Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008270 | molecular_function | zinc ion binding |
| B | 0004222 | molecular_function | metalloendopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008270 | molecular_function | zinc ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE NH2 D 184 |
| Chain | Residue |
| B | ASN242 |
| D | GLU183 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 428 |
| Chain | Residue |
| A | HIS211 |
| A | HIS215 |
| A | GLU250 |
| C | ARG180 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 891 |
| Chain | Residue |
| A | ARG401 |
| A | PHE357 |
| A | PRO397 |
| A | ILE398 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 892 |
| Chain | Residue |
| A | ARG192 |
| A | LYS355 |
| A | HOH971 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 893 |
| Chain | Residue |
| A | ARG393 |
| A | HOH960 |
| A | HOH1001 |
| B | ASP311 |
| B | ALA312 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 894 |
| Chain | Residue |
| A | HIS124 |
| A | GLY126 |
| A | ASP127 |
| A | ARG167 |
| A | HOH943 |
| A | HOH967 |
| A | HOH998 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 896 |
| Chain | Residue |
| A | ASN163 |
| A | MET171 |
| A | LYS224 |
| A | HOH921 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 897 |
| Chain | Residue |
| A | ASP195 |
| A | ASN196 |
| A | SER197 |
| A | HOH911 |
| B | ASN364 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 822 |
| Chain | Residue |
| B | HIS211 |
| B | HIS215 |
| B | GLU250 |
| D | ARG180 |
| site_id | BC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 B 890 |
| Chain | Residue |
| A | SER59 |
| B | HIS124 |
| B | GLY126 |
| B | ASP127 |
| B | LEU166 |
| B | ARG167 |
| B | HOH927 |
| B | HOH981 |
| B | HOH992 |
| B | HOH994 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 895 |
| Chain | Residue |
| B | SER162 |
| B | ASN163 |
| B | MET171 |
| B | LYS224 |
| site_id | BC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR CHAIN C OF SNAP-25 SUBSTRATE PEPTIDE |
| Chain | Residue |
| A | THR159 |
| A | PHE191 |
| A | THR208 |
| A | HIS211 |
| A | GLU212 |
| A | GLU250 |
| A | GLU335 |
| A | ARG347 |
| A | TYR350 |
| A | TYR354 |
| A | TYR356 |
| A | ZN428 |
| site_id | BC4 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR CHAIN D OF SNAP-25 SUBSTRATE PEPTIDE |
| Chain | Residue |
| B | GLU158 |
| B | THR159 |
| B | ASN160 |
| B | SER161 |
| B | PHE191 |
| B | THR208 |
| B | HIS211 |
| B | GLU212 |
| B | ILE240 |
| B | THR241 |
| B | ASN242 |
| B | THR246 |
| B | GLU250 |
| B | GLU335 |
| B | ARG347 |
| B | TYR350 |
| B | ILE351 |
| B | GLY352 |
| B | GLN353 |
| B | TYR354 |
| B | TYR356 |
| B | ZN822 |
| B | HOH901 |
| D | NH2184 |
| D | HOH230 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TLMHELIHSL |
| Chain | Residue | Details |
| A | THR208-LEU217 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1i1e |
| Chain | Residue | Details |
| A | TYR350 | |
| A | ARG347 | |
| A | GLU250 | |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1i1e |
| Chain | Residue | Details |
| B | TYR350 | |
| B | ARG347 | |
| B | GLU250 | |
