3E73
Crystal Structure of Human LanCL1 complexed with GSH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004364 | molecular_function | glutathione transferase activity |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0017124 | molecular_function | SH3 domain binding |
| A | 0031179 | biological_process | peptide modification |
| A | 0043295 | molecular_function | glutathione binding |
| A | 0050750 | molecular_function | low-density lipoprotein particle receptor binding |
| A | 1990748 | biological_process | cellular detoxification |
| B | 0004364 | molecular_function | glutathione transferase activity |
| B | 0004930 | molecular_function | G protein-coupled receptor activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0017124 | molecular_function | SH3 domain binding |
| B | 0031179 | biological_process | peptide modification |
| B | 0043295 | molecular_function | glutathione binding |
| B | 0050750 | molecular_function | low-density lipoprotein particle receptor binding |
| B | 1990748 | biological_process | cellular detoxification |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 501 |
| Chain | Residue |
| A | CYS276 |
| A | CYS322 |
| A | HIS323 |
| A | GSH502 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GSH A 502 |
| Chain | Residue |
| A | HIS323 |
| A | ARG364 |
| A | PRO366 |
| A | ASP367 |
| A | GLU374 |
| A | ZN501 |
| A | ARG4 |
| A | HIS274 |
| A | HIS277 |
| A | LYS317 |
| A | CYS322 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 502 |
| Chain | Residue |
| B | CYS276 |
| B | CYS322 |
| B | HIS323 |
| B | GSH503 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GSH B 503 |
| Chain | Residue |
| B | ARG4 |
| B | HIS274 |
| B | HIS277 |
| B | LYS317 |
| B | CYS322 |
| B | HIS323 |
| B | ARG364 |
| B | PRO366 |
| B | ASP367 |
| B | GLU374 |
| B | ZN502 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19528316","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
