biological_process | mRNA metabolic process |
| B | 0017069 | molecular_function | snRNA binding |
| B | 0031053 | biological_process | primary miRNA processing |
| B | 0031124 | biological_process | mRNA 3'-end processing |
| B | 0031442 | biological_process | positive regulation of mRNA 3'-end processing |
| B | 0032968 | biological_process | positive regulation of transcription elongation by RNA polymerase II |
| B | 0034518 | cellular_component | RNA cap binding complex |
| B | 0035194 | biological_process | regulatory ncRNA-mediated post-transcriptional gene silencing |
| B | 0035195 | biological_process | miRNA-mediated post-transcriptional gene silencing |
| B | 0042789 | biological_process | mRNA transcription by RNA polymerase II |
| B | 0045292 | biological_process | mRNA cis splicing, via spliceosome |
| B | 0046833 | biological_process | positive regulation of RNA export from nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006606 | biological_process | protein import into nucleus |
| C | 0061608 | molecular_function | nuclear import signal receptor activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 212 |
| Details | Domain: {"description":"MIF4G"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 17 |
| Details | Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by RPS6KB1","evidences":[{"source":"PubMed","id":"10973943","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by RPS6KB1","evidences":[{"source":"PubMed","id":"10973943","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39603239","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by RPS6KB1","evidences":[{"source":"PubMed","id":"10973943","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12374755","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12434151","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 40 |
| Details | Repeat: {"description":"ARM 1; truncated"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"ARM 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"ARM 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 36 |
| Details | Repeat: {"description":"ARM 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"ARM 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"ARM 7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"ARM 8"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 46 |
| Details | Repeat: {"description":"ARM 9"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"ARM 10; atypical"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 88 |
| Details | Region: {"description":"NLS binding site (minor)","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
