3DT8

Crystal Structure of Bovin Brain Platelet Activating Factor Acetylhydrolase Covalently Inhibited by Sarin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003847	molecular_function	1-alkyl-2-acetylglycerophosphocholine esterase activity
A	0005737	cellular_component	cytoplasm
A	0006629	biological_process	lipid metabolic process
A	0007283	biological_process	spermatogenesis
A	0008247	cellular_component	1-alkyl-2-acetylglycerophosphocholine esterase complex
A	0016042	biological_process	lipid catabolic process
A	0016787	molecular_function	hydrolase activity
A	0042803	molecular_function	protein homodimerization activity
A	0046982	molecular_function	protein heterodimerization activity
A	0047179	molecular_function	platelet-activating factor acetyltransferase activity
A	0052689	molecular_function	carboxylic ester hydrolase activity
A	1902494	cellular_component	catalytic complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Active site: {"evidences":[{"source":"PubMed","id":"8985254","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BWP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1bwp

Chain	Residue	Details
A	ASP192
A	ASN104
A	HIS195
A	GLY74

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site_id	MCSA1
Number of Residues	5
Details	M-CSA 94

Chain	Residue	Details
A	SGB47	covalently attached, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor
A	GLN78	electrostatic stabiliser, hydrogen bond donor
A	HIS108	electrostatic stabiliser, hydrogen bond donor
A	LEU196	activator, electrostatic stabiliser, hydrogen bond acceptor
A	LEU199	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor

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