3EP3

Human AdoMetDC D174N mutant with no putrescine bound

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004014	molecular_function	adenosylmethionine decarboxylase activity
A	0006597	biological_process	spermine biosynthetic process
A	0008295	biological_process	spermidine biosynthetic process
B	0004014	molecular_function	adenosylmethionine decarboxylase activity
B	0008295	biological_process	spermidine biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PYR A 68

Chain	Residue
A	SER69
A	LYS80
A	THR81
A	HIS243
A	HOH500
B	LEU65

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE TRS A 368

Chain	Residue
B	PHE7
A	CYS226
A	THR245
A	GLU247

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PubMed","id":"1917972","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11583147","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"Proton donor; for catalytic activity","evidences":[{"source":"PubMed","id":"10029540","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11583147","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Active site: {"description":"Proton acceptor; for processing activity","evidences":[{"source":"PubMed","id":"11583147","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	3
Details	M-CSA 575

Chain	Residue	Details
B	LEU14	proton shuttle (general acid/base)

---