3EGV

Ribosomal protein L11 methyltransferase (PrmA) in complex with trimethylated ribosomal protein L11

Replaces:  3CJU

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0006479	biological_process	protein methylation
A	0008168	molecular_function	methyltransferase activity
A	0008276	molecular_function	protein methyltransferase activity
A	0016279	molecular_function	protein-lysine N-methyltransferase activity
A	0016740	molecular_function	transferase activity
A	0032259	biological_process	methylation
B	0003723	molecular_function	RNA binding
B	0003735	molecular_function	structural constituent of ribosome
B	0005840	cellular_component	ribosome
B	0006412	biological_process	translation
B	0015934	cellular_component	large ribosomal subunit
B	0019843	molecular_function	rRNA binding
B	0022625	cellular_component	cytosolic large ribosomal subunit
B	0070180	molecular_function	large ribosomal subunit rRNA binding
B	1990904	cellular_component	ribonucleoprotein complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	BINDING SITE FOR RESIDUE SAH A 301

Chain	Residue
A	PHE99
A	ASP151
A	SER175
A	ASN191
A	LEU192
A	LEU196
A	HOH572
A	HOH721
A	HOH723
A	HOH732
A	HOH738
A	GLY100
A	HOH739
A	HOH746
B	4MM1
A	THR107
A	GLY128
A	THR129
A	GLY130
A	LEU134
A	ASP149
A	ILE150

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 302

Chain	Residue
A	PRO120
A	GLU159
A	ARG170
A	PHE171
A	HOH503
A	HOH628
A	HOH656
A	HOH668

---

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL A 303

Chain	Residue
A	ALA115
A	ARG116
A	LEU118
A	LYS123
A	ALA145
A	LEU146
A	ARG170
A	PHE182
A	HOH612
A	HOH614
A	HOH728

---

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 304

Chain	Residue
A	ARG116
A	HIS117
A	GLY183
A	PRO184
A	ASP186
A	VAL209
A	GLU240
A	HOH532
A	HOH607
A	HOH609

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 305

Chain	Residue
A	ARG65
A	LYS68
A	PRO69
A	HIS82
A	THR83
A	HOH745
A	HOH755

---

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 306

Chain	Residue
A	HOH465

---

Functional Information from PROSITE/UniProt

site_id	PS00359
Number of Residues	16
Details	RIBOSOMAL_L11 Ribosomal protein L11 signature. RmIaGSarSMGvEVvG

Chain	Residue	Details
B	ARG125-GLY140

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00735","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17215866","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18611379","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"OCT-2007","submissionDatabase":"PDB data bank","title":"Crystal structure of ribosomal protein L11 methyltransferase from Thermus thermophilus.","authors":["Kaminishi T.","Sakai H.","Takemoto-Hori C.","Terada T.","Nakagawa N.","Maoka N.","Kuramitsu S.","Shirouzu M.","Yokoyama S."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17215866","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18611379","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"OCT-2007","submissionDatabase":"PDB data bank","title":"Crystal structure of ribosomal protein L11 methyltransferase from Thermus thermophilus.","authors":["Kaminishi T.","Sakai H.","Takemoto-Hori C.","Terada T.","Nakagawa N.","Maoka N.","Kuramitsu S.","Shirouzu M.","Yokoyama S."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"N6,N6,N6-trimethyllysine","evidences":[{"source":"PubMed","id":"10333296","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"N6,N6,N6-trimethyllysine","evidences":[{"source":"PubMed","id":"18611379","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3EGV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"N6,N6,N6-trimethyllysine","evidences":[{"source":"UniProtKB","id":"P0A7J7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1qam

Chain	Residue	Details
A	ASP149
A	ASN191
A	GLY128

---