3FBD

Crystal structure of the nuclease domain of COLE7(D493Q mutant) in complex with an 18-BP duplex DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004519	molecular_function	endonuclease activity
A	0005102	molecular_function	signaling receptor binding
A	0009617	biological_process	response to bacterium
A	0019835	biological_process	cytolysis
D	0004519	molecular_function	endonuclease activity
D	0005102	molecular_function	signaling receptor binding
D	0009617	biological_process	response to bacterium
D	0019835	biological_process	cytolysis

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	102
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	26
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	5
Details	M-CSA 838

Chain	Residue	Details
A	ARG447	electrostatic stabiliser, proton acceptor, proton donor, proton relay
A	HIS544	metal ligand
A	HIS545	proton acceptor, proton donor
A	HIS569	metal ligand
A	HIS573	metal ligand

---

site_id	MCSA2
Number of Residues	5
Details	M-CSA 838

Chain	Residue	Details
D	ARG447	electrostatic stabiliser, proton acceptor, proton donor, proton relay
D	HIS544	metal ligand
D	HIS545	proton acceptor, proton donor
D	HIS569	metal ligand
D	HIS573	metal ligand

---