3EAM
An open-pore structure of a bacterial pentameric ligand-gated ion channel
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004888 | molecular_function | transmembrane signaling receptor activity |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0004888 | molecular_function | transmembrane signaling receptor activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| C | 0004888 | molecular_function | transmembrane signaling receptor activity |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0034220 | biological_process | monoatomic ion transmembrane transport |
| D | 0004888 | molecular_function | transmembrane signaling receptor activity |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0034220 | biological_process | monoatomic ion transmembrane transport |
| E | 0004888 | molecular_function | transmembrane signaling receptor activity |
| E | 0005216 | molecular_function | monoatomic ion channel activity |
| E | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| E | 0006811 | biological_process | monoatomic ion transport |
| E | 0016020 | cellular_component | membrane |
| E | 0034220 | biological_process | monoatomic ion transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE LMT A 501 |
| Chain | Residue |
| A | ILE240 |
| A | THR244 |
| A | ASN245 |
| B | LYS33 |
| B | THR244 |
| B | LMT501 |
| E | ALA237 |
| E | LMT602 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PC1 A 602 |
| Chain | Residue |
| A | TYR194 |
| A | LEU203 |
| A | TYR254 |
| A | ASN307 |
| A | PHE121 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PC1 A 603 |
| Chain | Residue |
| A | PHE265 |
| A | ARG287 |
| A | ILE291 |
| A | ALA294 |
| A | PHE299 |
| A | PC1601 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PC1 A 601 |
| Chain | Residue |
| A | VAL275 |
| A | TYR278 |
| A | GLU282 |
| A | PC1603 |
| E | TRP217 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PC1 B 601 |
| Chain | Residue |
| A | TRP217 |
| A | LEU304 |
| B | TYR278 |
| B | GLU282 |
| B | ARG287 |
| B | PC1603 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE LMT B 501 |
| Chain | Residue |
| A | ALA237 |
| A | LMT501 |
| B | ILE240 |
| B | THR244 |
| B | ASN245 |
| C | LYS33 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PC1 B 602 |
| Chain | Residue |
| B | TYR194 |
| B | ILE198 |
| B | TYR254 |
| B | ASN307 |
| B | PHE315 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PC1 B 603 |
| Chain | Residue |
| B | ILE291 |
| B | ALA294 |
| B | PHE299 |
| B | PC1601 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE LMT C 502 |
| Chain | Residue |
| A | SER230 |
| C | SER230 |
| C | ILE233 |
| C | LMT501 |
| E | SER230 |
| E | LMT602 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PC1 C 601 |
| Chain | Residue |
| B | TRP217 |
| C | TYR278 |
| C | LEU279 |
| C | GLU282 |
| C | GLN284 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE LMT C 501 |
| Chain | Residue |
| B | ALA237 |
| C | ILE240 |
| C | THR244 |
| C | ASN245 |
| C | LMT502 |
| D | LYS33 |
| E | LMT501 |
| site_id | BC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PC1 C 602 |
| Chain | Residue |
| C | SER191 |
| C | TYR194 |
| C | ILE198 |
| C | LEU203 |
| C | LEU206 |
| C | TYR254 |
| C | ASN307 |
| C | PHE315 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PC1 C 603 |
| Chain | Residue |
| C | PHE265 |
| C | ARG287 |
| C | ALA294 |
| C | PHE299 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PC1 D 601 |
| Chain | Residue |
| C | TRP217 |
| D | TYR278 |
| D | GLU282 |
| D | ARG287 |
| D | PC1603 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PC1 D 602 |
| Chain | Residue |
| D | TYR194 |
| D | TYR254 |
| D | ASN307 |
| D | PHE315 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PC1 D 603 |
| Chain | Residue |
| D | ARG287 |
| D | ALA294 |
| D | PHE299 |
| D | PC1601 |
| site_id | BC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE LMT E 501 |
| Chain | Residue |
| C | LMT501 |
| D | ALA237 |
| D | ILE240 |
| D | LEU241 |
| D | THR244 |
| D | ASN245 |
| E | LYS33 |
| E | THR244 |
| E | LMT602 |
| site_id | BC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE LMT E 602 |
| Chain | Residue |
| C | LMT502 |
| E | ASP31 |
| E | ILE240 |
| E | THR244 |
| E | ASN245 |
| E | LMT501 |
| A | LYS33 |
| A | LMT501 |
| site_id | CC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PC1 E 601 |
| Chain | Residue |
| D | PHE210 |
| D | TRP217 |
| E | TYR278 |
| E | GLU282 |
| E | GLN284 |
| E | ARG287 |
| E | PC1604 |
| site_id | CC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PC1 E 603 |
| Chain | Residue |
| E | ARG118 |
| E | SER191 |
| E | TYR194 |
| E | TYR254 |
| E | ILE258 |
| E | ASN307 |
| site_id | CC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PC1 E 604 |
| Chain | Residue |
| E | ARG287 |
| E | ALA294 |
| E | ALA298 |
| E | PHE299 |
| E | PC1601 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 990 |
| Details | TOPO_DOM: Periplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | GLN2-GLN193 | |
| E | ASN245-MET252 | |
| A | ASN245-MET252 | |
| B | GLN2-GLN193 | |
| B | ASN245-MET252 | |
| C | GLN2-GLN193 | |
| C | ASN245-MET252 | |
| D | GLN2-GLN193 | |
| D | ASN245-MET252 | |
| E | GLN2-GLN193 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 530 |
| Details | TRANSMEM: Helical |
| Chain | Residue | Details |
| A | TYR194-PHE216 | |
| C | SER220-THR244 | |
| C | THR253-VAL281 | |
| C | PRO285-PHE317 | |
| D | TYR194-PHE216 | |
| D | SER220-THR244 | |
| D | THR253-VAL281 | |
| D | PRO285-PHE317 | |
| E | TYR194-PHE216 | |
| E | SER220-THR244 | |
| E | THR253-VAL281 | |
| A | SER220-THR244 | |
| E | PRO285-PHE317 | |
| A | THR253-VAL281 | |
| A | PRO285-PHE317 | |
| B | TYR194-PHE216 | |
| B | SER220-THR244 | |
| B | THR253-VAL281 | |
| B | PRO285-PHE317 | |
| C | TYR194-PHE216 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | TRP217-THR219 | |
| E | GLU282-GLN284 | |
| A | GLU282-GLN284 | |
| B | TRP217-THR219 | |
| B | GLU282-GLN284 | |
| C | TRP217-THR219 | |
| C | GLU282-GLN284 | |
| D | TRP217-THR219 | |
| D | GLU282-GLN284 | |
| E | TRP217-THR219 |
