Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K A 1 |
| Chain | Residue |
| A | SER32 |
| A | THR35 |
| A | EDO459 |
| A | HOH534 |
| A | HOH584 |
| B | ASP100 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE K D 2 |
| Chain | Residue |
| C | TYR169 |
| C | HOH505 |
| D | SER32 |
| D | THR35 |
| A | HOH676 |
| C | K5 |
| C | ASP100 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE K C 3 |
| Chain | Residue |
| A | HOH702 |
| A | HOH785 |
| C | SER32 |
| C | THR35 |
| C | EDO459 |
| D | ASP100 |
| D | TYR169 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE K B 4 |
| Chain | Residue |
| A | ASP100 |
| A | TYR169 |
| A | HOH667 |
| A | HOH681 |
| B | EDO8 |
| B | SER32 |
| B | THR35 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE K C 5 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 6 |
| Chain | Residue |
| B | HIS378 |
| B | GLU382 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO C 7 |
| Chain | Residue |
| A | HOH756 |
| A | HOH800 |
| C | ARG307 |
| C | ARG314 |
| C | GLN372 |
| D | PRO80 |
| D | GLU81 |
| D | GLU137 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO B 8 |
| Chain | Residue |
| A | ILE99 |
| A | ASP100 |
| A | TYR169 |
| B | K4 |
| B | SER33 |
| B | THR35 |
| B | LEU37 |
| B | EDO460 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 9 |
| Chain | Residue |
| A | EDO12 |
| A | GLY102 |
| A | SER105 |
| A | HOH652 |
| B | THR45 |
| B | ARG49 |
| B | TYR381 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 10 |
| Chain | Residue |
| B | GLN439 |
| B | LYS443 |
| B | PHE447 |
| B | VAL449 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 11 |
| Chain | Residue |
| A | EDO12 |
| A | ARG48 |
| A | PHE51 |
| A | ASN52 |
| A | TYR103 |
| A | HOH1074 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 12 |
| Chain | Residue |
| A | EDO11 |
| A | GLY102 |
| A | TYR103 |
| A | HOH847 |
| B | EDO9 |
| B | EDO14 |
| B | ARG48 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 13 |
| Chain | Residue |
| A | ARG48 |
| A | EDO475 |
| A | HOH1074 |
| B | EDO14 |
| B | GLY102 |
| B | TYR103 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 14 |
| Chain | Residue |
| A | EDO12 |
| A | EDO13 |
| A | HOH847 |
| B | ASN52 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO C 15 |
| Chain | Residue |
| C | EDO17 |
| C | ARG48 |
| C | EDO460 |
| D | GLY102 |
| D | TYR103 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO C 16 |
| Chain | Residue |
| C | THR35 |
| C | EDO456 |
| C | EDO459 |
| D | ARG106 |
| site_id | BC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO C 17 |
| Chain | Residue |
| C | EDO15 |
| C | EDO460 |
| D | PHE51 |
| D | ASN52 |
| D | HOH533 |
| D | HOH594 |
| site_id | BC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 18 |
| Chain | Residue |
| B | ASP330 |
| B | CYS331 |
| B | HOH596 |
| B | GLY326 |
| B | GLY328 |
| B | PRO329 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO C 19 |
| Chain | Residue |
| C | GLY326 |
| C | GLY328 |
| C | PRO329 |
| C | ASP330 |
| C | HIS379 |
| site_id | CC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 20 |
| Chain | Residue |
| A | GLU266 |
| A | HIS268 |
| A | GLU305 |
| A | ASN308 |
| A | HOH759 |
| A | HOH875 |
| site_id | CC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 21 |
| Chain | Residue |
| A | GLU225 |
| A | HOH569 |
| A | HOH826 |
| site_id | CC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 452 |
| Chain | Residue |
| A | ASN61 |
| A | LYS115 |
| A | PHE119 |
| A | LYS122 |
| site_id | CC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO C 452 |
| Chain | Residue |
| C | ARG307 |
| C | THR369 |
| C | PRO370 |
| C | ASP371 |
| C | GLN372 |
| D | GLY79 |
| D | GLU81 |
| site_id | CC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO C 453 |
| Chain | Residue |
| C | ARG106 |
| C | GLU107 |
| C | LEU110 |
| C | SER174 |
| C | GLU176 |
| C | GLU177 |
| site_id | CC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO D 452 |
| Chain | Residue |
| D | GLU266 |
| D | HIS268 |
| D | GLU305 |
| D | ASN308 |
| D | HOH500 |
| D | HOH502 |
| site_id | CC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 452 |
| Chain | Residue |
| B | TYR69 |
| B | HIS70 |
| B | TYR75 |
| B | HOH571 |
| site_id | CC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 453 |
| Chain | Residue |
| B | ARG319 |
| B | HIS323 |
| B | HOH620 |
| site_id | DC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO D 453 |
| Chain | Residue |
| D | VAL367 |
| D | TYR423 |
| D | TRP429 |
| D | EDO458 |
| site_id | DC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO D 454 |
| Chain | Residue |
| D | GLU114 |
| D | ARG183 |
| site_id | DC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 453 |
| Chain | Residue |
| A | MSE71 |
| A | TYR394 |
| A | LYS406 |
| A | HOH1024 |
| B | EDO457 |
| site_id | DC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 454 |
| Chain | Residue |
| A | GLU74 |
| A | PRO76 |
| A | ARG407 |
| site_id | DC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO C 454 |
| Chain | Residue |
| C | ARG270 |
| C | GLY273 |
| site_id | DC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 454 |
| Chain | Residue |
| B | ARG197 |
| B | ASN202 |
| B | PRO242 |
| B | ALA244 |
| B | HOH482 |
| site_id | DC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 455 |
| Chain | Residue |
| A | VAL292 |
| A | VAL367 |
| A | TYR423 |
| A | EDO468 |
| site_id | DC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO C 455 |
| Chain | Residue |
| A | HOH763 |
| A | HOH800 |
| C | ARG307 |
| C | ASN308 |
| D | PRO80 |
| site_id | DC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 456 |
| Chain | Residue |
| A | SER36 |
| A | LEU37 |
| A | HIS378 |
| A | TYR381 |
| A | GLU382 |
| site_id | EC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO C 456 |
| Chain | Residue |
| C | EDO16 |
| C | SER36 |
| C | LEU37 |
| C | HIS378 |
| C | TYR381 |
| C | GLU382 |
| site_id | EC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 457 |
| Chain | Residue |
| A | GLY326 |
| A | GLY328 |
| A | PRO329 |
| A | ASP330 |
| A | HOH1021 |
| site_id | EC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO C 457 |
| Chain | Residue |
| A | HOH1005 |
| C | ALA171 |
| C | LYS178 |
| C | HOH609 |
| site_id | EC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 458 |
| Chain | Residue |
| A | GLU107 |
| A | LEU110 |
| A | SER174 |
| A | HOH1033 |
| site_id | EC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO C 458 |
| Chain | Residue |
| C | ASP100 |
| C | THR425 |
| C | LEU427 |
| C | LYS430 |
| D | HOH529 |
| site_id | EC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 455 |
| Chain | Residue |
| B | ARG106 |
| B | GLU107 |
| B | LEU110 |
| B | SER174 |
| B | GLU176 |
| B | HOH593 |
| site_id | EC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO D 455 |
| Chain | Residue |
| D | GLU107 |
| D | LEU110 |
| D | SER174 |
| D | GLU176 |
| D | HOH668 |
| site_id | EC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 459 |
| Chain | Residue |
| A | K1 |
| A | SER33 |
| A | THR35 |
| A | LEU37 |
| A | HOH1046 |
| B | ILE99 |
| B | ASP100 |
| site_id | EC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO C 459 |
| Chain | Residue |
| C | K3 |
| C | EDO16 |
| C | SER33 |
| C | THR35 |
| C | LEU37 |
| D | ILE99 |
| D | ASP100 |
| D | TYR169 |
| site_id | FC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO C 460 |
| Chain | Residue |
| A | HOH829 |
| C | EDO15 |
| C | EDO17 |
| C | ARG48 |
| C | PHE51 |
| C | ASN52 |
| D | ARG48 |
| site_id | FC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO D 456 |
| Chain | Residue |
| D | GLY326 |
| D | GLY328 |
| D | PRO329 |
| D | ASP330 |
| D | HIS379 |
| site_id | FC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO A 460 |
| site_id | FC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 461 |
| Chain | Residue |
| A | GLU114 |
| A | ARG183 |
| A | HOH1075 |
| site_id | FC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 462 |
| Chain | Residue |
| A | LYS295 |
| A | ASP296 |
| A | ASN448 |
| site_id | FC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO C 461 |
| Chain | Residue |
| C | TYR381 |
| C | GLY384 |
| D | SER105 |
| site_id | FC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO B 456 |
| Chain | Residue |
| A | HOH675 |
| B | GLU263 |
| site_id | FC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO C 462 |
| Chain | Residue |
| C | ASP290 |
| C | TRP429 |
| C | LYS451 |
| site_id | FC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 457 |
| Chain | Residue |
| A | MSE71 |
| A | EDO453 |
| B | GLU266 |
| site_id | GC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 458 |
| Chain | Residue |
| A | PRO80 |
| A | GLU81 |
| A | GLU137 |
| B | ARG307 |
| B | ARG314 |
| B | GLN372 |
| B | HOH577 |
| site_id | GC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 459 |
| Chain | Residue |
| A | GLY79 |
| A | GLU81 |
| B | ARG307 |
| B | THR369 |
| B | PRO370 |
| B | ASP371 |
| B | GLN372 |
| site_id | GC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO D 457 |
| Chain | Residue |
| D | ASP39 |
| D | ASP371 |
| D | HIS378 |
| site_id | GC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO D 458 |
| Chain | Residue |
| D | PHE303 |
| D | EDO453 |
| D | EDO460 |
| site_id | GC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 463 |
| Chain | Residue |
| A | ASP402 |
| A | TRP403 |
| A | TYR404 |
| A | EDO465 |
| A | HOH787 |
| B | LYS451 |
| site_id | GC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 464 |
| Chain | Residue |
| A | GLY200 |
| A | HOH890 |
| site_id | GC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 465 |
| Chain | Residue |
| A | ALA401 |
| A | ASP402 |
| A | EDO463 |
| A | HOH921 |
| site_id | GC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 466 |
| Chain | Residue |
| A | ASN308 |
| A | LEU311 |
| A | EDO467 |
| site_id | GC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 467 |
| Chain | Residue |
| A | ASN304 |
| A | ARG307 |
| A | ASN308 |
| A | EDO466 |
| A | HOH1057 |
| site_id | HC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 460 |
| Chain | Residue |
| B | EDO8 |
| B | ALA34 |
| B | THR35 |
| site_id | HC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 468 |
| Chain | Residue |
| A | ARG307 |
| A | VAL367 |
| A | PRO370 |
| A | EDO455 |
| site_id | HC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO C 463 |
| Chain | Residue |
| C | PRO436 |
| C | HOH501 |
| C | HOH609 |
| site_id | HC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 461 |
| Chain | Residue |
| A | GLU74 |
| B | VAL367 |
| B | HOH680 |
| site_id | HC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO C 464 |
| Chain | Residue |
| C | ASP290 |
| C | LYS430 |
| C | LYS451 |
| C | HOH492 |
| site_id | HC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 462 |
| Chain | Residue |
| A | HOH625 |
| B | ALA276 |
| B | GLY277 |
| B | GLY347 |
| B | LEU349 |
| B | ASP352 |
| B | HOH499 |
| site_id | HC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO D 459 |
| Chain | Residue |
| D | MSE71 |
| D | TYR391 |
| D | HOH499 |
| site_id | HC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO D 460 |
| Chain | Residue |
| D | VAL292 |
| D | GLY293 |
| D | SER301 |
| D | EDO458 |
| D | HOH645 |
| site_id | HC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 469 |
| Chain | Residue |
| A | ASP100 |
| A | THR425 |
| A | LEU427 |
| A | LYS430 |
| A | HOH961 |
| site_id | IC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 470 |
| Chain | Residue |
| A | GLU67 |
| A | TYR338 |
| A | LEU409 |
| A | HOH984 |
| site_id | IC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO D 461 |
| Chain | Residue |
| D | ALA276 |
| D | GLY277 |
| D | GLY347 |
| D | LEU349 |
| D | ASP352 |
| D | HOH586 |
| site_id | IC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 471 |
| Chain | Residue |
| A | LYS122 |
| A | ASP124 |
| A | THR138 |
| A | GLY139 |
| A | HIS140 |
| site_id | IC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 472 |
| Chain | Residue |
| A | ARG68 |
| A | ILE82 |
| A | TRP133 |
| site_id | IC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 473 |
| Chain | Residue |
| A | GLN439 |
| A | LYS443 |
| A | PHE447 |
| site_id | IC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO B 463 |
| Chain | Residue |
| B | PHE54 |
| B | GLY63 |
| B | LEU64 |
| B | ALA65 |
| B | SER88 |
| B | GLY91 |
| B | ILE95 |
| B | ARG112 |
| B | ILE116 |
| site_id | IC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO A 474 |
| Chain | Residue |
| A | PHE54 |
| A | GLY63 |
| A | ALA65 |
| A | SER88 |
| A | GLY91 |
| A | ILE92 |
| A | ILE95 |
| A | ARG112 |
| A | ILE116 |
| site_id | IC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO D 462 |
| Chain | Residue |
| C | GLY102 |
| C | VAL104 |
| D | THR45 |
| D | ARG49 |
| D | TYR381 |
| site_id | IC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 475 |
| Chain | Residue |
| A | EDO13 |
| A | THR45 |
| A | ARG49 |
| A | TYR381 |
| A | EDO477 |
| B | GLY102 |
| site_id | JC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 464 |
| Chain | Residue |
| B | GLU67 |
| B | HIS132 |
| B | TYR343 |
| B | ILE411 |
| B | EDO465 |
| B | HOH575 |
| site_id | JC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 465 |
| Chain | Residue |
| B | GLU67 |
| B | ARG68 |
| B | TYR338 |
| B | EDO464 |
| site_id | JC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 476 |
| Chain | Residue |
| A | ASP290 |
| A | MSE433 |
| A | LYS451 |
| A | HOH655 |
| site_id | JC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO D 463 |
| Chain | Residue |
| C | VAL367 |
| C | TYR423 |
| C | TRP429 |
| D | GLU74 |
| site_id | JC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO D 464 |
| Chain | Residue |
| D | GLU67 |
| D | ARG68 |
| D | TYR338 |
| D | HOH497 |
| site_id | JC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 466 |
| Chain | Residue |
| A | HOH831 |
| B | HIS167 |
| B | GLN168 |
| B | PRO436 |
| site_id | JC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 467 |
| Chain | Residue |
| B | GLU225 |
| B | TRP281 |
| B | HOH515 |
| site_id | JC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO D 465 |
| Chain | Residue |
| A | HOH751 |
| D | TRP206 |
| D | GLU225 |
| D | TRP281 |
| D | HOH614 |
| site_id | JC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 477 |
| Chain | Residue |
| A | ARG49 |
| A | PHE388 |
| A | GLY389 |
| A | PRO390 |
| A | EDO475 |
| A | HOH946 |
