3EPS
The crystal structure of isocitrate dehydrogenase kinase/phosphatase from E. coli
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0004721 | molecular_function | phosphoprotein phosphatase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006006 | biological_process | glucose metabolic process |
| A | 0006097 | biological_process | glyoxylate cycle |
| A | 0006099 | biological_process | tricarboxylic acid cycle |
| A | 0008772 | molecular_function | [isocitrate dehydrogenase (NADP+)] kinase activity |
| A | 0016208 | molecular_function | AMP binding |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016310 | biological_process | phosphorylation |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016788 | molecular_function | hydrolase activity, acting on ester bonds |
| A | 0016791 | molecular_function | phosphatase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004674 | molecular_function | protein serine/threonine kinase activity |
| B | 0004721 | molecular_function | phosphoprotein phosphatase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006006 | biological_process | glucose metabolic process |
| B | 0006097 | biological_process | glyoxylate cycle |
| B | 0006099 | biological_process | tricarboxylic acid cycle |
| B | 0008772 | molecular_function | [isocitrate dehydrogenase (NADP+)] kinase activity |
| B | 0016208 | molecular_function | AMP binding |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016310 | biological_process | phosphorylation |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016788 | molecular_function | hydrolase activity, acting on ester bonds |
| B | 0016791 | molecular_function | phosphatase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE AMP A 1604 |
| Chain | Residue |
| A | ASN104 |
| A | ASN377 |
| A | SER105 |
| A | HIS113 |
| A | LEU116 |
| A | LYS291 |
| A | LYS294 |
| A | THR295 |
| A | TYR298 |
| A | GLU376 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE ATP A 1605 |
| Chain | Residue |
| A | PRO316 |
| A | GLY317 |
| A | ILE318 |
| A | VAL322 |
| A | MET323 |
| A | VAL325 |
| A | LYS336 |
| A | GLU416 |
| A | ARG417 |
| A | ARG418 |
| A | MET419 |
| A | PRO421 |
| A | ASN462 |
| A | TYR474 |
| A | ASP475 |
| A | ASP477 |
| A | GLU478 |
| A | MG1606 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG A 1606 |
| Chain | Residue |
| A | ASN462 |
| A | ASP475 |
| A | ATP1605 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE AMP B 1604 |
| Chain | Residue |
| B | ASN104 |
| B | SER105 |
| B | HIS113 |
| B | LEU116 |
| B | LYS291 |
| B | LYS294 |
| B | THR295 |
| B | TYR298 |
| B | GLU376 |
| B | ASN377 |
| B | HOH580 |
| site_id | AC5 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE ATP B 1605 |
| Chain | Residue |
| B | PRO316 |
| B | GLY317 |
| B | ILE318 |
| B | VAL322 |
| B | MET323 |
| B | VAL325 |
| B | VAL334 |
| B | LYS336 |
| B | GLU416 |
| B | ARG417 |
| B | ARG418 |
| B | MET419 |
| B | PRO421 |
| B | ASN462 |
| B | TYR474 |
| B | ASP475 |
| B | ASP477 |
| B | GLU478 |
| B | HOH594 |
| B | MG1606 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG B 1606 |
| Chain | Residue |
| B | ASN462 |
| B | ASP475 |
| B | ATP1605 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00747 |
| Chain | Residue | Details |
| A | ASP371 | |
| B | ASP371 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00747 |
| Chain | Residue | Details |
| A | ALA315 | |
| A | LYS336 | |
| B | ALA315 | |
| B | LYS336 |
