3DY8

Human Phosphodiesterase 9 in complex with product 5'-GMP (E+P complex)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
A	0007165	biological_process	signal transduction
A	0008081	molecular_function	phosphoric diester hydrolase activity
B	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
B	0007165	biological_process	signal transduction
B	0008081	molecular_function	phosphoric diester hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN A 901

Chain	Residue
A	HIS256
A	HIS292
A	ASP293
A	ASP402
A	5GP900
A	HOH1138
A	HOH1139

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG A 902

Chain	Residue
A	HOH1135
A	HOH1136
A	HOH1137
A	HOH1138
A	HOH1140
A	ASP293
A	5GP900

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN B 901

Chain	Residue
B	FMT1
B	HIS256
B	HIS292
B	ASP293
B	ASP402
B	HOH1265

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 902

Chain	Residue
B	ASP293
B	HOH1265
B	HOH1266
B	HOH1267
B	HOH1268
B	HOH1269

---

site_id	AC5
Number of Residues	21
Details	BINDING SITE FOR RESIDUE 5GP A 900

Chain	Residue
A	HIS252
A	HIS256
A	ASP293
A	MET365
A	ASP402
A	ILE403
A	LEU420
A	TYR424
A	ALA452
A	GLN453
A	PHE456
A	MN901
A	MG902
A	HOH914
A	HOH915
A	HOH917
A	HOH951
A	HOH1138
A	HOH1139
A	HOH1140
A	HOH1141

---

site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE IBM B 900

Chain	Residue
A	ALA499
B	FMT1
B	LEU420
B	TYR424
B	ALA452
B	GLN453
B	PHE456
B	HOH1066
B	HOH1104
B	HOH1121

---

site_id	AC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE FMT B 1

Chain	Residue
B	PHE251
B	HIS252
B	HIS256
B	ASP293
B	ASP402
B	IBM900
B	MN901
B	HOH1066
B	HOH1258
B	HOH1265

---

Functional Information from PROSITE/UniProt

site_id	PS00126
Number of Residues	12
Details	PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHpGynNtY

Chain	Residue	Details
A	HIS292-TYR303

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"18757755","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18757755","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18757755","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19919087","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20121115","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21483814","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22985069","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23025719","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2HD1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YY2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DYN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3JSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3JSW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3K3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3K3H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N3Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4E90","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4G2J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4G2L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GH6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q8QZV1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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