3FAV

Structure of the CFP10-ESAT6 complex from Mycobacterium tuberculosis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005886	cellular_component	plasma membrane
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0044165	cellular_component	host cell endoplasmic reticulum
A	0044228	cellular_component	host cell surface
A	0044315	biological_process	protein secretion by the type VII secretion system
A	0046812	molecular_function	host cell surface binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0009274	cellular_component	peptidoglycan-based cell wall
B	0020002	cellular_component	host cell plasma membrane
B	0030430	cellular_component	host cell cytoplasm
B	0042803	molecular_function	protein homodimerization activity
B	0044165	cellular_component	host cell endoplasmic reticulum
B	0044228	cellular_component	host cell surface
B	0044315	biological_process	protein secretion by the type VII secretion system
B	0046812	molecular_function	host cell surface binding
B	0052027	biological_process	symbiont-mediated perturbation of host signal transduction pathway
B	0052085	biological_process	symbiont-mediated suppression of host T-cell mediated immune response
B	0052170	biological_process	symbiont-mediated suppression of host innate immune response
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005886	cellular_component	plasma membrane
C	0009274	cellular_component	peptidoglycan-based cell wall
C	0044165	cellular_component	host cell endoplasmic reticulum
C	0044228	cellular_component	host cell surface
C	0044315	biological_process	protein secretion by the type VII secretion system
C	0046812	molecular_function	host cell surface binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0009274	cellular_component	peptidoglycan-based cell wall
D	0020002	cellular_component	host cell plasma membrane
D	0030430	cellular_component	host cell cytoplasm
D	0042803	molecular_function	protein homodimerization activity
D	0044165	cellular_component	host cell endoplasmic reticulum
D	0044228	cellular_component	host cell surface
D	0044315	biological_process	protein secretion by the type VII secretion system
D	0046812	molecular_function	host cell surface binding
D	0052027	biological_process	symbiont-mediated perturbation of host signal transduction pathway
D	0052085	biological_process	symbiont-mediated suppression of host T-cell mediated immune response
D	0052170	biological_process	symbiont-mediated suppression of host innate immune response

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 101

Chain	Residue
A	GLU14
A	ASN17
A	HOH167
B	LYS38
B	HOH132

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site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN A 102

Chain	Residue
A	ASP24
A	HOH303

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site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN B 1

Chain	Residue
B	HOH308
B	HIS26
B	ASP30

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site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 96

Chain	Residue
B	GLU31
B	GLU31
B	IMD97
B	IMD97

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE IMD B 97

Chain	Residue
A	ARG20
A	HOH302
B	LEU28
B	GLU31
B	GLU31
B	ZN96
B	ZN96

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 101

Chain	Residue
B	GLU49
C	GLU3
C	ASP7
C	HOH306

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 102

Chain	Residue
C	ASP30
C	HOH197
C	HOH288
D	ASP30

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN D 96

Chain	Residue
C	GLU33
C	HOH201
D	HIS26

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	37
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16048998","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	66
Details	Coiled coil: {"evidences":[{"source":"PubMed","id":"16048998","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"21969609","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	64
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"25645924","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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