3E6A

Crystal structure and Functional Analysis of Glyceraldehyde-3-phosphate Dehydrogenase from Oryza Sativa

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006006	biological_process	glucose metabolic process
A	0006096	biological_process	glycolytic process
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A	0032991	cellular_component	protein-containing complex
A	0042301	molecular_function	phosphate ion binding
A	0050661	molecular_function	NADP binding
A	0051287	molecular_function	NAD binding
A	0070403	molecular_function	NAD+ binding
B	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006006	biological_process	glucose metabolic process
B	0006096	biological_process	glycolytic process
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0032991	cellular_component	protein-containing complex
B	0042301	molecular_function	phosphate ion binding
B	0050661	molecular_function	NADP binding
B	0051287	molecular_function	NAD binding
B	0070403	molecular_function	NAD+ binding
C	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006006	biological_process	glucose metabolic process
C	0006096	biological_process	glycolytic process
C	0016491	molecular_function	oxidoreductase activity
C	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C	0032991	cellular_component	protein-containing complex
C	0042301	molecular_function	phosphate ion binding
C	0050661	molecular_function	NADP binding
C	0051287	molecular_function	NAD binding
C	0070403	molecular_function	NAD+ binding
O	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0006006	biological_process	glucose metabolic process
O	0006096	biological_process	glycolytic process
O	0016491	molecular_function	oxidoreductase activity
O	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
O	0032991	cellular_component	protein-containing complex
O	0042301	molecular_function	phosphate ion binding
O	0050661	molecular_function	NADP binding
O	0051287	molecular_function	NAD binding
O	0070403	molecular_function	NAD+ binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 O6920

Chain	Residue
O	THR184
O	THR186
O	ARG236

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 O6921

Chain	Residue
O	SER153
O	THR155
O	THR156
O	THR213
O	GLY214
O	ALA215

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A6922

Chain	Residue
A	THR184
A	THR186
A	ARG236

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A6923

Chain	Residue
A	SER153
A	THR155
A	THR213
A	ALA215

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B6924

Chain	Residue
B	SER153
B	THR155
B	THR213
B	ALA215

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B6925

Chain	Residue
B	THR184
B	THR186
B	ARG236

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C6926

Chain	Residue
C	SER153
C	THR155
C	THR213
C	GLY214
C	ALA215

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C6927

Chain	Residue
C	THR184
C	THR186
C	ARG236

---

Functional Information from PROSITE/UniProt

site_id	PS00071
Number of Residues	8
Details	GAPDH Glyceraldehyde 3-phosphate dehydrogenase active site. ASCTTNcL

Chain	Residue	Details
O	ALA152-LEU159

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PROSITE-ProRule","id":"PRU10009","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22903596","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Site: {"description":"Activates thiol group during catalysis","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1szj

Chain	Residue	Details
O	HIS181
O	CYS154

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1szj

Chain	Residue	Details
A	HIS181
A	CYS154

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1szj

Chain	Residue	Details
B	HIS181
B	CYS154

---

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1szj

Chain	Residue	Details
C	HIS181
C	CYS154

---