3EZZ
Crystal Structure of human MKP-2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006470 | biological_process | protein dephosphorylation |
| A | 0016311 | biological_process | dephosphorylation |
| A | 0017017 | molecular_function | MAP kinase tyrosine/serine/threonine phosphatase activity |
| B | 0006470 | biological_process | protein dephosphorylation |
| B | 0016311 | biological_process | dephosphorylation |
| B | 0017017 | molecular_function | MAP kinase tyrosine/serine/threonine phosphatase activity |
| C | 0006470 | biological_process | protein dephosphorylation |
| C | 0016311 | biological_process | dephosphorylation |
| C | 0017017 | molecular_function | MAP kinase tyrosine/serine/threonine phosphatase activity |
| D | 0006470 | biological_process | protein dephosphorylation |
| D | 0016311 | biological_process | dephosphorylation |
| D | 0017017 | molecular_function | MAP kinase tyrosine/serine/threonine phosphatase activity |
| E | 0006470 | biological_process | protein dephosphorylation |
| E | 0016311 | biological_process | dephosphorylation |
| E | 0017017 | molecular_function | MAP kinase tyrosine/serine/threonine phosphatase activity |
| F | 0006470 | biological_process | protein dephosphorylation |
| F | 0016311 | biological_process | dephosphorylation |
| F | 0017017 | molecular_function | MAP kinase tyrosine/serine/threonine phosphatase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 501 |
| Chain | Residue |
| A | ASP249 |
| A | SER280 |
| A | GLN281 |
| A | ALA282 |
| A | GLY283 |
| A | ILE284 |
| A | SER285 |
| A | ARG286 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 502 |
| Chain | Residue |
| B | GLN281 |
| B | ALA282 |
| B | GLY283 |
| B | ILE284 |
| B | SER285 |
| B | ARG286 |
| B | SER280 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 C 503 |
| Chain | Residue |
| C | ASP249 |
| C | SER280 |
| C | GLN281 |
| C | ALA282 |
| C | GLY283 |
| C | ILE284 |
| C | SER285 |
| C | ARG286 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 D 504 |
| Chain | Residue |
| D | ASP249 |
| D | SER280 |
| D | GLN281 |
| D | ALA282 |
| D | GLY283 |
| D | ILE284 |
| D | SER285 |
| D | ARG286 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 E 505 |
| Chain | Residue |
| E | SER280 |
| E | GLN281 |
| E | ALA282 |
| E | GLY283 |
| E | ILE284 |
| E | SER285 |
| E | ARG286 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 F 506 |
| Chain | Residue |
| F | SER280 |
| F | GLN281 |
| F | ALA282 |
| F | GLY283 |
| F | ILE284 |
| F | SER285 |
| F | ARG286 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 507 |
| Chain | Residue |
| A | ARG214 |
| A | ARG214 |
| A | ARG214 |
| A | ARG214 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 508 |
| Chain | Residue |
| D | ARG214 |
| D | ARG214 |
| D | ARG214 |
| D | ARG214 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 509 |
| Chain | Residue |
| B | ARG214 |
| C | ARG214 |
| E | ARG214 |
| F | ARG214 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | ACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160 |
| Chain | Residue | Details |
| A | SER280 | |
| B | SER280 | |
| C | SER280 | |
| D | SER280 | |
| E | SER280 | |
| F | SER280 |
