3EYW
Crystal structure of the C-terminal domain of E. coli KefC in complex with KefF
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003955 | molecular_function | NAD(P)H dehydrogenase (quinone) activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0008753 | molecular_function | NADPH dehydrogenase (quinone) activity |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0010181 | molecular_function | FMN binding |
| A | 0015079 | molecular_function | potassium ion transmembrane transporter activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0050136 | molecular_function | NADH:ubiquinone reductase (non-electrogenic) activity |
| A | 0051453 | biological_process | regulation of intracellular pH |
| A | 0051454 | biological_process | intracellular pH elevation |
| A | 1901381 | biological_process | positive regulation of potassium ion transmembrane transport |
| A | 1903103 | cellular_component | potassium:proton antiporter complex |
| B | 0003955 | molecular_function | NAD(P)H dehydrogenase (quinone) activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006813 | biological_process | potassium ion transport |
| B | 0008753 | molecular_function | NADPH dehydrogenase (quinone) activity |
| B | 0009055 | molecular_function | electron transfer activity |
| B | 0010181 | molecular_function | FMN binding |
| B | 0015079 | molecular_function | potassium ion transmembrane transporter activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0050136 | molecular_function | NADH:ubiquinone reductase (non-electrogenic) activity |
| B | 0051453 | biological_process | regulation of intracellular pH |
| B | 0051454 | biological_process | intracellular pH elevation |
| B | 1901381 | biological_process | positive regulation of potassium ion transmembrane transport |
| B | 1903103 | cellular_component | potassium:proton antiporter complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE FMN A2400 |
| Chain | Residue |
| A | HIS1008 |
| A | TYR1068 |
| A | THR1105 |
| A | THR1106 |
| A | GLY1107 |
| A | GLY1108 |
| A | PHE1113 |
| A | THR1148 |
| A | SER1014 |
| A | HIS1015 |
| A | ALA1016 |
| A | ASN1017 |
| A | PRO1064 |
| A | MET1065 |
| A | GLN1066 |
| A | TRP1067 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE NAD A2401 |
| Chain | Residue |
| A | HOH127 |
| A | HOH161 |
| A | GLY406 |
| A | GLY408 |
| A | ARG409 |
| A | PHE410 |
| A | ASP429 |
| A | HIS430 |
| A | ASP431 |
| A | HIS434 |
| A | GLY448 |
| A | ASP449 |
| A | ALA450 |
| A | ILE471 |
| A | ASP472 |
| A | THR476 |
| A | ARG496 |
| A | MG2403 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A2403 |
| Chain | Residue |
| A | GLY406 |
| A | GLY408 |
| A | GLY411 |
| A | ALA470 |
| A | ARG496 |
| A | NAD2401 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A2402 |
| Chain | Residue |
| A | TYR1010 |
| A | PRO1011 |
| A | HIS1012 |
| B | HOH61 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B2402 |
| Chain | Residue |
| A | HOH99 |
| B | TYR1010 |
| B | PRO1011 |
| B | HIS1012 |
| B | HIS1013 |
| site_id | AC6 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE FMN B2400 |
| Chain | Residue |
| B | HOH97 |
| B | HOH162 |
| B | HOH191 |
| B | HIS1008 |
| B | SER1014 |
| B | HIS1015 |
| B | ALA1016 |
| B | ASN1017 |
| B | PRO1064 |
| B | MET1065 |
| B | GLN1066 |
| B | TRP1067 |
| B | TYR1068 |
| B | THR1105 |
| B | THR1106 |
| B | GLY1107 |
| B | GLY1108 |
| B | HIS1112 |
| B | PHE1113 |
| B | THR1148 |
| site_id | AC7 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE NAD B2401 |
| Chain | Residue |
| B | HOH128 |
| B | HOH129 |
| B | GLY406 |
| B | GLY408 |
| B | ARG409 |
| B | PHE410 |
| B | ASP429 |
| B | HIS430 |
| B | ASP431 |
| B | HIS434 |
| B | GLY448 |
| B | ASP449 |
| B | ALA450 |
| B | ASP472 |
| B | THR476 |
| B | ARG496 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:19523906 |
| Chain | Residue | Details |
| A | GLY408 | |
| B | ASP449 | |
| B | ASP472 | |
| B | ARG496 | |
| A | ASP429 | |
| A | HIS434 | |
| A | ASP449 | |
| A | ASP472 | |
| A | ARG496 | |
| B | GLY408 | |
| B | ASP429 | |
| B | HIS434 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | GLN412 | |
| B | GLN412 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: in other chain |
| Chain | Residue | Details |
| A | ARG498 | |
| A | ARG516 | |
| B | ARG498 | |
| B | ARG516 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01414, ECO:0000269|PubMed:19523906, ECO:0000269|PubMed:21041667 |
| Chain | Residue | Details |
| A | HIS1008 | |
| A | SER1014 | |
| A | MET1065 | |
| A | THR1105 | |
| B | HIS1008 | |
| B | SER1014 | |
| B | MET1065 | |
| B | THR1105 |
