3F9O

Crystal Structure of the Di-Zinc Carbapenemase CphA from Aeromonas Hydrophila

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008270	molecular_function	zinc ion binding
A	0008800	molecular_function	beta-lactamase activity
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0042597	cellular_component	periplasmic space
A	0046677	biological_process	response to antibiotic
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 1

Chain	Residue
A	HOH107
A	HIS118
A	ASP120
A	HIS196
A	HIS263
A	ZN308
A	ZN309
A	HOH334
A	HOH474

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 2

Chain	Residue
A	HIS176
A	ASP177
A	HOH465

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 3

Chain	Residue
A	ALA237
A	ASP238
A	VAL239
A	LYS240

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 4

Chain	Residue
A	SER104
A	LYS106
A	HOH348
A	HOH466

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CO3 A 5

Chain	Residue
A	LEU249
A	LYS250
A	LYS253
A	LEU254
A	ILE256
A	HOH365
A	HOH421

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CO3 A 6

Chain	Residue
A	ARG158
A	ASP166
A	HOH449

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 7

Chain	Residue
A	HOH19
A	ASN116
A	ASN220
A	CYS221
A	ILE222

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 9

Chain	Residue
A	GLN47
A	HOH393

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 10

Chain	Residue
A	CL11
A	ZN310

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 11

Chain	Residue
A	CL10
A	HIS289
A	LEU293
A	ZN310

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 12

Chain	Residue
A	HIS289
A	GLY290
A	ZN310

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 308

Chain	Residue
A	SO41
A	ASP120
A	CYS221
A	HIS263

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 309

Chain	Residue
A	SO41
A	HIS118
A	HIS196
A	HOH474

---

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 310

Chain	Residue
A	CL10
A	CL11
A	CL12
A	HIS289

---

Functional Information from PROSITE/UniProt

site_id	PS00743
Number of Residues	20
Details	BETA_LACTAMASE_B_1 Beta-lactamases class B signature 1. InTNyHTDraGGnaywksi.G

Chain	Residue	Details
A	ILE113-GLY133

---

site_id	PS00744
Number of Residues	13
Details	BETA_LACTAMASE_B_2 Beta-lactamases class B signature 2. PdeqVLyGnCILK

Chain	Residue	Details
A	PRO209-LYS224

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:15588826, ECO:0000269|PubMed:17307979, ECO:0000269|PubMed:18563261, ECO:0000269|PubMed:19651913, ECO:0000269|PubMed:20527888

Chain	Residue	Details
A	ASP120
A	CYS221
A	HIS263

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:15588826

Chain	Residue	Details
A	THR157

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:15588826, ECO:0000269|PubMed:18563261, ECO:0000269|PubMed:20527888

Chain	Residue	Details
A	HIS196

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:15588826, ECO:0000269|PubMed:17307979, ECO:0000269|PubMed:20527888

Chain	Residue	Details
A	LYS224

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:15588826, ECO:0000269|PubMed:17307979, ECO:0000269|PubMed:18563261

Chain	Residue	Details
A	ASN233

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 2bmi

Chain	Residue	Details
A	ASP120
A	ASN233

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 2bmi

Chain	Residue	Details
A	ASP120

---