Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004601 | molecular_function | peroxidase activity |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0020037 | molecular_function | heme binding |
| A | 0034599 | biological_process | cellular response to oxidative stress |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE HEM A 296 |
| Chain | Residue |
| A | PRO37 |
| A | HIS168 |
| A | GLY171 |
| A | LYS172 |
| A | THR173 |
| A | HIS174 |
| A | ARG177 |
| A | SER178 |
| A | LEU225 |
| A | THR227 |
| A | HOH1054 |
| A | ARG41 |
| A | HOH1126 |
| A | HOH1215 |
| A | HOH1370 |
| A | TRP44 |
| A | PRO138 |
| A | ASP139 |
| A | ALA140 |
| A | LEU164 |
| A | MET165 |
| A | ALA167 |
Functional Information from PROSITE/UniProt
| site_id | PS00435 |
| Number of Residues | 11 |
| Details | PEROXIDASE_1 Peroxidases proximal heme-ligand signature. EVVALMGAHAL |
| Chain | Residue | Details |
| A | GLU160-LEU170 | |
| site_id | PS00436 |
| Number of Residues | 12 |
| Details | PEROXIDASE_2 Peroxidases active site signature. GPvlVRLaWHTS |
| Chain | Residue | Details |
| A | GLY36-SER47 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor"} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Tryptophan radical intermediate","evidences":[{"source":"PubMed","id":"2851317","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {"description":"axial binding residue","evidences":[{"source":"PROSITE-ProRule","id":"PRU00297","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"7703247","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Site: {"description":"Transition state stabilizer"} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"7703247","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1APX","evidenceCode":"ECO:0007744"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1apx |
| Chain | Residue | Details |
| A | ASN75 | |
| A | HIS45 | |
| A | ARG41 | |
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 709 |
| Chain | Residue | Details |
| A | ARG41 | electrostatic stabiliser |
| A | HIS45 | electrostatic stabiliser, proton acceptor, proton donor |
| A | PHE184 | single electron acceptor, single electron donor |
| site_id | MCSA2 |
| Number of Residues | 5 |
| Details | M-CSA 399 |
| Chain | Residue | Details |
| A | ARG41 | transition state stabiliser |
| A | HIS45 | proton shuttle (general acid/base) |
| A | HIS168 | activator, metal ligand |
| A | PHE184 | radical stabiliser |
| A | ASP228 | activator |
