3EEI
Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from neisseria meningitidis in complex with methylthio-immucillin-A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0008782 | molecular_function | adenosylhomocysteine nucleosidase activity |
| A | 0008930 | molecular_function | methylthioadenosine nucleosidase activity |
| A | 0009116 | biological_process | nucleoside metabolic process |
| A | 0009164 | biological_process | nucleoside catabolic process |
| A | 0019509 | biological_process | obsolete L-methionine salvage from methylthioadenosine |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0008782 | molecular_function | adenosylhomocysteine nucleosidase activity |
| B | 0008930 | molecular_function | methylthioadenosine nucleosidase activity |
| B | 0009116 | biological_process | nucleoside metabolic process |
| B | 0009164 | biological_process | nucleoside catabolic process |
| B | 0019509 | biological_process | obsolete L-methionine salvage from methylthioadenosine |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE MTM A 234 |
| Chain | Residue |
| A | ALA11 |
| A | GLU178 |
| A | ARG197 |
| A | SER200 |
| A | ASP201 |
| A | ALA203 |
| A | PHE211 |
| A | HOH253 |
| A | SER79 |
| A | ALA80 |
| A | GLY81 |
| A | ARG154 |
| A | PHE155 |
| A | VAL156 |
| A | GLU176 |
| A | MET177 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE MTM B 234 |
| Chain | Residue |
| B | ALA11 |
| B | ILE53 |
| B | SER79 |
| B | ALA80 |
| B | GLY81 |
| B | ARG154 |
| B | PHE155 |
| B | VAL156 |
| B | GLU176 |
| B | MET177 |
| B | GLU178 |
| B | ARG197 |
| B | SER200 |
| B | ASP201 |
| B | ALA203 |
| B | PHE211 |
| B | HOH256 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a69 |
| Chain | Residue | Details |
| A | ASP201 | |
| A | PHE214 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a69 |
| Chain | Residue | Details |
| B | ASP201 | |
| B | PHE214 |
