3F5P
Complex Structure of Insulin-like Growth Factor Receptor and 3-Cyanoquinoline Inhibitor
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004672 | molecular_function | protein kinase activity |
A | 0004713 | molecular_function | protein tyrosine kinase activity |
A | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0006468 | biological_process | protein phosphorylation |
A | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
A | 0016020 | cellular_component | membrane |
B | 0004672 | molecular_function | protein kinase activity |
B | 0004713 | molecular_function | protein tyrosine kinase activity |
B | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0006468 | biological_process | protein phosphorylation |
B | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
B | 0016020 | cellular_component | membrane |
C | 0004672 | molecular_function | protein kinase activity |
C | 0004713 | molecular_function | protein tyrosine kinase activity |
C | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
C | 0005524 | molecular_function | ATP binding |
C | 0006468 | biological_process | protein phosphorylation |
C | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
C | 0016020 | cellular_component | membrane |
D | 0004672 | molecular_function | protein kinase activity |
D | 0004713 | molecular_function | protein tyrosine kinase activity |
D | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
D | 0005524 | molecular_function | ATP binding |
D | 0006468 | biological_process | protein phosphorylation |
D | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
D | 0016020 | cellular_component | membrane |
E | 0004672 | molecular_function | protein kinase activity |
E | 0004713 | molecular_function | protein tyrosine kinase activity |
E | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
E | 0005524 | molecular_function | ATP binding |
E | 0006468 | biological_process | protein phosphorylation |
E | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
E | 0016020 | cellular_component | membrane |
F | 0004672 | molecular_function | protein kinase activity |
F | 0004713 | molecular_function | protein tyrosine kinase activity |
F | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
F | 0005524 | molecular_function | ATP binding |
F | 0006468 | biological_process | protein phosphorylation |
F | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
F | 0016020 | cellular_component | membrane |
G | 0004672 | molecular_function | protein kinase activity |
G | 0004713 | molecular_function | protein tyrosine kinase activity |
G | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
G | 0005524 | molecular_function | ATP binding |
G | 0006468 | biological_process | protein phosphorylation |
G | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
G | 0016020 | cellular_component | membrane |
H | 0004672 | molecular_function | protein kinase activity |
H | 0004713 | molecular_function | protein tyrosine kinase activity |
H | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
H | 0005524 | molecular_function | ATP binding |
H | 0006468 | biological_process | protein phosphorylation |
H | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
H | 0016020 | cellular_component | membrane |
I | 0004672 | molecular_function | protein kinase activity |
I | 0004713 | molecular_function | protein tyrosine kinase activity |
I | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
I | 0005524 | molecular_function | ATP binding |
I | 0006468 | biological_process | protein phosphorylation |
I | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
I | 0016020 | cellular_component | membrane |
J | 0004672 | molecular_function | protein kinase activity |
J | 0004713 | molecular_function | protein tyrosine kinase activity |
J | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
J | 0005524 | molecular_function | ATP binding |
J | 0006468 | biological_process | protein phosphorylation |
J | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
J | 0016020 | cellular_component | membrane |
K | 0004672 | molecular_function | protein kinase activity |
K | 0004713 | molecular_function | protein tyrosine kinase activity |
K | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
K | 0005524 | molecular_function | ATP binding |
K | 0006468 | biological_process | protein phosphorylation |
K | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
K | 0016020 | cellular_component | membrane |
L | 0004672 | molecular_function | protein kinase activity |
L | 0004713 | molecular_function | protein tyrosine kinase activity |
L | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
L | 0005524 | molecular_function | ATP binding |
L | 0006468 | biological_process | protein phosphorylation |
L | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
L | 0016020 | cellular_component | membrane |
M | 0004672 | molecular_function | protein kinase activity |
M | 0004713 | molecular_function | protein tyrosine kinase activity |
M | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
M | 0005524 | molecular_function | ATP binding |
M | 0006468 | biological_process | protein phosphorylation |
M | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
M | 0016020 | cellular_component | membrane |
R | 0004672 | molecular_function | protein kinase activity |
R | 0004713 | molecular_function | protein tyrosine kinase activity |
R | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
R | 0005524 | molecular_function | ATP binding |
R | 0006468 | biological_process | protein phosphorylation |
R | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
R | 0016020 | cellular_component | membrane |
S | 0004672 | molecular_function | protein kinase activity |
S | 0004713 | molecular_function | protein tyrosine kinase activity |
S | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
S | 0005524 | molecular_function | ATP binding |
S | 0006468 | biological_process | protein phosphorylation |
S | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
S | 0016020 | cellular_component | membrane |
T | 0004672 | molecular_function | protein kinase activity |
T | 0004713 | molecular_function | protein tyrosine kinase activity |
T | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
T | 0005524 | molecular_function | ATP binding |
T | 0006468 | biological_process | protein phosphorylation |
T | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
T | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE 741 A 1 |
Chain | Residue |
A | LEU1005 |
A | GLU1080 |
A | MET1082 |
A | THR1083 |
A | MET1142 |
A | SER1009 |
A | ALA1031 |
A | LYS1033 |
A | PHE1047 |
A | GLU1050 |
A | VAL1063 |
A | VAL1077 |
A | MET1079 |
site_id | AC2 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE 741 B 2 |
Chain | Residue |
B | ALA1031 |
B | LYS1033 |
B | PHE1047 |
B | GLU1050 |
B | VAL1063 |
B | VAL1077 |
B | MET1079 |
B | GLU1080 |
B | LEU1081 |
B | MET1082 |
B | THR1083 |
B | GLY1085 |
site_id | AC3 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE 741 C 3 |
Chain | Residue |
C | LEU1005 |
C | SER1009 |
C | ALA1031 |
C | LYS1033 |
C | PHE1047 |
C | GLU1050 |
C | MET1054 |
C | VAL1077 |
C | MET1079 |
C | GLU1080 |
C | MET1082 |
C | THR1083 |
C | MET1142 |
site_id | AC4 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE 741 D 4 |
Chain | Residue |
D | LEU1005 |
D | SER1009 |
D | ALA1031 |
D | LYS1033 |
D | PHE1047 |
D | GLU1050 |
D | MET1054 |
D | VAL1063 |
D | VAL1077 |
D | MET1079 |
D | GLU1080 |
D | LEU1081 |
D | MET1082 |
D | THR1083 |
D | MET1142 |
site_id | AC5 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE 741 E 5 |
Chain | Residue |
E | LEU1005 |
E | SER1009 |
E | ALA1031 |
E | LYS1033 |
E | PHE1047 |
E | GLU1050 |
E | MET1054 |
E | VAL1077 |
E | MET1079 |
E | GLU1080 |
E | LEU1081 |
E | MET1082 |
E | THR1083 |
E | ARG1084 |
E | GLY1085 |
E | MET1142 |
site_id | AC6 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE 741 F 6 |
Chain | Residue |
F | LEU1005 |
F | SER1009 |
F | VAL1013 |
F | ALA1031 |
F | LYS1033 |
F | GLU1050 |
F | MET1054 |
F | VAL1077 |
F | MET1079 |
F | GLU1080 |
F | LEU1081 |
F | MET1082 |
F | THR1083 |
F | MET1142 |
site_id | AC7 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE 741 G 7 |
Chain | Residue |
G | LEU1005 |
G | SER1009 |
G | VAL1013 |
G | LYS1033 |
G | PHE1047 |
G | GLU1050 |
G | VAL1063 |
G | VAL1077 |
G | MET1079 |
G | GLU1080 |
G | LEU1081 |
G | MET1082 |
G | THR1083 |
G | GLY1085 |
G | MET1142 |
site_id | AC8 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE 741 H 8 |
Chain | Residue |
H | SER1009 |
H | VAL1013 |
H | ALA1031 |
H | LYS1033 |
H | GLU1050 |
H | MET1054 |
H | VAL1077 |
H | MET1079 |
H | GLU1080 |
H | MET1082 |
H | THR1083 |
H | MET1142 |
H | LEU1005 |
site_id | AC9 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE 741 I 9 |
Chain | Residue |
I | LEU1005 |
I | SER1009 |
I | LYS1033 |
I | PHE1047 |
I | GLU1050 |
I | VAL1077 |
I | MET1079 |
I | GLU1080 |
I | MET1082 |
I | THR1083 |
I | MET1142 |
site_id | BC1 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE 741 J 10 |
Chain | Residue |
J | HOH111 |
J | LEU1005 |
J | SER1009 |
J | ALA1031 |
J | LYS1033 |
J | PHE1047 |
J | GLU1050 |
J | MET1054 |
J | VAL1077 |
J | MET1079 |
J | GLU1080 |
J | LEU1081 |
J | MET1082 |
J | THR1083 |
J | MET1142 |
site_id | BC2 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE 741 K 11 |
Chain | Residue |
K | LEU1005 |
K | ALA1031 |
K | LYS1033 |
K | PHE1047 |
K | GLU1050 |
K | MET1054 |
K | VAL1077 |
K | MET1079 |
K | GLU1080 |
K | MET1082 |
K | THR1083 |
K | MET1142 |
site_id | BC3 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE 741 M 12 |
Chain | Residue |
M | LEU1005 |
M | SER1009 |
M | VAL1013 |
M | ALA1031 |
M | LYS1033 |
M | PHE1047 |
M | GLU1050 |
M | VAL1077 |
M | MET1079 |
M | GLU1080 |
M | LEU1081 |
M | MET1082 |
M | THR1083 |
M | MET1142 |
site_id | BC4 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE 741 L 13 |
Chain | Residue |
L | HOH156 |
L | LEU1005 |
L | SER1009 |
L | VAL1013 |
L | ALA1031 |
L | LYS1033 |
L | PHE1047 |
L | MET1054 |
L | VAL1077 |
L | MET1079 |
L | GLU1080 |
L | LEU1081 |
L | MET1082 |
L | THR1083 |
L | MET1142 |
site_id | BC5 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE 741 R 14 |
Chain | Residue |
R | LEU1005 |
R | SER1009 |
R | VAL1013 |
R | LYS1033 |
R | PHE1047 |
R | GLU1050 |
R | VAL1077 |
R | MET1079 |
R | GLU1080 |
R | MET1082 |
R | THR1083 |
R | MET1142 |
site_id | BC6 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE 741 S 15 |
Chain | Residue |
S | LEU1005 |
S | SER1009 |
S | VAL1013 |
S | ALA1031 |
S | LYS1033 |
S | PHE1047 |
S | GLU1050 |
S | MET1054 |
S | VAL1077 |
S | MET1079 |
S | GLU1080 |
S | LEU1081 |
S | MET1082 |
S | THR1083 |
S | MET1142 |
site_id | BC7 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE 741 T 16 |
Chain | Residue |
T | LEU1005 |
T | ALA1031 |
T | LYS1033 |
T | MET1054 |
T | VAL1063 |
T | VAL1077 |
T | MET1079 |
T | GLU1080 |
T | MET1082 |
T | THR1083 |
T | MET1142 |
Functional Information from PROSITE/UniProt
site_id | PS00107 |
Number of Residues | 29 |
Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGQGSFGMVYeGvakgvvkdepetr.....VAIK |
Chain | Residue | Details |
A | LEU1005-LYS1033 |
site_id | PS00109 |
Number of Residues | 13 |
Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDLAARNCMV |
Chain | Residue | Details |
A | PHE1131-VAL1143 |
site_id | PS00239 |
Number of Residues | 9 |
Details | RECEPTOR_TYR_KIN_II Receptor tyrosine kinase class II signature. DIYetdYYR |
Chain | Residue | Details |
A | ASP1159-ARG1167 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 16 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 |
Chain | Residue | Details |
A | ASP1135 | |
B | ASP1135 | |
C | ASP1135 | |
D | ASP1135 | |
E | ASP1135 | |
F | ASP1135 | |
G | ASP1135 | |
H | ASP1135 | |
I | ASP1135 | |
J | ASP1135 | |
K | ASP1135 | |
M | ASP1135 | |
L | ASP1135 | |
R | ASP1135 | |
S | ASP1135 | |
T | ASP1135 |
site_id | SWS_FT_FI2 |
Number of Residues | 16 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
Chain | Residue | Details |
A | LEU1005 | |
B | LEU1005 | |
C | LEU1005 | |
D | LEU1005 | |
E | LEU1005 | |
F | LEU1005 | |
G | LEU1005 | |
H | LEU1005 | |
I | LEU1005 | |
J | LEU1005 | |
K | LEU1005 | |
M | LEU1005 | |
L | LEU1005 | |
R | LEU1005 | |
S | LEU1005 | |
T | LEU1005 |
site_id | SWS_FT_FI3 |
Number of Residues | 16 |
Details | BINDING: |
Chain | Residue | Details |
A | LYS1033 | |
B | LYS1033 | |
C | LYS1033 | |
D | LYS1033 | |
E | LYS1033 | |
F | LYS1033 | |
G | LYS1033 | |
H | LYS1033 | |
I | LYS1033 | |
J | LYS1033 | |
K | LYS1033 | |
M | LYS1033 | |
L | LYS1033 | |
R | LYS1033 | |
S | LYS1033 | |
T | LYS1033 |
site_id | SWS_FT_FI4 |
Number of Residues | 48 |
Details | MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:11694888, ECO:0000269|PubMed:18501599, ECO:0000269|PubMed:19041240 |
Chain | Residue | Details |
A | PTR1161 | |
A | PTR1165 | |
A | PTR1166 | |
B | PTR1161 | |
B | PTR1165 | |
B | PTR1166 | |
C | PTR1161 | |
C | PTR1165 | |
C | PTR1166 | |
D | PTR1161 | |
D | PTR1165 | |
D | PTR1166 | |
E | PTR1161 | |
E | PTR1165 | |
E | PTR1166 | |
F | PTR1161 | |
F | PTR1165 | |
F | PTR1166 | |
G | PTR1161 | |
G | PTR1165 | |
G | PTR1166 | |
H | PTR1161 | |
H | PTR1165 | |
H | PTR1166 | |
I | PTR1161 | |
I | PTR1165 | |
I | PTR1166 | |
J | PTR1161 | |
J | PTR1165 | |
J | PTR1166 | |
K | PTR1161 | |
K | PTR1165 | |
K | PTR1166 | |
M | PTR1161 | |
M | PTR1165 | |
M | PTR1166 | |
L | PTR1161 | |
L | PTR1165 | |
L | PTR1166 | |
R | PTR1161 | |
R | PTR1165 | |
R | PTR1166 | |
S | PTR1161 | |
S | PTR1165 | |
S | PTR1166 | |
T | PTR1161 | |
T | PTR1165 | |
T | PTR1166 |
site_id | SWS_FT_FI5 |
Number of Residues | 16 |
Details | MOD_RES: Phosphoserine; by GSK3-beta => ECO:0000250|UniProtKB:Q60751 |
Chain | Residue | Details |
A | SER1278 | |
B | SER1278 | |
C | SER1278 | |
D | SER1278 | |
E | SER1278 | |
F | SER1278 | |
G | SER1278 | |
H | SER1278 | |
I | SER1278 | |
J | SER1278 | |
K | SER1278 | |
M | SER1278 | |
L | SER1278 | |
R | SER1278 | |
S | SER1278 | |
T | SER1278 |
site_id | SWS_FT_FI6 |
Number of Residues | 16 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q60751 |
Chain | Residue | Details |
A | SER1282 | |
B | SER1282 | |
C | SER1282 | |
D | SER1282 | |
E | SER1282 | |
F | SER1282 | |
G | SER1282 | |
H | SER1282 | |
I | SER1282 | |
J | SER1282 | |
K | SER1282 | |
M | SER1282 | |
L | SER1282 | |
R | SER1282 | |
S | SER1282 | |
T | SER1282 |
site_id | SWS_FT_FI7 |
Number of Residues | 48 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:21994939 |
Chain | Residue | Details |
A | LYS1168 | |
A | LYS1171 | |
B | LYS1168 | |
B | LYS1171 | |
C | LYS1168 | |
C | LYS1171 | |
D | LYS1168 | |
D | LYS1171 | |
E | LYS1168 | |
E | LYS1171 | |
F | LYS1168 | |
F | LYS1171 | |
G | LYS1168 | |
G | LYS1171 | |
H | LYS1168 | |
H | LYS1171 | |
I | LYS1171 | |
J | LYS1168 | |
J | LYS1171 | |
K | LYS1168 | |
K | LYS1171 | |
M | LYS1168 | |
M | LYS1171 | |
L | LYS1168 | |
L | LYS1171 | |
R | LYS1168 | |
R | LYS1171 | |
S | LYS1168 | |
S | LYS1171 | |
T | LYS1168 | |
T | LYS1171 | |
I | LYS1168 |