3DCY
Crystal Structure a TP53-induced glycolysis and apoptosis regulator protein from Homo sapiens.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002931 | biological_process | response to ischemia |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004331 | molecular_function | fructose-2,6-bisphosphate 2-phosphatase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005741 | cellular_component | mitochondrial outer membrane |
| A | 0005829 | cellular_component | cytosol |
| A | 0006914 | biological_process | autophagy |
| A | 0006915 | biological_process | apoptotic process |
| A | 0006950 | biological_process | response to stress |
| A | 0006974 | biological_process | DNA damage response |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0043067 | biological_process | regulation of programmed cell death |
| A | 0043069 | biological_process | negative regulation of programmed cell death |
| A | 0043456 | biological_process | regulation of pentose-phosphate shunt |
| A | 0045739 | biological_process | positive regulation of DNA repair |
| A | 0045820 | biological_process | negative regulation of glycolytic process |
| A | 0045937 | biological_process | positive regulation of phosphate metabolic process |
| A | 0071279 | biological_process | cellular response to cobalt ion |
| A | 0071456 | biological_process | cellular response to hypoxia |
| A | 1902153 | biological_process | regulation of response to DNA damage checkpoint signaling |
| A | 1903301 | biological_process | positive regulation of hexokinase activity |
| A | 1905857 | biological_process | positive regulation of pentose-phosphate shunt |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 A 271 |
| Chain | Residue |
| A | ARG10 |
| A | HIS11 |
| A | ASN17 |
| A | GLN23 |
| A | ARG61 |
| A | GLU89 |
| A | HIS198 |
| A | GLY199 |
Functional Information from PROSITE/UniProt
| site_id | PS00175 |
| Number of Residues | 10 |
| Details | PG_MUTASE Phosphoglycerate mutase family phosphohistidine signature. VvRHGEtRfN |
| Chain | Residue | Details |
| A | VAL8-ASN17 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Tele-phosphohistidine intermediate","evidences":[{"source":"UniProtKB","id":"Q7ZVE3","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"UniProtKB","id":"Q7ZVE3","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"source":"UniProtKB","id":"Q7ZVE3","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1qhf |
| Chain | Residue | Details |
| A | HIS198 | |
| A | HIS11 | |
| A | GLU89 |
