3FAS
X-ray structure of iGluR4 flip ligand-binding core (S1S2) in complex with (S)-glutamate at 1.40A resolution
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE GLU A 270 |
| Chain | Residue |
| A | TYR59 |
| A | TYR218 |
| A | HOH275 |
| A | HOH277 |
| A | HOH563 |
| A | PRO87 |
| A | LEU88 |
| A | THR89 |
| A | ARG94 |
| A | GLY139 |
| A | SER140 |
| A | THR141 |
| A | GLU191 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE GLU B 271 |
| Chain | Residue |
| B | TYR59 |
| B | PRO87 |
| B | LEU88 |
| B | THR89 |
| B | ARG94 |
| B | GLY139 |
| B | SER140 |
| B | THR141 |
| B | GLU191 |
| B | HOH267 |
| B | HOH286 |
| B | HOH314 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 261 |
| Chain | Residue |
| A | SER138 |
| A | LYS142 |
| A | ARG146 |
| A | HOH329 |
| A | HOH395 |
| A | HOH459 |
| A | HOH474 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 261 |
| Chain | Residue |
| B | ASP137 |
| B | SER138 |
| B | LYS142 |
| B | ARG146 |
| B | HOH461 |
| B | HOH576 |
| B | HOH659 |
| B | HOH1206 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 262 |
| Chain | Residue |
| B | HIS44 |
| B | LYS238 |
| B | HOH1111 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 262 |
| Chain | Residue |
| A | GLY1 |
| A | ARG2 |
| A | HOH524 |
| A | HOH584 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 263 |
| Chain | Residue |
| B | GLY1 |
| B | ARG2 |
| B | HOH336 |
| B | HOH663 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 263 |
| Chain | Residue |
| A | GLU95 |
| A | ASP99 |
| A | PHE100 |
| A | ARG229 |
| A | HOH510 |
| A | HOH683 |
| A | HOH804 |
| B | LYS102 |
| B | ASN233 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 B 264 |
| Chain | Residue |
| A | LYS102 |
| A | ASN233 |
| A | HOH683 |
| B | GLU95 |
| B | ASP99 |
| B | PHE100 |
| B | ARG229 |
| B | HOH472 |
| B | HOH597 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 265 |
| Chain | Residue |
| B | HIS21 |
| B | GLU22 |
| B | LYS29 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 300 |
| Chain | Residue |
| A | ARG146 |
| A | TRP157 |
| A | ARG161 |
| A | HOH380 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 301 |
| Chain | Residue |
| A | ASN212 |
| A | ASP214 |
| A | SER215 |
| A | HOH364 |
| A | HOH466 |
| B | ASP246 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 302 |
| Chain | Residue |
| A | ASP246 |
| B | ASN212 |
| B | LEU213 |
| B | ASP214 |
| B | SER215 |
| B | HOH374 |
| B | HOH474 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 304 |
| Chain | Residue |
| A | TYR17 |
| A | HIS21 |
| A | GLU22 |
| A | LYS29 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 306 |
| Chain | Residue |
| B | ARG146 |
| B | TRP157 |
| B | ARG161 |
| B | HOH471 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 308 |
| Chain | Residue |
| B | LYS29 |
| B | LYS50 |
| B | HOH714 |
| B | GLU25 |
| B | GLY26 |
| site_id | BC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 310 |
| Chain | Residue |
| B | VAL97 |
| B | GLY116 |
| B | PRO118 |
| B | HOH284 |
| B | HOH399 |
| B | HOH404 |
| B | HOH425 |
| site_id | BC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 312 |
| Chain | Residue |
| B | GLU40 |
| B | LYS43 |
| B | HIS44 |
| B | LEU239 |
| B | ALA242 |
| B | VAL244 |
| B | HOH596 |
| site_id | CC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 313 |
| Chain | Residue |
| A | GLU123 |
| A | ILE150 |
| A | VAL152 |
| A | HOH434 |
| A | HOH655 |
| A | HOH815 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19022251","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19102704","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20107073","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3EPE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FAS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KEI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
