3DP6

Crystal structure of the binding domain of the AMPA subunit GluR2 bound to glutamate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN A 301

Chain	Residue
A	HIS23
A	HOH465
B	ASP65

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 302

Chain	Residue
A	GLU42
A	LYS45
A	HIS46
C	GLU166

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 301

Chain	Residue
C	HIS23
C	ZN301
B	HIS23
B	GLU24

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN B 302

Chain	Residue
B	GLU42
B	LYS45
B	HIS46

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 301

Chain	Residue
B	HIS23
B	GLU24
B	ZN301
C	HIS23

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN C 302

Chain	Residue
A	GLU166
C	GLU42
C	HIS46
C	LEU241
C	HOH375

---

site_id	AC7
Number of Residues	14
Details	BINDING SITE FOR RESIDUE GLU A 374

Chain	Residue
A	TYR61
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	LEU138
A	GLY141
A	SER142
A	THR143
A	GLU193
A	TYR220
A	HOH376
A	HOH401
A	HOH403

---

site_id	AC8
Number of Residues	14
Details	BINDING SITE FOR RESIDUE GLU B 374

Chain	Residue
B	TYR61
B	PRO89
B	LEU90
B	THR91
B	ARG96
B	LEU138
B	GLY141
B	SER142
B	THR143
B	GLU193
B	TYR220
B	HOH376
B	HOH392
B	HOH401

---

site_id	AC9
Number of Residues	14
Details	BINDING SITE FOR RESIDUE GLU C 374

Chain	Residue
C	TYR61
C	PRO89
C	LEU90
C	THR91
C	ARG96
C	LEU138
C	GLY141
C	SER142
C	THR143
C	GLU193
C	TYR220
C	HOH377
C	HOH381
C	HOH392

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
A	PRO89
B	SER142
B	THR143
B	GLU193
C	PRO89
C	THR91
C	ARG96
C	SER142
C	THR143
C	GLU193
A	THR91
A	ARG96
A	SER142
A	THR143
A	GLU193
B	PRO89
B	THR91
B	ARG96

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ARG64
A	ARG148
A	LYS240
B	ARG64
B	ARG148
B	LYS240
C	ARG64
C	ARG148
C	LYS240

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ILE121
B	ILE121
C	ILE121

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER150
B	SER150
C	SER150

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER184
B	SER184
C	SER184

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN3
B	ASN3
C	ASN3

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