3F6Q

Crystal structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 401

Chain	Residue
A	HOH275

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 403

Chain	Residue
A	THR167
A	IOD415

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IOD A 404

Chain	Residue
A	HOH214
A	HOH219
A	HOH302

---

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 405

Chain	Residue
A	LYS85

---

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 406

Chain	Residue
A	GLN114

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IOD A 407

Chain	Residue
A	ASP81
A	HOH329
A	SER47

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 408

Chain	Residue
A	GLN7
A	HOH402

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 409

Chain	Residue
A	GLN84
A	ASN122

---

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 410

Chain	Residue
A	TRP110

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE IOD A 411

Chain	Residue
A	GLN7
A	GLU10
A	ASN12
B	GLU47

---

site_id	BC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 412

Chain	Residue
B	HOH200

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE IOD A 413

Chain	Residue
A	ARG43
A	LEU73
A	PO4450
B	PHE67

---

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 414

Chain	Residue
A	ASN61
A	HOH326

---

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 415

Chain	Residue
A	PHE168
A	IOD403

---

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IOD A 416

Chain	Residue
A	ARG161
A	HOH340
A	HOH435

---

site_id	BC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 417

Chain	Residue
A	PRO143
B	GLU60

---

site_id	BC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 418

Chain	Residue
A	LYS165
A	HOH289

---

site_id	BC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 A 450

Chain	Residue
A	ARG43
A	SER76
A	HIS77
A	HOH187
A	IOD413
B	GLN40
B	ARG56
B	TYR58
B	HOH107

---

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 301

Chain	Residue
B	CYS38
B	CYS41
B	CYS59
B	ASP62

---

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 302

Chain	Residue
B	CYS10
B	CYS13
B	HIS32
B	CYS35

---

Functional Information from PROSITE/UniProt

site_id	PS00478
Number of Residues	36
Details	LIM_DOMAIN_1 LIM zinc-binding domain signature. CerCkggfapaekivnsngel....YHeqCfvCaqCfqqF

Chain	Residue	Details
B	CYS10-PHE45

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	28
Details	Repeat: {"description":"ANK 1","evidences":[{"source":"PubMed","id":"19074270","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	32
Details	Repeat: {"description":"ANK 2","evidences":[{"source":"PubMed","id":"19074270","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	32
Details	Repeat: {"description":"ANK 3","evidences":[{"source":"PubMed","id":"19074270","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	32
Details	Repeat: {"description":"ANK 4","evidences":[{"source":"PubMed","id":"19074270","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	106
Details	Region: {"description":"Interaction with LIMS1","evidences":[{"source":"PubMed","id":"12167643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	52
Details	Domain: {"description":"LIM zinc-binding 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00125","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---