Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3F5P

Complex Structure of Insulin-like Growth Factor Receptor and 3-Cyanoquinoline Inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
A	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
A	0016020	cellular_component	membrane
B	0004672	molecular_function	protein kinase activity
B	0004713	molecular_function	protein tyrosine kinase activity
B	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
B	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
B	0016020	cellular_component	membrane
C	0004672	molecular_function	protein kinase activity
C	0004713	molecular_function	protein tyrosine kinase activity
C	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
C	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
C	0016020	cellular_component	membrane
D	0004672	molecular_function	protein kinase activity
D	0004713	molecular_function	protein tyrosine kinase activity
D	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation
D	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
D	0016020	cellular_component	membrane
E	0004672	molecular_function	protein kinase activity
E	0004713	molecular_function	protein tyrosine kinase activity
E	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
E	0005524	molecular_function	ATP binding
E	0006468	biological_process	protein phosphorylation
E	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
E	0016020	cellular_component	membrane
F	0004672	molecular_function	protein kinase activity
F	0004713	molecular_function	protein tyrosine kinase activity
F	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
F	0005524	molecular_function	ATP binding
F	0006468	biological_process	protein phosphorylation
F	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
F	0016020	cellular_component	membrane
G	0004672	molecular_function	protein kinase activity
G	0004713	molecular_function	protein tyrosine kinase activity
G	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
G	0005524	molecular_function	ATP binding
G	0006468	biological_process	protein phosphorylation
G	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
G	0016020	cellular_component	membrane
H	0004672	molecular_function	protein kinase activity
H	0004713	molecular_function	protein tyrosine kinase activity
H	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
H	0005524	molecular_function	ATP binding
H	0006468	biological_process	protein phosphorylation
H	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
H	0016020	cellular_component	membrane
I	0004672	molecular_function	protein kinase activity
I	0004713	molecular_function	protein tyrosine kinase activity
I	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
I	0005524	molecular_function	ATP binding
I	0006468	biological_process	protein phosphorylation
I	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
I	0016020	cellular_component	membrane
J	0004672	molecular_function	protein kinase activity
J	0004713	molecular_function	protein tyrosine kinase activity
J	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
J	0005524	molecular_function	ATP binding
J	0006468	biological_process	protein phosphorylation
J	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
J	0016020	cellular_component	membrane
K	0004672	molecular_function	protein kinase activity
K	0004713	molecular_function	protein tyrosine kinase activity
K	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
K	0005524	molecular_function	ATP binding
K	0006468	biological_process	protein phosphorylation
K	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
K	0016020	cellular_component	membrane
L	0004672	molecular_function	protein kinase activity
L	0004713	molecular_function	protein tyrosine kinase activity
L	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
L	0005524	molecular_function	ATP binding
L	0006468	biological_process	protein phosphorylation
L	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
L	0016020	cellular_component	membrane
M	0004672	molecular_function	protein kinase activity
M	0004713	molecular_function	protein tyrosine kinase activity
M	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
M	0005524	molecular_function	ATP binding
M	0006468	biological_process	protein phosphorylation
M	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
M	0016020	cellular_component	membrane
R	0004672	molecular_function	protein kinase activity
R	0004713	molecular_function	protein tyrosine kinase activity
R	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
R	0005524	molecular_function	ATP binding
R	0006468	biological_process	protein phosphorylation
R	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
R	0016020	cellular_component	membrane
S	0004672	molecular_function	protein kinase activity
S	0004713	molecular_function	protein tyrosine kinase activity
S	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
S	0005524	molecular_function	ATP binding
S	0006468	biological_process	protein phosphorylation
S	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
S	0016020	cellular_component	membrane
T	0004672	molecular_function	protein kinase activity
T	0004713	molecular_function	protein tyrosine kinase activity
T	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
T	0005524	molecular_function	ATP binding
T	0006468	biological_process	protein phosphorylation
T	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
T	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 741 A 1

Chain	Residue
A	LEU1005
A	GLU1080
A	MET1082
A	THR1083
A	MET1142
A	SER1009
A	ALA1031
A	LYS1033
A	PHE1047
A	GLU1050
A	VAL1063
A	VAL1077
A	MET1079

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 741 B 2

Chain	Residue
B	ALA1031
B	LYS1033
B	PHE1047
B	GLU1050
B	VAL1063
B	VAL1077
B	MET1079
B	GLU1080
B	LEU1081
B	MET1082
B	THR1083
B	GLY1085

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 741 C 3

Chain	Residue
C	LEU1005
C	SER1009
C	ALA1031
C	LYS1033
C	PHE1047
C	GLU1050
C	MET1054
C	VAL1077
C	MET1079
C	GLU1080
C	MET1082
C	THR1083
C	MET1142

site_id	AC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 741 D 4

Chain	Residue
D	LEU1005
D	SER1009
D	ALA1031
D	LYS1033
D	PHE1047
D	GLU1050
D	MET1054
D	VAL1063
D	VAL1077
D	MET1079
D	GLU1080
D	LEU1081
D	MET1082
D	THR1083
D	MET1142

site_id	AC5
Number of Residues	16
Details	BINDING SITE FOR RESIDUE 741 E 5

Chain	Residue
E	LEU1005
E	SER1009
E	ALA1031
E	LYS1033
E	PHE1047
E	GLU1050
E	MET1054
E	VAL1077
E	MET1079
E	GLU1080
E	LEU1081
E	MET1082
E	THR1083
E	ARG1084
E	GLY1085
E	MET1142

site_id	AC6
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 741 F 6

Chain	Residue
F	LEU1005
F	SER1009
F	VAL1013
F	ALA1031
F	LYS1033
F	GLU1050
F	MET1054
F	VAL1077
F	MET1079
F	GLU1080
F	LEU1081
F	MET1082
F	THR1083
F	MET1142

site_id	AC7
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 741 G 7

Chain	Residue
G	LEU1005
G	SER1009
G	VAL1013
G	LYS1033
G	PHE1047
G	GLU1050
G	VAL1063
G	VAL1077
G	MET1079
G	GLU1080
G	LEU1081
G	MET1082
G	THR1083
G	GLY1085
G	MET1142

site_id	AC8
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 741 H 8

Chain	Residue
H	SER1009
H	VAL1013
H	ALA1031
H	LYS1033
H	GLU1050
H	MET1054
H	VAL1077
H	MET1079
H	GLU1080
H	MET1082
H	THR1083
H	MET1142
H	LEU1005

site_id	AC9
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 741 I 9

Chain	Residue
I	LEU1005
I	SER1009
I	LYS1033
I	PHE1047
I	GLU1050
I	VAL1077
I	MET1079
I	GLU1080
I	MET1082
I	THR1083
I	MET1142

site_id	BC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 741 J 10

Chain	Residue
J	HOH111
J	LEU1005
J	SER1009
J	ALA1031
J	LYS1033
J	PHE1047
J	GLU1050
J	MET1054
J	VAL1077
J	MET1079
J	GLU1080
J	LEU1081
J	MET1082
J	THR1083
J	MET1142

site_id	BC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 741 K 11

Chain	Residue
K	LEU1005
K	ALA1031
K	LYS1033
K	PHE1047
K	GLU1050
K	MET1054
K	VAL1077
K	MET1079
K	GLU1080
K	MET1082
K	THR1083
K	MET1142

site_id	BC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 741 M 12

Chain	Residue
M	LEU1005
M	SER1009
M	VAL1013
M	ALA1031
M	LYS1033
M	PHE1047
M	GLU1050
M	VAL1077
M	MET1079
M	GLU1080
M	LEU1081
M	MET1082
M	THR1083
M	MET1142

site_id	BC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 741 L 13

Chain	Residue
L	HOH156
L	LEU1005
L	SER1009
L	VAL1013
L	ALA1031
L	LYS1033
L	PHE1047
L	MET1054
L	VAL1077
L	MET1079
L	GLU1080
L	LEU1081
L	MET1082
L	THR1083
L	MET1142

site_id	BC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 741 R 14

Chain	Residue
R	LEU1005
R	SER1009
R	VAL1013
R	LYS1033
R	PHE1047
R	GLU1050
R	VAL1077
R	MET1079
R	GLU1080
R	MET1082
R	THR1083
R	MET1142

site_id	BC6
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 741 S 15

Chain	Residue
S	LEU1005
S	SER1009
S	VAL1013
S	ALA1031
S	LYS1033
S	PHE1047
S	GLU1050
S	MET1054
S	VAL1077
S	MET1079
S	GLU1080
S	LEU1081
S	MET1082
S	THR1083
S	MET1142

site_id	BC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 741 T 16

Chain	Residue
T	LEU1005
T	ALA1031
T	LYS1033
T	MET1054
T	VAL1063
T	VAL1077
T	MET1079
T	GLU1080
T	MET1082
T	THR1083
T	MET1142

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	29
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGQGSFGMVYeGvakgvvkdepetr.....VAIK

Chain	Residue	Details
A	LEU1005-LYS1033

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDLAARNCMV

Chain	Residue	Details
A	PHE1131-VAL1143

site_id	PS00239
Number of Residues	9
Details	RECEPTOR_TYR_KIN_II Receptor tyrosine kinase class II signature. DIYetdYYR

Chain	Residue	Details
A	ASP1159-ARG1167

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	128
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	16
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	32
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"11694888","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18501599","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19041240","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26584640","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	16
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"11694888","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18501599","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19041240","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	48
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"21994939","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ARG1139
A	ASP1135

site_id	CSA10
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
J	ARG1139
J	ASP1135

site_id	CSA11
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
K	ARG1139
K	ASP1135

site_id	CSA12
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
M	ARG1139
M	ASP1135

site_id	CSA13
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
L	ARG1139
L	ASP1135

site_id	CSA14
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
R	ARG1139
R	ASP1135

site_id	CSA15
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
S	ARG1139
S	ASP1135

site_id	CSA16
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
T	ARG1139
T	ASP1135

site_id	CSA17
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP1135
A	ALA1137

site_id	CSA18
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASP1135
B	ALA1137

site_id	CSA19
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ASP1135
C	ALA1137

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ARG1139
B	ASP1135

site_id	CSA20
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	ASP1135
D	ALA1137

site_id	CSA21
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
E	ASP1135
E	ALA1137

site_id	CSA22
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
F	ASP1135
F	ALA1137

site_id	CSA23
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
G	ASP1135
G	ALA1137

site_id	CSA24
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
H	ASP1135
H	ALA1137

site_id	CSA25
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
I	ASP1135
I	ALA1137

site_id	CSA26
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
J	ASP1135
J	ALA1137

site_id	CSA27
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
K	ASP1135
K	ALA1137

site_id	CSA28
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
M	ASP1135
M	ALA1137

site_id	CSA29
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
L	ASP1135
L	ALA1137

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ARG1139
C	ASP1135

site_id	CSA30
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
R	ASP1135
R	ALA1137

site_id	CSA31
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
S	ASP1135
S	ALA1137

site_id	CSA32
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
T	ASP1135
T	ALA1137

site_id	CSA33
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP1135
A	ASN1140
A	ALA1137

site_id	CSA34
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASP1135
B	ASN1140
B	ALA1137

site_id	CSA35
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ASP1135
C	ASN1140
C	ALA1137

site_id	CSA36
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	ASP1135
D	ASN1140
D	ALA1137

site_id	CSA37
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
E	ASP1135
E	ASN1140
E	ALA1137

site_id	CSA38
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
F	ASP1135
F	ASN1140
F	ALA1137

site_id	CSA39
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
G	ASP1135
G	ASN1140
G	ALA1137

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	ARG1139
D	ASP1135

site_id	CSA40
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
H	ASP1135
H	ASN1140
H	ALA1137

site_id	CSA41
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
I	ASP1135
I	ASN1140
I	ALA1137

site_id	CSA42
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
J	ASP1135
J	ASN1140
J	ALA1137

site_id	CSA43
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
K	ASP1135
K	ASN1140
K	ALA1137

site_id	CSA44
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
M	ASP1135
M	ASN1140
M	ALA1137

site_id	CSA45
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
L	ASP1135
L	ASN1140
L	ALA1137

site_id	CSA46
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
R	ASP1135
R	ASN1140
R	ALA1137

site_id	CSA47
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
S	ASP1135
S	ASN1140
S	ALA1137

site_id	CSA48
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
T	ASP1135
T	ASN1140
T	ALA1137

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
E	ARG1139
E	ASP1135

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
F	ARG1139
F	ASP1135

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
G	ARG1139
G	ASP1135

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
H	ARG1139
H	ASP1135

site_id	CSA9
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
I	ARG1139
I	ASP1135

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)