3DYH
T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-721
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004161 | molecular_function | dimethylallyltranstransferase activity |
| A | 0004337 | molecular_function | geranyltranstransferase activity |
| A | 0004659 | molecular_function | prenyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| A | 0045337 | biological_process | farnesyl diphosphate biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004161 | molecular_function | dimethylallyltranstransferase activity |
| B | 0004337 | molecular_function | geranyltranstransferase activity |
| B | 0004659 | molecular_function | prenyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| B | 0045337 | biological_process | farnesyl diphosphate biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG A 3002 |
| Chain | Residue |
| A | ASP103 |
| A | ASP107 |
| A | HOH3022 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 3003 |
| Chain | Residue |
| A | ASP255 |
| A | HOH3005 |
| A | HOH3026 |
| A | HOH3048 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 3004 |
| Chain | Residue |
| A | HOH3006 |
| A | HOH3017 |
| A | HOH3102 |
| A | ASP103 |
| A | ASP107 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 4002 |
| Chain | Residue |
| B | ASP103 |
| B | ASP107 |
| B | HOH4006 |
| B | HOH4008 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 4003 |
| Chain | Residue |
| B | ASP255 |
| B | HOH4039 |
| B | HOH4041 |
| B | HOH4179 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 4004 |
| Chain | Residue |
| B | ASP103 |
| B | ASP107 |
| B | HOH4020 |
| B | HOH4021 |
| B | HOH4117 |
| site_id | AC7 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE 721 A 3001 |
| Chain | Residue |
| A | TYR99 |
| A | ASP103 |
| A | ASP107 |
| A | ARG112 |
| A | THR168 |
| A | GLN172 |
| A | LYS212 |
| A | THR213 |
| A | ASP255 |
| A | LYS269 |
| A | HOH3005 |
| A | HOH3006 |
| A | HOH3017 |
| A | HOH3022 |
| A | HOH3024 |
| A | HOH3026 |
| A | HOH3047 |
| A | HOH3048 |
| B | ASN131 |
| B | LEU134 |
| site_id | AC8 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE 721 B 4001 |
| Chain | Residue |
| A | ASN131 |
| A | LEU134 |
| B | TYR99 |
| B | ASP103 |
| B | ASP107 |
| B | ARG112 |
| B | THR168 |
| B | GLN172 |
| B | LYS212 |
| B | THR213 |
| B | ASP255 |
| B | LYS269 |
| B | HOH4006 |
| B | HOH4008 |
| B | HOH4020 |
| B | HOH4021 |
| B | HOH4032 |
| B | HOH4041 |
| B | HOH4044 |
| B | HOH4179 |
Functional Information from PROSITE/UniProt
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1fps |
| Chain | Residue | Details |
| A | PHE251 | |
| A | ARG112 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1fps |
| Chain | Residue | Details |
| B | PHE251 | |
| B | ARG112 |
