Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3DLS

Crystal structure of human PAS kinase bound to ADP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
D	0004672	molecular_function	protein kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation
E	0004672	molecular_function	protein kinase activity
E	0005524	molecular_function	ATP binding
E	0006468	biological_process	protein phosphorylation
F	0004672	molecular_function	protein kinase activity
F	0005524	molecular_function	ATP binding
F	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG A 7

Chain	Residue
A	ASN1133
A	ASP1146

site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG A 8

Chain	Residue
A	ASP1146

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG B 9

Chain	Residue
B	ASN1133
B	ASP1146

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG B 10

Chain	Residue
B	ASP1146

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG C 11

Chain	Residue
C	ASN1133
C	ASP1146

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG C 12

Chain	Residue
C	ASP1146

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG D 13

Chain	Residue
D	ASN1133
D	ASP1146

site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG D 14

Chain	Residue
D	ASP1146

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG E 15

Chain	Residue
E	ASN1133
E	ASP1146

site_id	BC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG E 16

Chain	Residue
E	ASP1146

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG F 17

Chain	Residue
F	ASN1133
F	ASP1146

site_id	BC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG F 18

Chain	Residue
F	ASP1146

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG B 19

Chain	Residue
B	PRO1098
B	GLU1199

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG A 20

Chain	Residue
A	PRO1098
A	GLU1199

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG C 21

Chain	Residue
C	PRO1098
C	GLU1199

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG C 22

Chain	Residue
B	GLY1006
B	GLY1008
B	ALA1009
C	GLU1207

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG D 23

Chain	Residue
D	GLY1006
D	GLY1008
F	GLU1207

site_id	BC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG B 24

Chain	Residue
A	GLY1006
B	GLU1207

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 25

Chain	Residue
A	GLU1207
C	GLY1006
C	GLY1008

site_id	CC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ADP A 1

Chain	Residue
A	LEU1005
A	GLY1006
A	LYS1028
A	ILE1065
A	GLU1082
A	HIS1084
A	GLY1087
A	ASP1089
A	GLU1132
A	ASN1133
A	ILE1145
A	ASP1146

site_id	CC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ADP B 2

Chain	Residue
B	GLY1006
B	LYS1028
B	ILE1065
B	GLU1082
B	HIS1084
B	GLY1087
B	ASP1089
B	GLU1132
B	ASN1133
B	ASP1146

site_id	CC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ADP C 3

Chain	Residue
C	LEU1005
C	GLY1006
C	LYS1028
C	ILE1065
C	MET1081
C	GLU1082
C	HIS1084
C	GLY1087
C	ASP1089
C	GLU1132
C	ASN1133
C	ILE1145
C	ASP1146

site_id	CC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ADP D 4

Chain	Residue
D	LYS1028
D	ILE1065
D	GLU1082
D	HIS1084
D	GLY1087
D	ASP1089
D	GLU1132
D	ASN1133
D	ILE1145
D	ASP1146

site_id	CC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ADP E 5

Chain	Residue
E	LEU1005
E	GLY1006
E	LYS1028
E	ILE1065
E	GLU1082
E	HIS1084
E	GLY1087
E	ASP1089
E	GLU1132
E	ASN1133
E	ILE1145
E	ASP1146

site_id	CC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ADP F 6

Chain	Residue
F	ASP1089
F	GLU1132
F	ASN1133
F	ILE1145
F	ASP1146
F	GLY1006
F	LYS1028
F	ILE1065
F	GLU1082
F	HIS1084
F	GLY1087

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	28
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGAFGFVWtAvdkeknkevvvk......FIKK

Chain	Residue	Details
A	LEU1005-LYS1032

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDIKdeNIVI

Chain	Residue	Details
A	ILE1124-ILE1136

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	252
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	6
Details	Active site: {"description":"Proton acceptor"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	102
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	12
Details	Modified residue: {"description":"Phosphothreonine; by autocatalysis","evidences":[{"source":"PubMed","id":"11459942","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	GLU1132
A	ASP1128

site_id	CSA10
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	LYS1130
D	ASP1128

site_id	CSA11
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
E	LYS1130
E	ASP1128

site_id	CSA12
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
F	LYS1130
F	ASP1128

site_id	CSA13
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	THR1165
A	LYS1130
A	ASP1128

site_id	CSA14
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	THR1165
B	LYS1130
B	ASP1128

site_id	CSA15
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	THR1165
C	LYS1130
C	ASP1128

site_id	CSA16
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	THR1165
D	LYS1130
D	ASP1128

site_id	CSA17
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
E	THR1165
E	LYS1130
E	ASP1128

site_id	CSA18
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
F	THR1165
F	LYS1130
F	ASP1128

site_id	CSA19
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASN1133
A	LYS1130
A	ASP1128

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	GLU1132
B	ASP1128

site_id	CSA20
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASN1133
B	LYS1130
B	ASP1128

site_id	CSA21
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ASN1133
C	LYS1130
C	ASP1128

site_id	CSA22
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	ASN1133
D	LYS1130
D	ASP1128

site_id	CSA23
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
E	ASN1133
E	LYS1130
E	ASP1128

site_id	CSA24
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
F	ASN1133
F	LYS1130
F	ASP1128

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	GLU1132
C	ASP1128

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	GLU1132
D	ASP1128

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
E	GLU1132
E	ASP1128

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
F	GLU1132
F	ASP1128

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	LYS1130
A	ASP1128

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	LYS1130
B	ASP1128

site_id	CSA9
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	LYS1130
C	ASP1128

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)