3DZ2

Human AdoMetDC with 5'-[(3-aminopropyl)methylamino]-5'deoxy-8-methyladenosine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004014	molecular_function	adenosylmethionine decarboxylase activity
A	0006597	biological_process	spermine biosynthetic process
A	0008295	biological_process	spermidine biosynthetic process
B	0004014	molecular_function	adenosylmethionine decarboxylase activity
B	0008295	biological_process	spermidine biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PYR A 68

Chain	Residue
A	SER69
A	LYS80
A	THR81
A	HIS243
B	LEU65

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site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PUT B 350

Chain	Residue
B	LEU13
B	GLU15
B	HOH363
B	HOH381
A	PHE111
A	ASP174
A	THR176
A	HOH391

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site_id	AC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE A8M A 368

Chain	Residue
A	CYS82
A	PHE223
A	ASN224
A	CYS226
A	GLY227
A	TYR228
A	SER229
A	HIS243
A	ILE244
A	THR245
A	PRO246
A	GLU247
A	HOH389
B	PHE7
B	GLU11
B	SER66
B	GLU67

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor; for catalytic activity => ECO:0000269|PubMed:10029540, ECO:0000269|PubMed:11583147

Chain	Residue	Details
A	CYS82
B	GLU11

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site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: Proton acceptor; for processing activity => ECO:0000269|PubMed:11583147

Chain	Residue	Details
A	SER229
A	HIS243

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:11583147

Chain	Residue	Details
A	PHE223
A	GLU247

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
A	SER298

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	3
Details	M-CSA 575

Chain	Residue	Details
A	CYS82	proton shuttle (general acid/base)
A	SER229
A	HIS243

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