3EW3
the 1:2 complex between a Nterminal elongated prolactin and the extra cellular domain of the rat prolactin receptor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001937 | biological_process | negative regulation of endothelial cell proliferation |
| A | 0005148 | molecular_function | prolactin receptor binding |
| A | 0005179 | molecular_function | hormone activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0007166 | biological_process | cell surface receptor signaling pathway |
| A | 0007565 | biological_process | female pregnancy |
| A | 0007595 | biological_process | lactation |
| A | 0008284 | biological_process | positive regulation of cell population proliferation |
| A | 0016525 | biological_process | negative regulation of angiogenesis |
| A | 0030879 | biological_process | mammary gland development |
| A | 0031667 | biological_process | response to nutrient levels |
| A | 0031904 | cellular_component | endosome lumen |
| A | 0038161 | biological_process | prolactin signaling pathway |
| A | 0043123 | biological_process | positive regulation of canonical NF-kappaB signal transduction |
| A | 0046427 | biological_process | positive regulation of receptor signaling pathway via JAK-STAT |
| A | 1902895 | biological_process | positive regulation of miRNA transcription |
| A | 1903489 | biological_process | positive regulation of lactation |
| B | 0004896 | molecular_function | cytokine receptor activity |
| B | 0016020 | cellular_component | membrane |
| C | 0004896 | molecular_function | cytokine receptor activity |
| C | 0016020 | cellular_component | membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00266 |
| Number of Residues | 34 |
| Details | SOMATOTROPIN_1 Somatotropin, prolactin and related hormones signature 1. ChTssLaTPedkeqAqqmnqkdFlslivsIlrSW |
| Chain | Residue | Details |
| A | CYS58-TRP91 |
| site_id | PS00338 |
| Number of Residues | 18 |
| Details | SOMATOTROPIN_2 Somatotropin, prolactin and related hormones signature 2. CLRrDShKIDnYlkLlkC |
| Chain | Residue | Details |
| A | CYS174-CYS191 |
| site_id | PS01352 |
| Number of Residues | 78 |
| Details | HEMATOPO_REC_L_F1 Long hematopoietin receptor, single chain family signature. LwVkWspptitdvktgwftmeYEIrlkpeeaeeweihftghqtqfkvfd..LypgqkylvqtRcKpdhgy....WsrWsqessV |
| Chain | Residue | Details |
| B | LEU123-VAL200 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 418 |
| Details | TOPO_DOM: Extracellular => ECO:0000250 |
| Chain | Residue | Details |
| B | GLN1-ASP210 | |
| C | GLN1-ASP210 | |
| A | SER90 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| B | ASP187 | |
| B | HIS188 | |
| C | ASP187 | |
| C | HIS188 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine |
| Chain | Residue | Details |
| B | ASN35 | |
| B | ASN80 | |
| C | ASN35 | |
| C | ASN80 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| B | ASN108 | |
| C | ASN108 |
