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3ELP

Structure of cystationine gamma lyase

Functional Information from GO Data
ChainGOidnamespacecontents
A0004123molecular_functioncystathionine gamma-lyase activity
A0005515molecular_functionprotein binding
A0005516molecular_functioncalmodulin binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006534biological_processcysteine metabolic process
A0006629biological_processlipid metabolic process
A0016829molecular_functionlyase activity
A0018272biological_processprotein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
A0019343biological_processcysteine biosynthetic process via cystathionine
A0019344biological_processcysteine biosynthetic process
A0019346biological_processtranssulfuration
A0030170molecular_functionpyridoxal phosphate binding
A0030968biological_processendoplasmic reticulum unfolded protein response
A0042802molecular_functionidentical protein binding
A0043066biological_processnegative regulation of apoptotic process
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0044524biological_processprotein sulfhydration
A0044540molecular_functionL-cystine L-cysteine-lyase (deaminating)
A0047982molecular_functionhomocysteine desulfhydrase activity
A0051289biological_processprotein homotetramerization
A0070062cellular_componentextracellular exosome
A0070814biological_processhydrogen sulfide biosynthetic process
A0080146molecular_functionL-cysteine desulfhydrase activity
A0098606molecular_functionselenocystathionine gamma-lyase activity
A1904831biological_processpositive regulation of aortic smooth muscle cell differentiation
A1990830biological_processcellular response to leukemia inhibitory factor
A2001234biological_processnegative regulation of apoptotic signaling pathway
B0004123molecular_functioncystathionine gamma-lyase activity
B0005515molecular_functionprotein binding
B0005516molecular_functioncalmodulin binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006534biological_processcysteine metabolic process
B0006629biological_processlipid metabolic process
B0016829molecular_functionlyase activity
B0018272biological_processprotein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
B0019343biological_processcysteine biosynthetic process via cystathionine
B0019344biological_processcysteine biosynthetic process
B0019346biological_processtranssulfuration
B0030170molecular_functionpyridoxal phosphate binding
B0030968biological_processendoplasmic reticulum unfolded protein response
B0042802molecular_functionidentical protein binding
B0043066biological_processnegative regulation of apoptotic process
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0044524biological_processprotein sulfhydration
B0044540molecular_functionL-cystine L-cysteine-lyase (deaminating)
B0047982molecular_functionhomocysteine desulfhydrase activity
B0051289biological_processprotein homotetramerization
B0070062cellular_componentextracellular exosome
B0070814biological_processhydrogen sulfide biosynthetic process
B0080146molecular_functionL-cysteine desulfhydrase activity
B0098606molecular_functionselenocystathionine gamma-lyase activity
B1904831biological_processpositive regulation of aortic smooth muscle cell differentiation
B1990830biological_processcellular response to leukemia inhibitory factor
B2001234biological_processnegative regulation of apoptotic signaling pathway
C0004123molecular_functioncystathionine gamma-lyase activity
C0005515molecular_functionprotein binding
C0005516molecular_functioncalmodulin binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006534biological_processcysteine metabolic process
C0006629biological_processlipid metabolic process
C0016829molecular_functionlyase activity
C0018272biological_processprotein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
C0019343biological_processcysteine biosynthetic process via cystathionine
C0019344biological_processcysteine biosynthetic process
C0019346biological_processtranssulfuration
C0030170molecular_functionpyridoxal phosphate binding
C0030968biological_processendoplasmic reticulum unfolded protein response
C0042802molecular_functionidentical protein binding
C0043066biological_processnegative regulation of apoptotic process
C0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
C0044524biological_processprotein sulfhydration
C0044540molecular_functionL-cystine L-cysteine-lyase (deaminating)
C0047982molecular_functionhomocysteine desulfhydrase activity
C0051289biological_processprotein homotetramerization
C0070062cellular_componentextracellular exosome
C0070814biological_processhydrogen sulfide biosynthetic process
C0080146molecular_functionL-cysteine desulfhydrase activity
C0098606molecular_functionselenocystathionine gamma-lyase activity
C1904831biological_processpositive regulation of aortic smooth muscle cell differentiation
C1990830biological_processcellular response to leukemia inhibitory factor
C2001234biological_processnegative regulation of apoptotic signaling pathway
D0004123molecular_functioncystathionine gamma-lyase activity
D0005515molecular_functionprotein binding
D0005516molecular_functioncalmodulin binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006534biological_processcysteine metabolic process
D0006629biological_processlipid metabolic process
D0016829molecular_functionlyase activity
D0018272biological_processprotein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
D0019343biological_processcysteine biosynthetic process via cystathionine
D0019344biological_processcysteine biosynthetic process
D0019346biological_processtranssulfuration
D0030170molecular_functionpyridoxal phosphate binding
D0030968biological_processendoplasmic reticulum unfolded protein response
D0042802molecular_functionidentical protein binding
D0043066biological_processnegative regulation of apoptotic process
D0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
D0044524biological_processprotein sulfhydration
D0044540molecular_functionL-cystine L-cysteine-lyase (deaminating)
D0047982molecular_functionhomocysteine desulfhydrase activity
D0051289biological_processprotein homotetramerization
D0070062cellular_componentextracellular exosome
D0070814biological_processhydrogen sulfide biosynthetic process
D0080146molecular_functionL-cysteine desulfhydrase activity
D0098606molecular_functionselenocystathionine gamma-lyase activity
D1904831biological_processpositive regulation of aortic smooth muscle cell differentiation
D1990830biological_processcellular response to leukemia inhibitory factor
D2001234biological_processnegative regulation of apoptotic signaling pathway
Functional Information from PROSITE/UniProt
site_idPS00868
Number of Residues15
DetailsCYS_MET_METAB_PP Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. DIsmySATKYMnGHS
ChainResidueDetails
BASP204-SER218

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues16
DetailsBINDING:
ChainResidueDetails
BARG62
CTYR114
CARG119
CGLU339
DARG62
DTYR114
DARG119
DGLU339
BTYR114
BARG119
BGLU339
AARG62
ATYR114
AARG119
AGLU339
CARG62

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000269|PubMed:19019829
ChainResidueDetails
BLYS212
ALYS212
CLYS212
DLYS212

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1b8g
ChainResidueDetails
BASP187
BTYR114

site_idCSA10
Number of Residues2
DetailsAnnotated By Reference To The Literature 1b8g
ChainResidueDetails
ALYS212
ASER209

site_idCSA11
Number of Residues2
DetailsAnnotated By Reference To The Literature 1b8g
ChainResidueDetails
CLYS212
CSER209

site_idCSA12
Number of Residues2
DetailsAnnotated By Reference To The Literature 1b8g
ChainResidueDetails
DLYS212
DSER209

site_idCSA13
Number of Residues3
DetailsAnnotated By Reference To The Literature 1b8g
ChainResidueDetails
BLYS212
BASP187
BPHE121

site_idCSA14
Number of Residues3
DetailsAnnotated By Reference To The Literature 1b8g
ChainResidueDetails
ALYS212
AASP187
APHE121

site_idCSA15
Number of Residues3
DetailsAnnotated By Reference To The Literature 1b8g
ChainResidueDetails
CLYS212
CASP187
CPHE121

site_idCSA16
Number of Residues3
DetailsAnnotated By Reference To The Literature 1b8g
ChainResidueDetails
DLYS212
DASP187
DPHE121

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1b8g
ChainResidueDetails
AASP187
ATYR114

site_idCSA3
Number of Residues2
DetailsAnnotated By Reference To The Literature 1b8g
ChainResidueDetails
CASP187
CTYR114

site_idCSA4
Number of Residues2
DetailsAnnotated By Reference To The Literature 1b8g
ChainResidueDetails
DASP187
DTYR114

site_idCSA5
Number of Residues3
DetailsAnnotated By Reference To The Literature 1b8g
ChainResidueDetails
BLYS212
BASP187
BTYR114

site_idCSA6
Number of Residues3
DetailsAnnotated By Reference To The Literature 1b8g
ChainResidueDetails
ALYS212
AASP187
ATYR114

site_idCSA7
Number of Residues3
DetailsAnnotated By Reference To The Literature 1b8g
ChainResidueDetails
CLYS212
CASP187
CTYR114

site_idCSA8
Number of Residues3
DetailsAnnotated By Reference To The Literature 1b8g
ChainResidueDetails
DLYS212
DASP187
DTYR114

site_idCSA9
Number of Residues2
DetailsAnnotated By Reference To The Literature 1b8g
ChainResidueDetails
BLYS212
BSER209

223166

PDB entries from 2024-07-31

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