3DCY

Crystal Structure a TP53-induced glycolysis and apoptosis regulator protein from Homo sapiens.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000423	biological_process	mitophagy
A	0002931	biological_process	response to ischemia
A	0003824	molecular_function	catalytic activity
A	0004331	molecular_function	fructose-2,6-bisphosphate 2-phosphatase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005741	cellular_component	mitochondrial outer membrane
A	0005829	cellular_component	cytosol
A	0006003	biological_process	fructose 2,6-bisphosphate metabolic process
A	0006096	biological_process	glycolytic process
A	0006914	biological_process	autophagy
A	0006915	biological_process	apoptotic process
A	0006950	biological_process	response to stress
A	0006974	biological_process	DNA damage response
A	0009410	biological_process	response to xenobiotic stimulus
A	0010332	biological_process	response to gamma radiation
A	0010659	biological_process	cardiac muscle cell apoptotic process
A	0010666	biological_process	positive regulation of cardiac muscle cell apoptotic process
A	0016787	molecular_function	hydrolase activity
A	0019661	biological_process	glucose catabolic process to lactate via pyruvate
A	0043067	biological_process	regulation of programmed cell death
A	0043069	biological_process	negative regulation of programmed cell death
A	0043456	biological_process	regulation of pentose-phosphate shunt
A	0045739	biological_process	positive regulation of DNA repair
A	0045820	biological_process	negative regulation of glycolytic process
A	0045935	biological_process	positive regulation of nucleobase-containing compound metabolic process
A	0045937	biological_process	positive regulation of phosphate metabolic process
A	0060576	biological_process	intestinal epithelial cell development
A	0071279	biological_process	cellular response to cobalt ion
A	0071456	biological_process	cellular response to hypoxia
A	0072593	biological_process	reactive oxygen species metabolic process
A	1901525	biological_process	negative regulation of mitophagy
A	1902153	biological_process	regulation of response to DNA damage checkpoint signaling
A	1903301	biological_process	positive regulation of hexokinase activity
A	1904024	biological_process	negative regulation of glucose catabolic process to lactate via pyruvate
A	1905857	biological_process	positive regulation of pentose-phosphate shunt
A	2000378	biological_process	negative regulation of reactive oxygen species metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 A 271

Chain	Residue
A	ARG10
A	HIS11
A	ASN17
A	GLN23
A	ARG61
A	GLU89
A	HIS198
A	GLY199

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Functional Information from PROSITE/UniProt

site_id	PS00175
Number of Residues	10
Details	PG_MUTASE Phosphoglycerate mutase family phosphohistidine signature. VvRHGEtRfN

Chain	Residue	Details
A	VAL8-ASN17

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Tele-phosphohistidine intermediate","evidences":[{"source":"UniProtKB","id":"Q7ZVE3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"UniProtKB","id":"Q7ZVE3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"UniProtKB","id":"Q7ZVE3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1qhf

Chain	Residue	Details
A	HIS198
A	HIS11
A	GLU89

---