3DYD
Human Tyrosine Aminotransferase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004838 | molecular_function | L-tyrosine-2-oxoglutarate transaminase activity |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0008483 | molecular_function | transaminase activity |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0009072 | biological_process | aromatic amino acid metabolic process |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004838 | molecular_function | L-tyrosine-2-oxoglutarate transaminase activity |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0008483 | molecular_function | transaminase activity |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0009072 | biological_process | aromatic amino acid metabolic process |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE PLP A 500 |
| Chain | Residue |
| A | GLY143 |
| A | LYS280 |
| A | ARG288 |
| A | HOH535 |
| A | HOH548 |
| B | TYR109 |
| A | CYS144 |
| A | SER145 |
| A | ASN215 |
| A | ASN219 |
| A | ASP247 |
| A | ILE249 |
| A | TYR250 |
| A | ALA279 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE PLP B 500 |
| Chain | Residue |
| A | TYR109 |
| B | GLY143 |
| B | CYS144 |
| B | SER145 |
| B | PHE169 |
| B | ASN215 |
| B | ASN219 |
| B | ASP247 |
| B | ILE249 |
| B | TYR250 |
| B | ALA279 |
| B | LYS280 |
| B | ARG288 |
| B | HOH552 |
| B | HOH555 |
Functional Information from PROSITE/UniProt
| site_id | PS00105 |
| Number of Residues | 14 |
| Details | AA_TRANSFER_CLASS_1 Aminotransferases class-I pyridoxal-phosphate attachment site. GLAKrwLVpGWRLG |
| Chain | Residue | Details |
| A | GLY277-GLY290 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"AUG-2008","submissionDatabase":"PDB data bank","title":"Human tyrosine aminotransferase.","authoringGroup":["Structural genomics consortium (SGC)"]}},{"source":"PDB","id":"3DYD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ay4 |
| Chain | Residue | Details |
| A | LYS280 | |
| A | PHE169 | |
| A | ASP247 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ay4 |
| Chain | Residue | Details |
| B | LYS280 | |
| B | PHE169 | |
| B | ASP247 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ay4 |
| Chain | Residue | Details |
| A | PHE169 | |
| A | ASP247 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ay4 |
| Chain | Residue | Details |
| B | PHE169 | |
| B | ASP247 |
