3EUE
Crystal structure of ligand-free human uridine phosphorylase 1 (hUPP1)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004850 | molecular_function | uridine phosphorylase activity |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| A | 0006218 | biological_process | uridine catabolic process |
| A | 0006248 | biological_process | CMP catabolic process |
| A | 0006249 | biological_process | dCMP catabolic process |
| A | 0009032 | molecular_function | thymidine phosphorylase activity |
| A | 0009116 | biological_process | nucleoside metabolic process |
| A | 0009166 | biological_process | nucleotide catabolic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0016763 | molecular_function | pentosyltransferase activity |
| A | 0042149 | biological_process | cellular response to glucose starvation |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0044206 | biological_process | UMP salvage |
| A | 0046050 | biological_process | UMP catabolic process |
| A | 0046074 | biological_process | dTMP catabolic process |
| A | 0046079 | biological_process | dUMP catabolic process |
| A | 0047847 | molecular_function | deoxyuridine phosphorylase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 311 |
| Chain | Residue |
| A | SER116 |
| A | ILE117 |
| A | HIS120 |
| A | ASP212 |
| A | PHE213 |
| A | TYR214 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 312 |
| Chain | Residue |
| A | HOH399 |
| A | HOH424 |
| A | HOH436 |
| A | GLY60 |
| A | SER61 |
| A | ARG64 |
Functional Information from PROSITE/UniProt
| site_id | PS01232 |
| Number of Residues | 16 |
| Details | PNP_UDP_1 Purine and other phosphorylases family 1 signature. ShGMGiPSiSImlhEL |
| Chain | Residue | Details |
| A | SER107-LEU122 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19291308","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3EUF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20856879","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3EUF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NBQ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19291308","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"20856879","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3EUF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NBQ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1t0u |
| Chain | Residue | Details |
| A | GLU121 | |
| A | ARG275 | |
| A | HIS36 |
