3F5P
Complex Structure of Insulin-like Growth Factor Receptor and 3-Cyanoquinoline Inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004713 | molecular_function | protein tyrosine kinase activity |
| A | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| A | 0016020 | cellular_component | membrane |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004713 | molecular_function | protein tyrosine kinase activity |
| B | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| B | 0016020 | cellular_component | membrane |
| C | 0004672 | molecular_function | protein kinase activity |
| C | 0004713 | molecular_function | protein tyrosine kinase activity |
| C | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006468 | biological_process | protein phosphorylation |
| C | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| C | 0016020 | cellular_component | membrane |
| D | 0004672 | molecular_function | protein kinase activity |
| D | 0004713 | molecular_function | protein tyrosine kinase activity |
| D | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006468 | biological_process | protein phosphorylation |
| D | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| D | 0016020 | cellular_component | membrane |
| E | 0004672 | molecular_function | protein kinase activity |
| E | 0004713 | molecular_function | protein tyrosine kinase activity |
| E | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| E | 0005524 | molecular_function | ATP binding |
| E | 0006468 | biological_process | protein phosphorylation |
| E | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| E | 0016020 | cellular_component | membrane |
| F | 0004672 | molecular_function | protein kinase activity |
| F | 0004713 | molecular_function | protein tyrosine kinase activity |
| F | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| F | 0005524 | molecular_function | ATP binding |
| F | 0006468 | biological_process | protein phosphorylation |
| F | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| F | 0016020 | cellular_component | membrane |
| G | 0004672 | molecular_function | protein kinase activity |
| G | 0004713 | molecular_function | protein tyrosine kinase activity |
| G | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| G | 0005524 | molecular_function | ATP binding |
| G | 0006468 | biological_process | protein phosphorylation |
| G | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| G | 0016020 | cellular_component | membrane |
| H | 0004672 | molecular_function | protein kinase activity |
| H | 0004713 | molecular_function | protein tyrosine kinase activity |
| H | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| H | 0005524 | molecular_function | ATP binding |
| H | 0006468 | biological_process | protein phosphorylation |
| H | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| H | 0016020 | cellular_component | membrane |
| I | 0004672 | molecular_function | protein kinase activity |
| I | 0004713 | molecular_function | protein tyrosine kinase activity |
| I | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| I | 0005524 | molecular_function | ATP binding |
| I | 0006468 | biological_process | protein phosphorylation |
| I | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| I | 0016020 | cellular_component | membrane |
| J | 0004672 | molecular_function | protein kinase activity |
| J | 0004713 | molecular_function | protein tyrosine kinase activity |
| J | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| J | 0005524 | molecular_function | ATP binding |
| J | 0006468 | biological_process | protein phosphorylation |
| J | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| J | 0016020 | cellular_component | membrane |
| K | 0004672 | molecular_function | protein kinase activity |
| K | 0004713 | molecular_function | protein tyrosine kinase activity |
| K | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| K | 0005524 | molecular_function | ATP binding |
| K | 0006468 | biological_process | protein phosphorylation |
| K | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| K | 0016020 | cellular_component | membrane |
| L | 0004672 | molecular_function | protein kinase activity |
| L | 0004713 | molecular_function | protein tyrosine kinase activity |
| L | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| L | 0005524 | molecular_function | ATP binding |
| L | 0006468 | biological_process | protein phosphorylation |
| L | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| L | 0016020 | cellular_component | membrane |
| M | 0004672 | molecular_function | protein kinase activity |
| M | 0004713 | molecular_function | protein tyrosine kinase activity |
| M | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| M | 0005524 | molecular_function | ATP binding |
| M | 0006468 | biological_process | protein phosphorylation |
| M | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| M | 0016020 | cellular_component | membrane |
| R | 0004672 | molecular_function | protein kinase activity |
| R | 0004713 | molecular_function | protein tyrosine kinase activity |
| R | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| R | 0005524 | molecular_function | ATP binding |
| R | 0006468 | biological_process | protein phosphorylation |
| R | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| R | 0016020 | cellular_component | membrane |
| S | 0004672 | molecular_function | protein kinase activity |
| S | 0004713 | molecular_function | protein tyrosine kinase activity |
| S | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| S | 0005524 | molecular_function | ATP binding |
| S | 0006468 | biological_process | protein phosphorylation |
| S | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| S | 0016020 | cellular_component | membrane |
| T | 0004672 | molecular_function | protein kinase activity |
| T | 0004713 | molecular_function | protein tyrosine kinase activity |
| T | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| T | 0005524 | molecular_function | ATP binding |
| T | 0006468 | biological_process | protein phosphorylation |
| T | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| T | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 741 A 1 |
| Chain | Residue |
| A | LEU1005 |
| A | GLU1080 |
| A | MET1082 |
| A | THR1083 |
| A | MET1142 |
| A | SER1009 |
| A | ALA1031 |
| A | LYS1033 |
| A | PHE1047 |
| A | GLU1050 |
| A | VAL1063 |
| A | VAL1077 |
| A | MET1079 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 741 B 2 |
| Chain | Residue |
| B | ALA1031 |
| B | LYS1033 |
| B | PHE1047 |
| B | GLU1050 |
| B | VAL1063 |
| B | VAL1077 |
| B | MET1079 |
| B | GLU1080 |
| B | LEU1081 |
| B | MET1082 |
| B | THR1083 |
| B | GLY1085 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 741 C 3 |
| Chain | Residue |
| C | LEU1005 |
| C | SER1009 |
| C | ALA1031 |
| C | LYS1033 |
| C | PHE1047 |
| C | GLU1050 |
| C | MET1054 |
| C | VAL1077 |
| C | MET1079 |
| C | GLU1080 |
| C | MET1082 |
| C | THR1083 |
| C | MET1142 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 741 D 4 |
| Chain | Residue |
| D | LEU1005 |
| D | SER1009 |
| D | ALA1031 |
| D | LYS1033 |
| D | PHE1047 |
| D | GLU1050 |
| D | MET1054 |
| D | VAL1063 |
| D | VAL1077 |
| D | MET1079 |
| D | GLU1080 |
| D | LEU1081 |
| D | MET1082 |
| D | THR1083 |
| D | MET1142 |
| site_id | AC5 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE 741 E 5 |
| Chain | Residue |
| E | LEU1005 |
| E | SER1009 |
| E | ALA1031 |
| E | LYS1033 |
| E | PHE1047 |
| E | GLU1050 |
| E | MET1054 |
| E | VAL1077 |
| E | MET1079 |
| E | GLU1080 |
| E | LEU1081 |
| E | MET1082 |
| E | THR1083 |
| E | ARG1084 |
| E | GLY1085 |
| E | MET1142 |
| site_id | AC6 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE 741 F 6 |
| Chain | Residue |
| F | LEU1005 |
| F | SER1009 |
| F | VAL1013 |
| F | ALA1031 |
| F | LYS1033 |
| F | GLU1050 |
| F | MET1054 |
| F | VAL1077 |
| F | MET1079 |
| F | GLU1080 |
| F | LEU1081 |
| F | MET1082 |
| F | THR1083 |
| F | MET1142 |
| site_id | AC7 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 741 G 7 |
| Chain | Residue |
| G | LEU1005 |
| G | SER1009 |
| G | VAL1013 |
| G | LYS1033 |
| G | PHE1047 |
| G | GLU1050 |
| G | VAL1063 |
| G | VAL1077 |
| G | MET1079 |
| G | GLU1080 |
| G | LEU1081 |
| G | MET1082 |
| G | THR1083 |
| G | GLY1085 |
| G | MET1142 |
| site_id | AC8 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 741 H 8 |
| Chain | Residue |
| H | SER1009 |
| H | VAL1013 |
| H | ALA1031 |
| H | LYS1033 |
| H | GLU1050 |
| H | MET1054 |
| H | VAL1077 |
| H | MET1079 |
| H | GLU1080 |
| H | MET1082 |
| H | THR1083 |
| H | MET1142 |
| H | LEU1005 |
| site_id | AC9 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 741 I 9 |
| Chain | Residue |
| I | LEU1005 |
| I | SER1009 |
| I | LYS1033 |
| I | PHE1047 |
| I | GLU1050 |
| I | VAL1077 |
| I | MET1079 |
| I | GLU1080 |
| I | MET1082 |
| I | THR1083 |
| I | MET1142 |
| site_id | BC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 741 J 10 |
| Chain | Residue |
| J | HOH111 |
| J | LEU1005 |
| J | SER1009 |
| J | ALA1031 |
| J | LYS1033 |
| J | PHE1047 |
| J | GLU1050 |
| J | MET1054 |
| J | VAL1077 |
| J | MET1079 |
| J | GLU1080 |
| J | LEU1081 |
| J | MET1082 |
| J | THR1083 |
| J | MET1142 |
| site_id | BC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 741 K 11 |
| Chain | Residue |
| K | LEU1005 |
| K | ALA1031 |
| K | LYS1033 |
| K | PHE1047 |
| K | GLU1050 |
| K | MET1054 |
| K | VAL1077 |
| K | MET1079 |
| K | GLU1080 |
| K | MET1082 |
| K | THR1083 |
| K | MET1142 |
| site_id | BC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE 741 M 12 |
| Chain | Residue |
| M | LEU1005 |
| M | SER1009 |
| M | VAL1013 |
| M | ALA1031 |
| M | LYS1033 |
| M | PHE1047 |
| M | GLU1050 |
| M | VAL1077 |
| M | MET1079 |
| M | GLU1080 |
| M | LEU1081 |
| M | MET1082 |
| M | THR1083 |
| M | MET1142 |
| site_id | BC4 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 741 L 13 |
| Chain | Residue |
| L | HOH156 |
| L | LEU1005 |
| L | SER1009 |
| L | VAL1013 |
| L | ALA1031 |
| L | LYS1033 |
| L | PHE1047 |
| L | MET1054 |
| L | VAL1077 |
| L | MET1079 |
| L | GLU1080 |
| L | LEU1081 |
| L | MET1082 |
| L | THR1083 |
| L | MET1142 |
| site_id | BC5 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 741 R 14 |
| Chain | Residue |
| R | LEU1005 |
| R | SER1009 |
| R | VAL1013 |
| R | LYS1033 |
| R | PHE1047 |
| R | GLU1050 |
| R | VAL1077 |
| R | MET1079 |
| R | GLU1080 |
| R | MET1082 |
| R | THR1083 |
| R | MET1142 |
| site_id | BC6 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 741 S 15 |
| Chain | Residue |
| S | LEU1005 |
| S | SER1009 |
| S | VAL1013 |
| S | ALA1031 |
| S | LYS1033 |
| S | PHE1047 |
| S | GLU1050 |
| S | MET1054 |
| S | VAL1077 |
| S | MET1079 |
| S | GLU1080 |
| S | LEU1081 |
| S | MET1082 |
| S | THR1083 |
| S | MET1142 |
| site_id | BC7 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 741 T 16 |
| Chain | Residue |
| T | LEU1005 |
| T | ALA1031 |
| T | LYS1033 |
| T | MET1054 |
| T | VAL1063 |
| T | VAL1077 |
| T | MET1079 |
| T | GLU1080 |
| T | MET1082 |
| T | THR1083 |
| T | MET1142 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 29 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGQGSFGMVYeGvakgvvkdepetr.....VAIK |
| Chain | Residue | Details |
| A | LEU1005-LYS1033 |
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDLAARNCMV |
| Chain | Residue | Details |
| A | PHE1131-VAL1143 |
| site_id | PS00239 |
| Number of Residues | 9 |
| Details | RECEPTOR_TYR_KIN_II Receptor tyrosine kinase class II signature. DIYetdYYR |
| Chain | Residue | Details |
| A | ASP1159-ARG1167 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 |
| Chain | Residue | Details |
| A | ASP1135 | |
| J | ASP1135 | |
| K | ASP1135 | |
| M | ASP1135 | |
| L | ASP1135 | |
| R | ASP1135 | |
| S | ASP1135 | |
| T | ASP1135 | |
| B | ASP1135 | |
| C | ASP1135 | |
| D | ASP1135 | |
| E | ASP1135 | |
| F | ASP1135 | |
| G | ASP1135 | |
| H | ASP1135 | |
| I | ASP1135 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
| Chain | Residue | Details |
| A | LEU1005 | |
| J | LEU1005 | |
| K | LEU1005 | |
| M | LEU1005 | |
| L | LEU1005 | |
| R | LEU1005 | |
| S | LEU1005 | |
| T | LEU1005 | |
| B | LEU1005 | |
| C | LEU1005 | |
| D | LEU1005 | |
| E | LEU1005 | |
| F | LEU1005 | |
| G | LEU1005 | |
| H | LEU1005 | |
| I | LEU1005 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | LYS1033 | |
| J | LYS1033 | |
| K | LYS1033 | |
| M | LYS1033 | |
| L | LYS1033 | |
| R | LYS1033 | |
| S | LYS1033 | |
| T | LYS1033 | |
| B | LYS1033 | |
| C | LYS1033 | |
| D | LYS1033 | |
| E | LYS1033 | |
| F | LYS1033 | |
| G | LYS1033 | |
| H | LYS1033 | |
| I | LYS1033 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 48 |
| Details | MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:11694888, ECO:0000269|PubMed:18501599, ECO:0000269|PubMed:19041240 |
| Chain | Residue | Details |
| A | PTR1161 | |
| D | PTR1161 | |
| D | PTR1165 | |
| D | PTR1166 | |
| E | PTR1161 | |
| E | PTR1165 | |
| E | PTR1166 | |
| F | PTR1161 | |
| F | PTR1165 | |
| F | PTR1166 | |
| G | PTR1161 | |
| A | PTR1165 | |
| G | PTR1165 | |
| G | PTR1166 | |
| H | PTR1161 | |
| H | PTR1165 | |
| H | PTR1166 | |
| I | PTR1161 | |
| I | PTR1165 | |
| I | PTR1166 | |
| J | PTR1161 | |
| J | PTR1165 | |
| A | PTR1166 | |
| J | PTR1166 | |
| K | PTR1161 | |
| K | PTR1165 | |
| K | PTR1166 | |
| M | PTR1161 | |
| M | PTR1165 | |
| M | PTR1166 | |
| L | PTR1161 | |
| L | PTR1165 | |
| L | PTR1166 | |
| B | PTR1161 | |
| R | PTR1161 | |
| R | PTR1165 | |
| R | PTR1166 | |
| S | PTR1161 | |
| S | PTR1165 | |
| S | PTR1166 | |
| T | PTR1161 | |
| T | PTR1165 | |
| T | PTR1166 | |
| B | PTR1165 | |
| B | PTR1166 | |
| C | PTR1161 | |
| C | PTR1165 | |
| C | PTR1166 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 16 |
| Details | MOD_RES: Phosphoserine; by GSK3-beta => ECO:0000250|UniProtKB:Q60751 |
| Chain | Residue | Details |
| A | SER1278 | |
| J | SER1278 | |
| K | SER1278 | |
| M | SER1278 | |
| L | SER1278 | |
| R | SER1278 | |
| S | SER1278 | |
| T | SER1278 | |
| B | SER1278 | |
| C | SER1278 | |
| D | SER1278 | |
| E | SER1278 | |
| F | SER1278 | |
| G | SER1278 | |
| H | SER1278 | |
| I | SER1278 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 16 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q60751 |
| Chain | Residue | Details |
| A | SER1282 | |
| J | SER1282 | |
| K | SER1282 | |
| M | SER1282 | |
| L | SER1282 | |
| R | SER1282 | |
| S | SER1282 | |
| T | SER1282 | |
| B | SER1282 | |
| C | SER1282 | |
| D | SER1282 | |
| E | SER1282 | |
| F | SER1282 | |
| G | SER1282 | |
| H | SER1282 | |
| I | SER1282 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 48 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:21994939 |
| Chain | Residue | Details |
| A | LYS1168 | |
| D | LYS1168 | |
| D | LYS1171 | |
| E | LYS1168 | |
| E | LYS1171 | |
| F | LYS1168 | |
| F | LYS1171 | |
| G | LYS1168 | |
| G | LYS1171 | |
| H | LYS1168 | |
| H | LYS1171 | |
| I | LYS1168 | |
| I | LYS1171 | |
| J | LYS1168 | |
| A | LYS1171 | |
| J | LYS1171 | |
| K | LYS1168 | |
| K | LYS1171 | |
| M | LYS1168 | |
| M | LYS1171 | |
| L | LYS1168 | |
| L | LYS1171 | |
| B | LYS1168 | |
| R | LYS1168 | |
| R | LYS1171 | |
| S | LYS1168 | |
| S | LYS1171 | |
| T | LYS1168 | |
| T | LYS1171 | |
| B | LYS1171 | |
| C | LYS1168 | |
| C | LYS1171 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | ARG1139 | |
| A | ASP1135 |
| site_id | CSA10 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| J | ARG1139 | |
| J | ASP1135 |
| site_id | CSA11 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| K | ARG1139 | |
| K | ASP1135 |
| site_id | CSA12 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| M | ARG1139 | |
| M | ASP1135 |
| site_id | CSA13 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| L | ARG1139 | |
| L | ASP1135 |
| site_id | CSA14 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| R | ARG1139 | |
| R | ASP1135 |
| site_id | CSA15 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| S | ARG1139 | |
| S | ASP1135 |
| site_id | CSA16 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| T | ARG1139 | |
| T | ASP1135 |
| site_id | CSA17 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | ASP1135 | |
| A | ALA1137 |
| site_id | CSA18 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| B | ASP1135 | |
| B | ALA1137 |
| site_id | CSA19 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| C | ASP1135 | |
| C | ALA1137 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| B | ARG1139 | |
| B | ASP1135 |
| site_id | CSA20 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| D | ASP1135 | |
| D | ALA1137 |
| site_id | CSA21 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| E | ASP1135 | |
| E | ALA1137 |
| site_id | CSA22 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| F | ASP1135 | |
| F | ALA1137 |
| site_id | CSA23 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| G | ASP1135 | |
| G | ALA1137 |
| site_id | CSA24 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| H | ASP1135 | |
| H | ALA1137 |
| site_id | CSA25 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| I | ASP1135 | |
| I | ALA1137 |
| site_id | CSA26 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| J | ASP1135 | |
| J | ALA1137 |
| site_id | CSA27 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| K | ASP1135 | |
| K | ALA1137 |
| site_id | CSA28 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| M | ASP1135 | |
| M | ALA1137 |
| site_id | CSA29 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| L | ASP1135 | |
| L | ALA1137 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| C | ARG1139 | |
| C | ASP1135 |
| site_id | CSA30 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| R | ASP1135 | |
| R | ALA1137 |
| site_id | CSA31 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| S | ASP1135 | |
| S | ALA1137 |
| site_id | CSA32 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| T | ASP1135 | |
| T | ALA1137 |
| site_id | CSA33 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | ASP1135 | |
| A | ASN1140 | |
| A | ALA1137 |
| site_id | CSA34 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| B | ASP1135 | |
| B | ASN1140 | |
| B | ALA1137 |
| site_id | CSA35 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| C | ASP1135 | |
| C | ASN1140 | |
| C | ALA1137 |
| site_id | CSA36 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| D | ASP1135 | |
| D | ASN1140 | |
| D | ALA1137 |
| site_id | CSA37 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| E | ASP1135 | |
| E | ASN1140 | |
| E | ALA1137 |
| site_id | CSA38 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| F | ASP1135 | |
| F | ASN1140 | |
| F | ALA1137 |
| site_id | CSA39 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| G | ASP1135 | |
| G | ASN1140 | |
| G | ALA1137 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| D | ARG1139 | |
| D | ASP1135 |
| site_id | CSA40 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| H | ASP1135 | |
| H | ASN1140 | |
| H | ALA1137 |
| site_id | CSA41 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| I | ASP1135 | |
| I | ASN1140 | |
| I | ALA1137 |
| site_id | CSA42 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| J | ASP1135 | |
| J | ASN1140 | |
| J | ALA1137 |
| site_id | CSA43 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| K | ASP1135 | |
| K | ASN1140 | |
| K | ALA1137 |
| site_id | CSA44 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| M | ASP1135 | |
| M | ASN1140 | |
| M | ALA1137 |
| site_id | CSA45 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| L | ASP1135 | |
| L | ASN1140 | |
| L | ALA1137 |
| site_id | CSA46 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| R | ASP1135 | |
| R | ASN1140 | |
| R | ALA1137 |
| site_id | CSA47 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| S | ASP1135 | |
| S | ASN1140 | |
| S | ALA1137 |
| site_id | CSA48 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| T | ASP1135 | |
| T | ASN1140 | |
| T | ALA1137 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| E | ARG1139 | |
| E | ASP1135 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| F | ARG1139 | |
| F | ASP1135 |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| G | ARG1139 | |
| G | ASP1135 |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| H | ARG1139 | |
| H | ASP1135 |
| site_id | CSA9 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| I | ARG1139 | |
| I | ASP1135 |
