3DRW

Crystal Structure of a Phosphofructokinase from Pyrococcus horikoshii OT3 with AMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0005737	cellular_component	cytoplasm
A	0005975	biological_process	carbohydrate metabolic process
A	0006000	biological_process	fructose metabolic process
A	0006006	biological_process	glucose metabolic process
A	0006096	biological_process	glycolytic process
A	0008443	molecular_function	phosphofructokinase activity
A	0016301	molecular_function	kinase activity
A	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
A	0043843	molecular_function	ADP-specific glucokinase activity
A	0043844	molecular_function	ADP-specific phosphofructokinase activity
A	0046835	biological_process	carbohydrate phosphorylation
A	0046872	molecular_function	metal ion binding
B	0000287	molecular_function	magnesium ion binding
B	0005737	cellular_component	cytoplasm
B	0005975	biological_process	carbohydrate metabolic process
B	0006000	biological_process	fructose metabolic process
B	0006006	biological_process	glucose metabolic process
B	0006096	biological_process	glycolytic process
B	0008443	molecular_function	phosphofructokinase activity
B	0016301	molecular_function	kinase activity
B	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
B	0043843	molecular_function	ADP-specific glucokinase activity
B	0043844	molecular_function	ADP-specific phosphofructokinase activity
B	0046835	biological_process	carbohydrate phosphorylation
B	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE AMP A 1484

Chain	Residue
A	THR336
A	HOH1656
A	HOH1730
A	THR337
A	ARG420
A	LEU421
A	VAL422
A	LEU431
A	ILE435
A	NA1486
A	HOH1641

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA A 1485

Chain	Residue
A	THR104
A	ARG369
A	ILE375

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA A 1486

Chain	Residue
A	LEU431
A	GLY432
A	AMP1484

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site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE AMP B 1485

Chain	Residue
B	HIS335
B	THR336
B	THR337
B	THR419
B	ARG420
B	LEU421
B	VAL422
B	LEU431
B	GLY432
B	ILE435
B	HOH1707
B	HOH1785

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00561

Chain	Residue	Details
A	ASP433
B	ASP433

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site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00561

Chain	Residue	Details
A	GLU260
A	GLU290
A	ASP433
B	GLU260
B	GLU290
B	ASP433

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