3DP8
Structural characterization of a putative endogenous metal chelator in the periplasmic nickel transporter NikA (nickel butane-1,2,4-tricarboxylate form)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0015675 | biological_process | nickel cation transport |
| A | 0015833 | biological_process | peptide transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016151 | molecular_function | nickel cation binding |
| A | 0020037 | molecular_function | heme binding |
| A | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0043190 | cellular_component | ATP-binding cassette (ABC) transporter complex |
| A | 0046914 | molecular_function | transition metal ion binding |
| A | 0050919 | biological_process | negative chemotaxis |
| A | 0051540 | molecular_function | metal cluster binding |
| A | 0055052 | cellular_component | ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0098716 | biological_process | nickel cation import across plasma membrane |
| A | 1904680 | molecular_function | peptide transmembrane transporter activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0015675 | biological_process | nickel cation transport |
| B | 0015833 | biological_process | peptide transport |
| B | 0016020 | cellular_component | membrane |
| B | 0016151 | molecular_function | nickel cation binding |
| B | 0020037 | molecular_function | heme binding |
| B | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| B | 0042597 | cellular_component | periplasmic space |
| B | 0043190 | cellular_component | ATP-binding cassette (ABC) transporter complex |
| B | 0046914 | molecular_function | transition metal ion binding |
| B | 0050919 | biological_process | negative chemotaxis |
| B | 0051540 | molecular_function | metal cluster binding |
| B | 0055052 | cellular_component | ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0098716 | biological_process | nickel cation import across plasma membrane |
| B | 1904680 | molecular_function | peptide transmembrane transporter activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0015675 | biological_process | nickel cation transport |
| C | 0015833 | biological_process | peptide transport |
| C | 0016020 | cellular_component | membrane |
| C | 0016151 | molecular_function | nickel cation binding |
| C | 0020037 | molecular_function | heme binding |
| C | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| C | 0042597 | cellular_component | periplasmic space |
| C | 0043190 | cellular_component | ATP-binding cassette (ABC) transporter complex |
| C | 0046914 | molecular_function | transition metal ion binding |
| C | 0050919 | biological_process | negative chemotaxis |
| C | 0051540 | molecular_function | metal cluster binding |
| C | 0055052 | cellular_component | ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing |
| C | 0055085 | biological_process | transmembrane transport |
| C | 0098716 | biological_process | nickel cation import across plasma membrane |
| C | 1904680 | molecular_function | peptide transmembrane transporter activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE NI B 503 |
| Chain | Residue |
| B | HIS416 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE NI C 503 |
| Chain | Residue |
| C | HIS416 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT C 504 |
| Chain | Residue |
| C | THR292 |
| C | LEU293 |
| C | LEU455 |
| C | HIS459 |
| C | TYR464 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT C 505 |
| Chain | Residue |
| C | ILE332 |
| C | ARG365 |
| C | LYS330 |
| C | ASP331 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT A 505 |
| Chain | Residue |
| A | SER57 |
| A | GLU58 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT B 504 |
| Chain | Residue |
| B | GLU221 |
| B | LEU226 |
| B | PHE229 |
| B | LEU283 |
| B | THR286 |
| B | MET473 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT C 506 |
| Chain | Residue |
| C | GLN385 |
| C | HIS395 |
| C | ARG396 |
| C | TRP398 |
| C | HIS416 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT A 506 |
| Chain | Residue |
| A | GLN288 |
| B | THR286 |
| B | GLN288 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT B 505 |
| Chain | Residue |
| B | ARG341 |
| C | LYS433 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT B 506 |
| Chain | Residue |
| B | TYR271 |
| B | LYS306 |
| B | PRO307 |
| B | HIS459 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT B 507 |
| Chain | Residue |
| B | THR8 |
| B | ALA9 |
| B | LEU216 |
| B | LEU217 |
| B | TYR218 |
| B | LEU223 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT A 507 |
| Chain | Residue |
| A | ASP93 |
| A | ASN94 |
| A | ARG95 |
| A | GLN96 |
| C | GLN446 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 508 |
| Chain | Residue |
| A | GLN361 |
| A | SER372 |
| A | LEU373 |
| site_id | BC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 508 |
| Chain | Residue |
| B | THR441 |
| B | HIS442 |
| site_id | BC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 509 |
| Chain | Residue |
| B | LEU293 |
| B | HIS459 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE HCT B 511 |
| Chain | Residue |
| B | TYR22 |
| B | ARG97 |
| B | ARG137 |
| B | TRP398 |
| B | HIS416 |
| site_id | BC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE HCT A 511 |
| Chain | Residue |
| A | TYR22 |
| A | ARG97 |
| A | TRP100 |
| A | ARG137 |
| A | TRP398 |
| A | HIS416 |
| site_id | BC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE HCT C 509 |
| Chain | Residue |
| C | TYR22 |
| C | MET27 |
| C | ARG97 |
| C | TRP100 |
| C | ARG137 |
| C | ARG396 |
| C | TRP398 |
| C | HIS416 |
| site_id | CC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 512 |
| Chain | Residue |
| A | ASN274 |
| A | LYS276 |
| A | ASP280 |
| A | LYS316 |
| A | GLU320 |
| A | LEU326 |
| A | ARG333 |
| site_id | CC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 512 |
| Chain | Residue |
| B | PRO48 |
| B | LYS52 |
| B | SER53 |
| B | TRP54 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 513 |
| Chain | Residue |
| A | THR349 |
| A | GLU376 |
| A | GLU377 |
| A | GLU378 |
| site_id | CC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 513 |
| Chain | Residue |
| B | ASN254 |
| B | ALA256 |
| B | LYS257 |
| B | ASP387 |
| B | GLY388 |
| B | GLN420 |
| B | GLN423 |
| site_id | CC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL B 514 |
| Chain | Residue |
| B | SER57 |
| B | GLU58 |
| site_id | CC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 514 |
| Chain | Residue |
| B | PRO487 |
| A | ALA42 |
| A | ASP43 |
| B | GLN41 |
| B | ALA42 |
| B | TYR485 |
| site_id | CC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL A 515 |
| Chain | Residue |
| B | LYS354 |
| B | GLU358 |
| site_id | CC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 515 |
| Chain | Residue |
| A | ARG389 |
| B | GLU358 |
| B | GLN361 |
| B | SER372 |
| B | LEU373 |
Functional Information from PROSITE/UniProt
| site_id | PS01040 |
| Number of Residues | 23 |
| Details | SBP_BACTERIAL_5 Bacterial extracellular solute-binding proteins, family 5 signature. AkswthseDgkTWtFtLRDDVKF |
| Chain | Residue | Details |
| A | ALA51-PHE73 |
