3E73

Crystal Structure of Human LanCL1 complexed with GSH

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004364	molecular_function	glutathione transferase activity
A	0004930	molecular_function	G protein-coupled receptor activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0005975	biological_process	carbohydrate metabolic process
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0008270	molecular_function	zinc ion binding
A	0016020	cellular_component	membrane
A	0016740	molecular_function	transferase activity
A	0017124	molecular_function	SH3 domain binding
A	0031179	biological_process	peptide modification
A	0043295	molecular_function	glutathione binding
A	0046872	molecular_function	metal ion binding
A	0050750	molecular_function	low-density lipoprotein particle receptor binding
A	1990748	biological_process	cellular detoxification
B	0004364	molecular_function	glutathione transferase activity
B	0004930	molecular_function	G protein-coupled receptor activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005886	cellular_component	plasma membrane
B	0005975	biological_process	carbohydrate metabolic process
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0008270	molecular_function	zinc ion binding
B	0016020	cellular_component	membrane
B	0016740	molecular_function	transferase activity
B	0017124	molecular_function	SH3 domain binding
B	0031179	biological_process	peptide modification
B	0043295	molecular_function	glutathione binding
B	0046872	molecular_function	metal ion binding
B	0050750	molecular_function	low-density lipoprotein particle receptor binding
B	1990748	biological_process	cellular detoxification

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 501

Chain	Residue
A	CYS276
A	CYS322
A	HIS323
A	GSH502

---

site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GSH A 502

Chain	Residue
A	HIS323
A	ARG364
A	PRO366
A	ASP367
A	GLU374
A	ZN501
A	ARG4
A	HIS274
A	HIS277
A	LYS317
A	CYS322

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 502

Chain	Residue
B	CYS276
B	CYS322
B	HIS323
B	GSH503

---

site_id	AC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GSH B 503

Chain	Residue
B	ARG4
B	HIS274
B	HIS277
B	LYS317
B	CYS322
B	HIS323
B	ARG364
B	PRO366
B	ASP367
B	GLU374
B	ZN502

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19528316","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---