Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACE A 201 |
| Chain | Residue |
| A | ALA1 |
| A | ALA2 |
| A | GLU103 |
| A | ARG106 |
| A | SER136 |
| A | GLN189 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN A 210 |
| Chain | Residue |
| A | HIS92 |
| A | HIS96 |
| A | HIS102 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 211 |
| Chain | Residue |
| A | GLU103 |
| A | GLN189 |
| A | HOH221 |
| A | HOH224 |
| A | HOH228 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DMS A 212 |
| Chain | Residue |
| A | LYS39 |
| A | HIS40 |
| A | ARG106 |
| A | ASP108 |
| A | GLU139 |
| A | HOH290 |
| A | HOH581 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS A 213 |
| Chain | Residue |
| A | ARG35 |
| A | LYS39 |
| A | LYS192 |
| A | HOH462 |
| A | HOH594 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE DMS A 214 |
| Chain | Residue |
| A | CYS64 |
| A | HIS92 |
| A | GLU93 |
| A | HIS96 |
| A | HIS102 |
| A | HOH297 |
| A | HOH306 |
| A | HOH314 |
| A | HOH604 |
| A | HOH609 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS A 215 |
| Chain | Residue |
| A | ASP50 |
| A | ARG176 |
| A | THR180 |
| A | HOH536 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS A 216 |
| Chain | Residue |
| A | ARG31 |
| A | GLU38 |
| A | PHE45 |
| A | HOH546 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. IVVHELGHVV |
| Chain | Residue | Details |
| A | ILE89-VAL98 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 199 |
| Details | Domain: {"description":"Peptidase M12A","evidences":[{"source":"PROSITE-ProRule","id":"PRU01211","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01211","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18824173","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01211","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18824173","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ast |
| Chain | Residue | Details |
| A | TYR149 | |
| A | GLU93 | |
