3DCY

Crystal Structure a TP53-induced glycolysis and apoptosis regulator protein from Homo sapiens.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000423	biological_process	mitophagy
A	0002931	biological_process	response to ischemia
A	0003824	molecular_function	catalytic activity
A	0004331	molecular_function	fructose-2,6-bisphosphate 2-phosphatase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005741	cellular_component	mitochondrial outer membrane
A	0005829	cellular_component	cytosol
A	0006003	biological_process	fructose 2,6-bisphosphate metabolic process
A	0006096	biological_process	glycolytic process
A	0006914	biological_process	autophagy
A	0006915	biological_process	apoptotic process
A	0006974	biological_process	DNA damage response
A	0009410	biological_process	response to xenobiotic stimulus
A	0010332	biological_process	response to gamma radiation
A	0010659	biological_process	cardiac muscle cell apoptotic process
A	0010666	biological_process	positive regulation of cardiac muscle cell apoptotic process
A	0016787	molecular_function	hydrolase activity
A	0019661	biological_process	glucose catabolic process to lactate via pyruvate
A	0043069	biological_process	negative regulation of programmed cell death
A	0043456	biological_process	regulation of pentose-phosphate shunt
A	0045739	biological_process	positive regulation of DNA repair
A	0045820	biological_process	negative regulation of glycolytic process
A	0060576	biological_process	intestinal epithelial cell development
A	0071279	biological_process	cellular response to cobalt ion
A	0071456	biological_process	cellular response to hypoxia
A	0072593	biological_process	reactive oxygen species metabolic process
A	1901525	biological_process	negative regulation of mitophagy
A	1902153	biological_process	regulation of response to DNA damage checkpoint signaling
A	1903301	biological_process	positive regulation of hexokinase activity
A	1904024	biological_process	negative regulation of glucose catabolic process to lactate via pyruvate
A	1905857	biological_process	positive regulation of pentose-phosphate shunt
A	2000378	biological_process	negative regulation of reactive oxygen species metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 A 271

Chain	Residue
A	ARG10
A	HIS11
A	ASN17
A	GLN23
A	ARG61
A	GLU89
A	HIS198
A	GLY199

---

Functional Information from PROSITE/UniProt

site_id	PS00175
Number of Residues	10
Details	PG_MUTASE Phosphoglycerate mutase family phosphohistidine signature. VvRHGEtRfN

Chain	Residue	Details
A	VAL8-ASN17

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Tele-phosphohistidine intermediate => ECO:0000250|UniProtKB:Q7ZVE3

Chain	Residue	Details
A	HIS11

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000250|UniProtKB:Q7ZVE3

Chain	Residue	Details
A	GLU89

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Transition state stabilizer => ECO:0000250|UniProtKB:Q7ZVE3

Chain	Residue	Details
A	HIS198

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS50

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1qhf

Chain	Residue	Details
A	HIS198
A	HIS11
A	GLU89

---