3DZH

Crystal structure of human CD38 extracellular domain, GTP complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0061809	molecular_function	NAD+ nucleosidase activity, cyclic ADP-ribose generating
B	0061809	molecular_function	NAD+ nucleosidase activity, cyclic ADP-ribose generating

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GTP A 301

Chain	Residue
A	TRP125
A	HOH314
A	HOH447
A	HOH471
A	HOH500
A	LEU145
A	GLU146
A	ASP155
A	TRP176
A	ARG177
A	TRP189
A	SER193
A	THR221

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site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GTP B 301

Chain	Residue
B	TRP125
B	GLU146
B	ASP155
B	TRP189
B	THR221
B	HOH303
B	HOH333
B	HOH349
B	HOH403
B	HOH417
B	HOH447

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"evidences":[{"source":"PubMed","id":"7961800","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1r16

Chain	Residue	Details
A	GLU226
A	GLU146

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1r16

Chain	Residue	Details
B	GLU226
B	GLU146

---