Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3EAM

An open-pore structure of a bacterial pentameric ligand-gated ion channel

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE LMT A 501

Chain	Residue
A	ILE240
A	THR244
A	ASN245
B	LYS33
B	THR244
B	LMT501
E	ALA237
E	LMT602

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PC1 A 602

Chain	Residue
A	TYR194
A	LEU203
A	TYR254
A	ASN307
A	PHE121

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PC1 A 603

Chain	Residue
A	PHE265
A	ARG287
A	ILE291
A	ALA294
A	PHE299
A	PC1601

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PC1 A 601

Chain	Residue
A	VAL275
A	TYR278
A	GLU282
A	PC1603
E	TRP217

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PC1 B 601

Chain	Residue
A	TRP217
A	LEU304
B	TYR278
B	GLU282
B	ARG287
B	PC1603

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE LMT B 501

Chain	Residue
A	ALA237
A	LMT501
B	ILE240
B	THR244
B	ASN245
C	LYS33

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PC1 B 602

Chain	Residue
B	TYR194
B	ILE198
B	TYR254
B	ASN307
B	PHE315

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PC1 B 603

Chain	Residue
B	ILE291
B	ALA294
B	PHE299
B	PC1601

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE LMT C 502

Chain	Residue
A	SER230
C	SER230
C	ILE233
C	LMT501
E	SER230
E	LMT602

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PC1 C 601

Chain	Residue
B	TRP217
C	TYR278
C	LEU279
C	GLU282
C	GLN284

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE LMT C 501

Chain	Residue
B	ALA237
C	ILE240
C	THR244
C	ASN245
C	LMT502
D	LYS33
E	LMT501

site_id	BC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PC1 C 602

Chain	Residue
C	SER191
C	TYR194
C	ILE198
C	LEU203
C	LEU206
C	TYR254
C	ASN307
C	PHE315

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PC1 C 603

Chain	Residue
C	PHE265
C	ARG287
C	ALA294
C	PHE299

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PC1 D 601

Chain	Residue
C	TRP217
D	TYR278
D	GLU282
D	ARG287
D	PC1603

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PC1 D 602

Chain	Residue
D	TYR194
D	TYR254
D	ASN307
D	PHE315

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PC1 D 603

Chain	Residue
D	ARG287
D	ALA294
D	PHE299
D	PC1601

site_id	BC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE LMT E 501

Chain	Residue
C	LMT501
D	ALA237
D	ILE240
D	LEU241
D	THR244
D	ASN245
E	LYS33
E	THR244
E	LMT602

site_id	BC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE LMT E 602

Chain	Residue
C	LMT502
E	ASP31
E	ILE240
E	THR244
E	ASN245
E	LMT501
A	LYS33
A	LMT501

site_id	CC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PC1 E 601

Chain	Residue
D	PHE210
D	TRP217
E	TYR278
E	GLU282
E	GLN284
E	ARG287
E	PC1604

site_id	CC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PC1 E 603

Chain	Residue
E	ARG118
E	SER191
E	TYR194
E	TYR254
E	ILE258
E	ASN307

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PC1 E 604

Chain	Residue
E	ARG287
E	ALA294
E	ALA298
E	PHE299
E	PC1601

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	370
Details	Transmembrane: {"description":"Helical"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	20
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	35
Details	Topological domain: {"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)